期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 69, 期 25, 页码 7127-7136出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.1c00953
关键词
phthalate; DEHP; colorectal cancer; urinary MEHP; liquid chromatography with tandem mass spectrometry phthalate; noninvasive indicator
资金
- Ministry of Science and Technology, Taiwan [MOST 109-2314-B-037-035, MOST 109-2314-B-037-040, MOST 109-2314-B-037-046-MY3]
- Ministry of Health and Welfare - health and welfare surcharge of tobacco products [MOHW109-TDU-B-212-134026, MOHW109-TDU-B-212-114006, MOHW110-TDU-B-212-1140026]
- Kaohsiung Medical University Hospital [KMUH109-9R32, KMUH109-9R33, KMUH109-9R34, KMUH109-9M30, KMUH109-9M31, KMUH109-9M32, KMUH109-9M33, KMUH108-8M35, KMUH106-6M30, KMUH105-5M21, KMUH104-4M25, KMUHS10903, KMUHSA10903, KMUH-DK(C) 110010, KMUH-DK(B)110004-3]
- Center for Cancer Research [KMU-TC109A04-1]
- Center for Liquid Biopsy and Cohort Research Center Grant [KMU-TC109B05]
- Kaohsiung Medical University
- Grant of Taiwan Precision Medicine Initiative, Academia Sinica, Taiwan, R.O.
Exposure to di-(2-ethylhexyl) phthalate (DEHP) is significantly correlated with the development of colorectal cancer (CRC). Detection of urinary monoethylhexyl phthalate (MEHP) may serve as a noninvasive indicator for increased CRC risk.
Colorectal cancer (CRC) is the third leading cause of cancer death in Taiwan. A recent study suggested a link between exposure to endocrine-disrupting chemicals (EDCs) and increased susceptibility to pathology. Exposure to di-(2-ethylhexyl) phthalate (DEHP), an EDC and plasticizer widely used in consumer products, has been reported to be significantly positively correlated with increased risks of various cancers. We explored this connection of DEHP exposure with the development of CRC through the detection of urinary monoethylhexyl phthalate (MEHP), a potent metabolite of DEHP. Participants comprised 221 individuals recruited between October 2016 and November 2019 from a single institution. Overall, urinary MEHP concentrations were significantly higher in patients with CRC than in the patients with adenoma or healthy participants (both P < 0.001). Higher exposure to DEHP may contribute to the occurrence of CRC. Urinary MEHP detection may serve as a beneficial noninvasive indicator of increased CRC risk.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据