期刊
INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE
卷 25, 期 7, 页码 537-+出版社
INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D)
DOI: 10.5588/ijtld.21.0034
关键词
tuberculosis; clinical features; CPA; differential diagnosis; differences
资金
- Fogarty International Centre of the National Institutes of Health (NIH) , Bethesda, MD, USA [D43 TW011401]
PTB and CPA have overlapping clinical and radiological manifestations, with Aspergillus-specific IgG serology playing a key role in differentiating between the two diseases.
BACKGROUND: Pulmonary TB (PTB) and chronic pulmonary aspergillosis (CPA) are both progressive and debilitating parenchymal lung diseases with overlapping risk factors, symptomatology and radiological findings that often result in misdiagnosis of either disease. M E T H O D S : We undertook a narrative review approach to describe the clinical and radiological manifestations of CPA and PTB and highlight the salient features that differentiate these two closely related maladies. RES U LT S : CPA is a frequent complication of treated PTB. In fact, 15-90% of CPA cases occur in patients with residual lung lesions following treatment for PTB. While CPA predominantly affects older patients with underlying lung diseases, both PTB and CPA present with clinically indistinguishable symptoms. Chest imag-ing findings of cavitation and fibrosis are common to both diseases. However, lymphadenopathy, miliary pattern and pleural effusion are predictive of active PTB, while aspergilloma, pleural thickening and para-cavitary fibrosis are more common in CPA. Aspergillus- specific IgG serology has a central role in differentiating PTB (both active and healed) from CPA with a high sensitivity and specificity. CON C L U S I O N : Aspergillus-specific IgG serology is key in differentiating PTB and PTB relapse from CPA. It may be worthwhile developing clinical predictive scores that can be used in low-income settings to differentiate active TB, post-TB disease and TB & thorn;CPA co-infection.
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