4.7 Article

Formation of Multicolor Nanogels Based on Cationic Polyfluorenes and Poly(methyl vinyl ether-alt-maleic monoethyl ester): Potential Use as pH-Responsive Fluorescent Drug Carriers

期刊

出版社

MDPI
DOI: 10.3390/ijms22179607

关键词

nanogels; PMVEMA; fluorescent conjugated polymers; doxorubicin; nanoparticles; drug-delivery; bioimaging

资金

  1. Spanish Ministry of Economy, Industry, and Competitiveness [MAT-2017-86805-R]
  2. Generalitat Valenciana-Conselleria d'Educacio Investigacio Cultura i Esport
  3. EU-FEDER Una forma de hacer Europa [2018/020]
  4. Ministry of Science and Innovation
  5. EU-FEDER [EQC2019-005842-P]
  6. Generalitat Valenciana, Conselleria d'Educacio, Investigacio, Cultura i Esport [ACIF/2018/226]

向作者/读者索取更多资源

This study developed fluorescent nanoparticles with pH-sensitive properties, capable of holding drugs in acidic media and releasing them at physiological pH. Furthermore, these nanoparticles have potential use as image probes.
In this study, we employed the copolymer poly(methyl vinyl ether-alt-maleic monoethyl ester) (PMVEMA-Es) and three fluorene-based cationic conjugated polyelectrolytes to develop fluorescent nanoparticles with emission in the blue, green and red spectral regions. The size, Zeta Potential, polydispersity, morphology, time-stability and fluorescent properties of these nanoparticles were characterized, as well as the nature of the interaction between both PMVEMA-Es and fluorescent polyelectrolytes. Because PMVEMA-Es contains a carboxylic acid group in its structure, the effects of pH and ionic strength on the nanoparticles were also evaluated, finding that the size is responsive to pH and ionic strength, largely swelling at physiological pH and returning to their initial size at acidic pHs. Thus, the developed fluorescent nanoparticles can be categorized as pH-sensitive fluorescent nanogels, since they possess the properties of both pH-responsive hydrogels and nanoparticulate systems. Doxorubicin (DOX) was used as a model drug to show the capacity of the blue-emitting nanogels to hold drugs in acidic media and release them at physiological pH, from changes in the fluorescence properties of both nanoparticles and DOX. In addition, preliminary studies by super-resolution confocal microscopy were performed, regarding their potential use as image probes.

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