A bond between rheumatic diseases and cancer in the elderly: The interleukin-6 pathway

Review Chemistry, Medicinal

Osteoarthritis: Prognosis and emerging therapeutic approach for disease management

Amresh Kumar et al.

Summary: This paper discusses the pathogenesis, treatment methods, and the impact of disease prognosis on cellular signaling pathways in osteoarthritis.

DRUG DEVELOPMENT RESEARCH (2021)

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Review Cell Biology

IL-6 as a major regulator of MDSC activity and possible target for cancer immunotherapy

Rebekka Weber et al.

Summary: MDSC are crucial cells generated during tumor progression that suppress the anti-tumor functions of T and NK cells. IL-6 plays a key role in regulating the accumulation and activation of MDSC, as well as stimulating tumor cell proliferation and survival. This cytokine has pleiotropic effects on immune cell populations involved in tumor development and is a potential target for tumor immunotherapy to block MDSC-mediated immunosuppression in cancer patients.

CELLULAR IMMUNOLOGY (2021)

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Review Biochemistry & Molecular Biology

Role of Physical Exercise and Nutraceuticals in Modulating Molecular Pathways of Osteoarthritis

Alessandro de Sire et al.

Summary: Osteoarthritis is a common and painful disease with unknown etiology, likely influenced by multiple factors. Exercise and naturally derived compounds have been suggested to delay OA progression.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Pharmacology & Pharmacy

New Viscoelastic Hydrogel Hymovis MO.RE. Single Intra-articular Injection for the Treatment of Knee Osteoarthritis in Sportsmen: Safety and Efficacy Study Results

Andrea Bernetti et al.

Summary: The study demonstrates that a single intra-articular injection of the new HA derivative hydrogel, Hymovis MO.RE., provides significant efficacy and safety in improving knee function, pain, and quality of life for adult regular sports players with osteoarthritis. No severe adverse events were detected, indicating it may be a viable therapeutic option for this patient subgroup. Further investigations are needed to confirm these findings.

FRONTIERS IN PHARMACOLOGY (2021)

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Review Nutrition & Dietetics