期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 22, 期 17, 页码 -出版社
MDPI
DOI: 10.3390/ijms22179112
关键词
nerve growth factor; lung; coronavirus disease 2019; pathway
资金
- National Natural Science Foundation of China [82002909]
- Chengdu Medical College Research Foundation [KYPY-20-01]
- Graduate Scientific research and Innovation Foundation of Chongqing, China [CYB20069]
NGF plays a crucial role in the occurrence and development of various lung diseases by changing protein expression levels and mediating cell function. Anti-NGF may be used in future therapeutic strategies for lung diseases.
The lungs play a very important role in the human respiratory system. However, many factors can destroy the structure of the lung, causing several lung diseases and, often, serious damage to people's health. Nerve growth factor (NGF) is a polypeptide which is widely expressed in lung tissues. Under different microenvironments, NGF participates in the occurrence and development of lung diseases by changing protein expression levels and mediating cell function. In this review, we summarize the functions of NGF as well as some potential underlying mechanisms in pulmonary fibrosis (PF), coronavirus disease 2019 (COVID-19), pulmonary hypertension (PH), asthma, chronic obstructive pulmonary disease (COPD), and lung cancer. Furthermore, we highlight that anti-NGF may be used in future therapeutic strategies.
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