期刊
INTERNATIONAL JOURNAL OF NANOMEDICINE
卷 16, 期 -, 页码 5395-5409出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/IJN.S313912
关键词
tumor-derived extracellular vesicles; immune cell; regulatory effects; drug delivery; immunotherapy
资金
- China Postdoctoral Science Foundation [2020M673491]
- Fundamental Research Funds for the Central Universities [3102020smxy007]
- Training Program of Innovation and Entrepreneurship for Undergraduates [S202010699401]
The article discusses the effects of tumor-derived extracellular vesicles on immune cells and summarizes their research progress in tumor immunotherapy and diagnosis.
Nowadays, tumor has been the serious threat to human health and life. To further explore the mechanism of tumor genesis and development is necessarily for developing the effective treatment strategy. Extracellular vesicles are the vesicles secreted by almost all types of cells, and they play an important part in intercellular communication by transporting their cargoes. Immune cells are the vital components of the human defense system, which defense against infection and tumor through cytotoxicity, immune surveillance, and clearance. However, via release tumor-derived extracellular vesicles, tumor could induce immune cells dysfunction to facilitate its proliferation and metastasis. Studies have shown that tumor-derived extracellular vesicles play dual role on immune cells by their specific cargoes. Here, we reviewed the effects of tumor-derived extracellular vesicles on immune cells in recent years and also summarized their research progress in the tumor immunotherapy and diagnosis.
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