期刊
INTERNATIONAL JOURNAL OF NANOMEDICINE
卷 16, 期 -, 页码 6097-6113出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/IJN.S321984
关键词
uperparamagnetic iron oxide nanoparticles; stem cells; cytotoxicity; biological behavior
资金
- Major State Basic Research Development Program of China [2017YFA0104303]
- National Natural Science Foundation of China [81970883, 81970885]
- Six talent peaks project in Jiangsu Province [YY-073]
- Project of Invigorating Health Care through Science, Technology and Education
Superparamagnetic iron oxide nanoparticles (SPIONs) are extensively studied and utilized in biomedicine due to their superb superparamagnetic properties and reliable traceability. However, different SPIONs exhibit variations in cytotoxicity, metabolism, and cellular behaviors. A comprehensive review of the construction and application of SPIONs is necessary to address these differences.
Superparamagnetic iron oxide nanoparticles (SPIONs) have been widely investigated and applied in the field of biomedicine due to their excellent superparamagnetic properties and reliable traceability. However, with the optimization of core composition, shell types and transfection agents, the cytotoxicity and metabolism of different SPIONs have great differences, and the labeled cells also show different cellular behaviors. Therefore, a holistic review of the construction and application of SPIONs is desired. This review focuses the advances of SPIONs in the field of biomedicine in recent years. After summarizing the toxicity of different SPIONs, the uptake, distribution and metabolism of SPIONs in vitro were discussed. Then, the regulation of labeled-cells behavior is outlined. Furthermore, the major challenges in the optimization process of SPIONs and insights on its future developments are proposed.
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