Effect and safety evaluation of tacrolimus and tripterygium glycosides combined therapy in treatment of Henoch-Schonlein purpura nephritis

Objective Henoch-Schonlein purpura nephritis has become a significant threat to children's health. Traditional combined therapy of glucocorticoids and cyclophosphamide leads to severe toxicity and complications. Therefore, identifying a feasible and effective strategy with low side-effects for the treatment of Henoch-Schonlein purpura nephritis is of great significance. Methods A randomized, controlled trial was carried out. A total of 279 children with Henoch-Schonlein purpura nephritis were recruited and randomly divided into three groups: control group (receiving the current standard therapy), TA group (receiving tacrolimus) and TA + tripterygium glycosides group (receiving tacrolimus + tripterygium treatment). The total duration of the trial was 6 months, and the duration of follow-up observation was 9 months. Results Various therapies showed similar therapeutic effects in the third and sixth months. The relief of Henoch-Schonlein purpura nephritis symptoms caused by TA + tripterygium glycosides was slower than the TA and control groups. The incidence of adverse reactions in the TA + tripterygium glycosides group was lower in the control and TA groups. The final treatment effect of the experimental groups was better than the control group. The recurrence rate in the TA + tripterygium glycosides group was also significantly lower. Conclusion Tacrolimus and tripterygium glycosides combined therapy had better effects and safety for long-term treatment of Henoch-Schonlein purpura nephritis.

Automated summary

The combination therapy of tacrolimus and tripterygium glycosides shows better therapeutic effects and lower adverse reactions for the long-term treatment of Henoch-Schonlein purpura nephritis.