期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 602, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.ijpharm.2021.120584
关键词
Radiation-induced lung injury; Melatonin; Nanoparticles; TGF-beta 1; Smad3; miR-21
资金
- [SKLZZ201903]
- [19QNP006]
- [ALJ19J002]
The study found that MET/PLGANPS had a better therapeutic effect on RILI than MET, alleviating RILI by inhibiting the miR-21/TGF-beta 1/Smad3 pathway.
Radiation-induced lung injury (RILI) is a complication commonly found in victims suffering from nuclear accidents and patients treated with chest tumor radiotherapy, and drugs are limited for effective prevention and treatment. Melatonin (MET) has an anti-radiation effect, but its metabolic period in the body is short. In order to prolong the metabolism period of MET, we prepared MET entrapped poly (lactic-co-glycolic acid) nanoparticles (MET/PLGANPS) for the treatment of RILI. As a result, the release rate of MET/PLGANPS in vitro was lower than MET, with stable physical properties, and it caused no changes in histopathology and biochemical indicators. After 2 weeks and 16 weeks of irradiation with the dose of 15 Gy, MET and MET/PLGANPS could reduce the expression of caspase-3 proteins, inflammatory factors, TGF-beta 1 and Smad3 to alleviate radiation-induced lung injury. MET/PLGANPS showed better therapeutic effect on RILI than MET. In addition, we also found that high expression of miR-21 could increase the expression levels of TGF-beta 1, and inhibit the protective effect of MET/PLGANPS. In conclusion, MET/PLGANPS may alleviate RILI by inhibiting the miR-21/TGF-beta 1/Smad3 pathway, which would provide a new target for the treatment of radiation-induced lung injury.
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