期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 69, 期 33, 页码 9498-9510出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.1c03864
关键词
sesquiterpene; metabolic engineering; synthetic biology; Saccharomyces cerevisiae; Yarrowia lipolytica
资金
- National Key Research and Development Program of China [2021YFC2101500]
- National Natural Science Foundation of China [21922806, 21776131, 22061130203]
- Key Research and Development Program of Jiangsu Province [BE2020782]
- BBSRC [BB/R01602X/1]
- Newton Advanced Fellowship [NAF\R1\201187]
- British Council/Newton Fund Institutional Links [527429894]
- BBSRC [BB/R01602X/1] Funding Source: UKRI
Sesquiterpenes are natural compounds composed of three isoprene units with remarkable biological activities and complex structures, widely used in flavor, pharmaceutical and biofuel industries. The microbial production of sesquiterpenes, driven by metabolic engineering and synthetic biology, offers a promising alternative to plant extraction and chemical synthesis to meet market demand.
Sesquiterpenes are natural compounds composed of three isoprene units. They represent the largest class of terpene compounds found in plants, and many have remarkable biological activities. Furthermore, sesquiterpenes have broad applications in the flavor, pharmaceutical and biofuel industries due to their complex structures. With the development of metabolic engineering and synthetic biology, the production of different sesquiterpenes has been realized in various chassis microbes. The microbial production of sesquiterpenes provides a promising alternative to plant extraction and chemical synthesis, enabling us to meet the increasing market demand. In this review, we summarized the heterologous production of different plant sesquiterpenes using the eukaryotic yeasts Saccharomyces cerevisiae and Yarrowia lipolytica, followed by a discussion of common metabolic engineering strategies used in this field.
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