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Drug delivery to the anterior segment of the eye: A review of current and future treatment strategies

期刊

出版社

ELSEVIER
DOI: 10.1016/j.ijpharm.2021.120924

关键词

Ophthalmic drug-delivery; Formulations; Ocular; Cornea-conjunctiva barrier

资金

  1. National Eye Institute [P30-EY026877]
  2. Research to Prevent Blindness
  3. National Institute of Biomedical Imaging and Bioengineering [5T32EB009035]
  4. Stanford University
  5. University of Southern California

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Research in ophthalmic drug formulations has focused on improving drug penetration and bioavailability in the eye, as well as developing technologies to overcome physiological and anatomical barriers. Innovative technologies and formulations have been developed to extend the duration of drug action and enhance therapeutic effects for patients.
Research in the development of ophthalmic drug formulations and innovative technologies over the past few decades has been directed at improving the penetration of medications delivered to the eye. Currently, approximately 90% of all ophthalmic drug formulations (e.g. liposomes, micelles) are applied as eye drops. The major challenge of topical eye drops is low bioavailability, need for frequent instillation due to the short half-life, poor drug solubility, and potential side effects. Recent research has been focused on improving topical drug delivery devices by increasing ocular residence time, overcoming physiological and anatomical barriers, and developing medical devices and drug formulations to increase the duration of action of the active drugs. Researchers have developed innovative technologies and formulations ranging from sub-micron to macroscopic size such as prodrugs, enhancers, mucus-penetrating particles (MPPs), therapeutic contact lenses, and collagen corneal shields. Another approach towards the development of effective topical drug delivery is embedding therapeutic formulations in microdevices designed for sustained release of the active drugs. The goal is to optimize the delivery of ophthalmic medications by achieving high drug concentration with prolonged duration of action that is convenient for patients to administer.

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