期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 607, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.ijpharm.2021.120840
关键词
Porous silicon; Ibuprofen; Supercritical fluid; Controlled release; Degradable
Supercritical fluid (SCF) assisted drying of porous silicon results in higher mesopore volumes and surface areas, achieving higher drug payloads and improved in-vitro drug release performance.
Porous silicon has found increased attention as a drug delivery system due to its unique features such as high drug payloads, surface area and biodegradation. In this study supercritical fluid (SCF) assisted drying of ultrahigh porosity (>90%) silicon particles and flakes was shown to result in much higher mesopore volumes (-4.66 cm3/ g) and surface areas (-680 m2/g) than with air-drying. The loading and physical state of the model drug (S)(+)-Ibuprofen in SCF dried matrices was quantified and assessed using thermogravimetric analysis, differential scanning calorimetry, UV-Vis spectrophotometry, gravimetric analysis, gas adsorption and electron microscopy. Internal drug payloads of up to 72% were achieved which was substantially higher than values published for both conventionally dried porous silicon (17-51%) and other mesoporous materials (7-45%). In-vitro degradability kinetics of SCF-dried matrices in simulated media was also found to be faster than air-dried controls. The in-vitro release studies provided improved but sustained drug dissolution at both pH 2.0 and pH 7.4.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据