期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 22, 期 18, 页码 -出版社
MDPI
DOI: 10.3390/ijms22189664
关键词
fatty acid; monoglyceride; lipid nanoparticle; liposome; bicelle; solid lipid nanoparticle; nanostructured lipid carrier; nanoemulsion; lipid nanocapsule; polymeric micelle
资金
- International Research & Development Program of the National Research Foundation of Korea (NRF) - Ministry of Science and ICT [2020K1A3A1A39112724]
- Brain Pool Program through the National Research Foundation of Korea (NRF) - Ministry of Science and ICT [2019H1D3A1A01070318]
- National Research Foundation of Korea [2020K1A3A1A39112724, 2019H1D3A1A01070318] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
The utilization of lipid nanoparticles to deliver fatty acids and monoglycerides for treating medical diseases shows promising potential, with a focus on understanding the relationship between nanoparticle structure and biological function. Opportunities for translation and regulatory needs are discussed, highlighting unmet clinical opportunities.
There is enormous interest in utilizing biologically active fatty acids and monoglycerides to treat phospholipid membrane-related medical diseases, especially with the global health importance of membrane-enveloped viruses and bacteria. However, it is difficult to practically deliver lipophilic fatty acids and monoglycerides for therapeutic applications, which has led to the emergence of lipid nanoparticle platforms that support molecular encapsulation and functional presentation. Herein, we introduce various classes of lipid nanoparticle technology and critically examine the latest progress in utilizing lipid nanoparticles to deliver fatty acids and monoglycerides in order to treat medical diseases related to infectious pathogens, cancer, and inflammation. Particular emphasis is placed on understanding how nanoparticle structure is related to biological function in terms of mechanism, potency, selectivity, and targeting. We also discuss translational opportunities and regulatory needs for utilizing lipid nanoparticles to deliver fatty acids and monoglycerides, including unmet clinical opportunities.
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