4.7 Review

JAK inhibitors in the treatment of atopic dermatitis

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Article Dermatology

Pooled safety analysis of baricitinib in adult patients with atopic dermatitis from 8 randomized clinical trials

T. Bieber et al.

Summary: This study reports pooled safety data for baricitinib in patients with moderate-to-severe AD, confirming the established safety profile of baricitinib in this population.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2021)

Article Allergy

The molecular features of normal and atopic dermatitis skin in infants, children, adolescents, and adults

Yael Renert-Yuval et al.

Summary: The common signature of AD across ages is T(H)2/T(H)22-skewed, but the specific expression of cytokines varies widely. Barrier abnormalities are present in all AD age groups, but significant decreases in filaggrin expression are only seen in adults.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

Article Dermatology

Baricitinib in patients with moderate-tosevere atopic dermatitis: Results from a randomized monotherapy phase 3 trial in the United States and Canada (BREEZE-AD5)

Eric L. Simpson et al.

Summary: The study evaluated the efficacy and safety of baricitinib monotherapy in patients with moderate-to-severe AD who responded inadequately or were intolerant to topical therapy. Results showed a higher proportion of patients achieving efficacy endpoints in the baricitinib groups at week 16.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2021)

Article Dermatology

Extended Safety Analysis of Baricitinib 2 mg in Adult Patients with Atopic Dermatitis: An Integrated Analysis from Eight Randomized Clinical Trials

Brett King et al.

Summary: This study evaluated the safety of baricitinib 2 mg in treating moderate-to-severe AD, and found that treatment-emergent adverse events were higher with the drug compared to placebo, but serious adverse events were low and similar between the two groups. The integrated analysis confirmed the established safety profile of baricitinib 2 mg in patients with AD, but longer exposure to treatment is needed to assess the risks of malignancies and major adverse cardiovascular events.

AMERICAN JOURNAL OF CLINICAL DERMATOLOGY (2021)

Article Dermatology

Patient-Reported Symptoms and Disease Impacts in Adults With Moderate-to-Severe Atopic Dermatitis: Results From a Phase 2b Study With Abrocitinib

Eric L. Simpson et al.

Summary: Abrocitinib treatment resulted in rapid and persistent improvements in symptoms and impacts of atopic dermatitis in moderate-to-severe disease patients.

DERMATITIS (2021)

Article Dermatology

Impact of baricitinib in combination with topical steroids on atopic dermatitis symptoms, quality of life and functioning in adult patients with moderate-to-severe atopic dermatitis from the BREEZE-AD7 Phase 3 randomized trial

A. Wollenberg et al.

Summary: Baricitinib plus TCS showed significant improvements in HRQoL, work productivity, and life functioning in patients with moderate-to-severe AD, indicating its potential as an effective treatment option.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2021)

Article Medicine, General & Internal

Abrocitinib versus Placebo or Dupilumab for Atopic Dermatitis

Thomas Bieber et al.

Summary: The study demonstrated that both 200 mg and 100 mg doses of abrocitinib showed significant efficacy in treating moderate-to-severe atopic dermatitis compared to placebo, with the 200 mg dose being superior to dupilumab in improving itch response. Neither dose of abrocitinib showed significant differences from dupilumab in most other key secondary endpoints at week 16.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Dermatology

Long-term Efficacy of Baricitinib in Adults With Moderate to Severe Atopic Dermatitis Who Were Treatment Responders or Partial Responders An Extension Study of 2 Randomized Clinical Trials

Jonathan I. Silverberg et al.

Summary: Baricitinib, a selective Janus kinase inhibitor, showed sustained long-term efficacy for patients with moderate to severe atopic dermatitis through 52 weeks of continuous therapy, improving clinical assessment scores and itch symptoms.

JAMA DERMATOLOGY (2021)

Article Dermatology

25977 Selected infection topics in adult patients with moderate-to-severe atopic dermatitis treated with baricitinib

Melinda Gooderham et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2021)

Article Medicine, General & Internal

Once-daily upadacitinib versus placebo in adolescents and adults with moderate-to-severe atopic dermatitis (Measure Up 1 and Measure Up 2): results from two replicate double- blind, randomised controlled phase 3 trials

Emma Guttman-Yassky et al.

Summary: The clinical trials demonstrated that Upadacitinib may be an effective treatment option for moderate-to-severe atopic dermatitis, with a significant improvement in symptoms for most patients within 16 weeks, and both dosages were well tolerated.

