期刊
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
卷 149, 期 2, 页码 599-+出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.jaci.2021.07.037
关键词
Chronic rhinosinusitis; nasal polyp; mucosal-associated invariant T cells; MAIT cells; IL-17A; MAIT cells
资金
- National Research Foundation, Republic of Korea [NRF-2018M3A9D3079498]
- Ministry of Science and ICT (MSIT)
- National Research Foundation of Korea [2018M3A9D3079498] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Sinonasal MAIT cells exhibit an activated phenotype and produce higher levels of IL-17A in patients with CRSwNP. These alterations are associated with the extent of disease in patients with E-NP.
Background: Diverse immune cells contribute to the pathogenesis of chronic rhinosinusitis (CRS), an inflammatory disease of the nasal cavity and paranasal sinuses. However, whether mucosal-associated invariant T (MALT) cells are present in human sinonasal tissues remains unclear. Furthermore, the characteristics of sinonasal MALT cells have not been studied in patients with CRS. Objective: We investigated the phenotype, function, and clinical implications of MAIT cells in patients with CRS. Methods: Peripheral blood and sinonasal tissue were obtained from patients with CRS with (CRSwNP) or without nasal polyps (CRSsNP) and healthy controls. MAIT cells were analyzed by flow cytometry. Results: We found that MAIT cells are present in human sinonasal tissues from healthy controls and patients with CRS. The sinonasal MAIT cell population, but not peripheral blood MAIT cells, from patients with CRSsNP, noneosinophilic CRSwNP (NE-NP), or eosinophilic CRSwNP (E-NP) had a significantly higher frequency of activated cells marked by CD38 expression. In functional analysis, the sinonasal MAIT cell population from NE-NP and E-NP had a significantly higher frequency of IL-17A(+) cells but lower frequency of IFN-gamma(+) or TNF+ cells than control sinonasal tissues. Furthermore, CD38 expression and IL-17A production by sinonasal MAIT cells significantly correlated with disease extent evaluated by the Lund-Mackay computed tomography score in patients with E-NP. Conclusions: Sinonasal MAIT cells exhibit an activated phenotype and produce higher levels of IL-17A in patients with CRSwNP. These alterations are associated with the extent of disease in patients with E-NP.
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