期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 69, 期 28, 页码 7817-7830出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.1c03007
关键词
Alternaria mycotoxins; food; toxicity; metabolic mechanism; analytical method
资金
- National Natural Science Foundation of China [31871718]
- Science and Technology Innovation Development Project in Yantai [2021XDHZ080]
The genus Alternaria, widely distributed in the environment, produces toxic secondary metabolites known as Alternaria mycotoxins. These toxins are ubiquitously present in foodstuffs and exhibit genotoxic and cytotoxic effects. Alternaria toxins mainly undergo hydroxylation to catechol metabolites and are combined with sulfate and glucuronic acid.
The genus Alternaria is widely distributed in the environment. Numerous species of the genus Alternaria can produce a variety of toxic secondary metabolites, called Alternaria mycotoxins. In this review, natural occurrence, toxicity, metabolism, and analytical methods are introduced. The contamination of these toxins in foodstuffs is ubiquitous, and most of these metabolites present genotoxic and cytotoxic effects. Moreover, Alternaria toxins are mainly hydroxylated to catechol metabolites and combined with sulfate and glucuronic acid in in vitro arrays. A more detailed summary of the metabolism of Alternaria toxins is presented in this work. To effectively detect and determine the mycotoxins in food, analytical methods with high sensitivity and good accuracy are also reviewed. This review will guide the formulation of maximum residue limit standards in the future, covering both toxicity and metabolic mechanism of Alternaria toxins.
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