期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 606, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.ijpharm.2021.120909
关键词
Large ring cyclodextrin; Domperidone; Inclusion complexes; Isolation
资金
- Chulalongkorn University, The Second Century Fund (C2F)
- Program Management Unit for Human Resources & Institutional Development, Research and Innovation, NXPO [B05F630025]
- Structural and Computational Biology Research Unit
- Ratchadapisek Somphot Fund for Postdoctoral Fellowship, Chulalongkorn University
- Chulalongkorn University Fund (Ratchadaphiseksomphot Endowment Fund)
- Overseas Research Experience Scholarship for Graduate Student from the Graduate School
Complexation of domperidone with large ring cyclodextrins can significantly improve its water solubility, with the LR-CD/DMP complex showing the most significant enhancement. The molecular dynamic results indicate that stable complexes are formed between DMP and CD33, leading to a 2.7-fold increase in DMP solubility.
The water solubility of domperidone (DMP) could be improved by complexation with large ring cyclodextrins (LR-CDs). LR-CDs contain a relatively hydrophobic cavity that is capable of entrapping the molecules to form inclusion complexes. The complex formation capability of mixture LR-CDs having a degree of polymerization (DP) of 22-48, with DMP was investigated. The phase solubility profile of mixture LR-CD/DMP was classified as AN-type, resulting in increased DMP solubility in water by 3-fold. Various physicochemical techniques confirmed the mixture LR-CD/DMP complex formation. Single LR-CD with DP of 26, 27, 28, 29, 30, 33 and 34 (CD26 similar to CD34) were isolated from LR-CD mixtures using ODS column for HPLC separation. The CD33/DMP complex has demonstrated the most significant improvement compared to other single LR-CD complexes with a 2.7-fold increase in DMP solubility. The molecular dynamic result revealed that DMP formed stable complexes with CD33 by positioned fully encapsulated inside the cavity and covered by 13-14 subunits of CD33.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据