LANCET (2021)

Article Allergy

Treatment of atopic dermatitis with ruxolitinib cream (JAKI/JAK2 inhibitor) or triamcinolone cream

Brian S. Kim et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)

Article Allergy

Evolution of pathologic T-cell subsets in patients with atopic dermatitis from infancy to adulthood

Tali Czarnowicki et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)

Article Dermatology

No evidence of increased cancer incidence in children using topical tacrolimus for atopic dermatitis

Amy S. Paller et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2020)

Article Medicine, General & Internal

Atopic dermatitis: Tofacitinib, an option for refractory disease

Sineida Berbert Ferreira et al.

CLINICAL CASE REPORTS (2020)

Review Allergy

Comorbidities and the impact of atopic dermatitis

Jonathan I. Silverberg

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY (2019)

Article Allergy

Pain Is a Common and Burdensome Symptom of Atopic Dermatitis in United States Adults

Jonathan I. Silverberg et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2019)

Article Allergy

Phase 2 clinical study of delgocitinib ointment in pediatric patients with atopic dermatitis

Hidemi Nakagawa et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2019)

Review Allergy

Atopic dermatitis endotypes and implications for targeted therapeutics

Tali Czarnowicki et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2019)

Letter Dermatology

A retrospective study: Application site pain with the use of crisaborole, a topical phosphodiesterase 4 inhibitor

Christine Pao-Ling Lin et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2019)

Article Allergy

Health Utility Scores of Atopic Dermatitis in US Adults

Jonathan Silverberg et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2019)

Article Allergy

Atopic dermatitis yardstick: Practical recommendations for an evolving therapeutic landscape

Mark Boguniewicz et al.

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY (2018)

Letter Allergy

Atopic dermatitis in US adults Epidemiology, association with marital status, and atopy

Tammy Hua et al.

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY (2018)

Article Allergy

Patient burden and quality of life in atopic dermatitis in US adults GI A population-based cross-sectional study

Jonathan I. Silverberg et al.

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY (2018)

Article Allergy

Association of atopic dermatitis with allergic, autoimmune, and cardiovascular comorbidities in US adults

Jonathan I. Silverberg et al.

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY (2018)

Review Allergy

Itch: From mechanism to (novel) therapeutic approaches

Gil Yosipovitch et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2018)

Review Allergy

The immunology of atopic dermatitis and its reversibility with broad-spectrum and targeted therapies

Patrick M. Brunner et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2017)

Review Dermatology

JAK inhibitors in dermatology: The promise of a new drug class

William Damsky et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2017)

Review Rheumatology

Type I/II cytokines, JAKs, and new strategies for treating autoimmune diseases

Daniella M. Schwartz et al.

NATURE REVIEWS RHEUMATOLOGY (2016)

Article Dermatology

Topical tofacitinib for atopic dermatitis: a phase IIa randomized trial

R. Bissonnette et al.

BRITISH JOURNAL OF DERMATOLOGY (2016)

Article Dermatology

Burden of Sleep and Fatigue in US Adults With Atopic Dermatitis

Sherry H. Yu et al.

DERMATITIS (2016)

Article Medicine, General & Internal

Two Phase 3 Trials of Dupilumab versus Placebo in Atopic Dermatitis

E. L. Simpson et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Review Allergy

Genetic and epigenetic studies of atopic dermatitis

Lianghua Bin et al.

ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY (2016)

Review Medicine, Research & Experimental

The JAK-STAT Pathway: Impact on Human Disease and Therapeutic Intervention

John J. O'Shea et al.

ANNUAL REVIEW OF MEDICINE, VOL 66 (2015)

Article Dermatology

Treatment of recalcitrant atopic dermatitis with the oral Janus kinase inhibitor tofacitinib citrate

Lauren L. Levy et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2015)

Article Chemistry, Medicinal

Discovery and Development of Janus Kinase (JAK) Inhibitors for Inflammatory Diseases

James D. Clark et al.

JOURNAL OF MEDICINAL CHEMISTRY (2014)

Article Dermatology

Guidelines of care for the management of atopic dermatitis

Robert Sidbury et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2014)

Article Dermatology

Guidelines of care for the management of atopic dermatitis Section 2. Management and treatment of atopic dermatitis with topical therapies

Lawrence F. Eichenfield et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2014)

Review Allergy

New Insights into Atopic Dermatitis: Role of Skin Barrier and Immune Dysregulation

Donald Y. M. Leung

ALLERGOLOGY INTERNATIONAL (2013)

Article Immunology

Modulation of Innate and Adaptive Immune Responses by Tofacitinib (CP-690,550)

Kamran Ghoreschi et al.

JOURNAL OF IMMUNOLOGY (2011)

Article Medicine, General & Internal

Endogenous antimicrobial peptides and skin infections in atopic dermatitis

PY Ong et al.

NEW ENGLAND JOURNAL OF MEDICINE (2002)