Role of Polyphenols on Gut Microbiota and the Ubiquitin-Proteasome System in Neurodegenerative Diseases

Today, neurodegenerative diseases have become a remarkable public health challenge due to their direct relation with aging. Accordingly, understanding the molecular and cellular mechanisms occurring in the pathogenesis of them is essential. Both protein aggregations as a result of the ubiquitin-proteasome system (UPS) inefficiency and gut microbiota alternation are the main pathogenic hallmarks. Polyphenols upregulating this system may decrease the developing rate of neurodegenerative diseases. Most of the dietary intake of polyphenols is converted into other microbial metabolites, which have completely different biological properties from the original polyphenols and should be thoroughly investigated. Herein, several prevalent neurodegenerative diseases are pinpointed to explain the role of gut microbiota alternations and the role of molecular changes, especially UPS down-regulation in their pathogenesis. Some of the most important polyphenols found in our diet are explained along with their microbial metabolites in the body.

Automated summary

Neurodegenerative diseases are a significant public health challenge due to their association with aging. Understanding the molecular and cellular mechanisms involved in their pathogenesis is crucial. Protein aggregations resulting from UPS inefficiency and gut microbiota alternations are key pathogenic features, with polyphenols potentially playing a role in decreasing disease development rates. The conversion of dietary polyphenols into different microbial metabolites with diverse biological properties highlights the need for thorough investigation.