4.7 Review

Natural Killer Cells and Type 1 Innate Lymphoid Cells in Hepatocellular Carcinoma: Current Knowledge and Future Perspectives

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Multidisciplinary Sciences

Intratumoural immune heterogeneity as a hallmark of tumour evolution and progression in hepatocellular carcinoma

Phuong H. D. Nguyen et al.

Summary: The study reveals significant immune intratumoural heterogeneity in hepatocellular carcinomas, which is closely associated with tumor evolution and poor clinical outcomes. Tumors with high immune heterogeneity demonstrate an immune suppressive microenvironment, indicating a complex interplay between tumor and immune system during disease progression.

NATURE COMMUNICATIONS (2021)

Review Oncology

Tumor-Infiltrating Natural Killer Cells

Beatriz Cozar et al.

Summary: NK cells play a crucial role in immune responses to tumors by killing target cells and producing cytokines, but they can become dysfunctional in the immunosuppressive tumor microenvironment. This article provides an overview of NK tumor infiltration and surveillance, as well as the mechanisms by which NK cells become dysfunctional.

CANCER DISCOVERY (2021)

Article Medicine, General & Internal

Hepatocellular carcinoma

Josep M. Llovet et al.

Summary: Liver cancer, particularly hepatocellular carcinoma (HCC), poses a significant global health challenge with rising incidence projected to exceed 1 million cases by 2025. Infection by hepatitis B and C viruses remains a major risk factor for HCC, while non-alcoholic steatohepatitis is emerging as a more common risk factor in Western countries. Advances in systemic therapies for HCC, including immunotherapies and targeted therapies, are expected to revolutionize the management of this disease.

NATURE REVIEWS DISEASE PRIMERS (2021)

Review Immunology

Natural killers or ILC1s? That is the question

Cyril Seillet et al.

Summary: ILC1 and NK cells share common features but have great heterogeneity in tissues, posing a challenge in distinguishing between the two cell types.

CURRENT OPINION IN IMMUNOLOGY (2021)

Review Gastroenterology & Hepatology

Locoregional therapies in the era of molecular and immune treatments for hepatocellular carcinoma

Josep M. Llovet et al.

Summary: Locoregional therapies, including local ablation and transarterial chemoembolization, play a crucial role in the management of hepatocellular carcinoma. Recent studies have shown potential benefits of combining these local therapies with systemic treatments, such as molecular therapies, to enhance therapeutic effects.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2021)

Article Cell Biology

Intratumor Regulatory Noncytotoxic NK Cells in Patients with Hepatocellular Carcinoma

Alessandra Zecca et al.

Summary: The study identified different subsets of NK cells infiltrating HCC, including non-liver-resident cells that coexpressed CD49a and Eomes, showing reduced cytotoxic potential. This NK cell subset likely plays a regulatory role in proangiogenic function.
Article Oncology

Retinoids Decrease Soluble MICA Concentration by Inhibiting the Enzymatic Activity of ADAM9 and ADAM10

Yumi Otoyama et al.

Summary: The study found that suppressing MICA sheddase can decrease sMICA levels and effectively eliminate cancer cells. Treatment with retinoids can reduce sMICA levels in human HCC cells, indicating potential therapeutic effects.

ANTICANCER RESEARCH (2021)

Article Oncology

Phase I Trial of N-803, an IL15 Receptor Agonist, with Rituximab in Patients with Indolent Non-Hodgkin Lymphoma

Jennifer A. Foltz et al.

Summary: The combination therapy of N-803 with rituximab demonstrated safety and durable clinical responses in patients with indolent non-Hodgkin lymphoma, including rituximab-refractory patients. Analysis using CITE-seq revealed altered molecular programs in NK cells and monocytes post-treatment, suggesting the potential for further investigation of N-803 in combination with immunotherapies.

CLINICAL CANCER RESEARCH (2021)

Article Multidisciplinary Sciences

Liver type 1 innate lymphoid cells develop locally via an interferon-γ-dependent loop

Lu Bai et al.

Summary: Research indicates that the adult mouse liver contains lineage-CD122(+)CD49a(+) progenitor cells for liver ILC1s derived from fetal liver. The production of IFN-gamma by liver ILC1s themselves promotes their development in situ, emphasizing the role of extramedullary hematopoiesis in liver immune composition.

SCIENCE (2021)

Review Immunology

Natural Killer Cells and Regulatory T Cells Cross Talk in Hepatocellular Carcinoma: Exploring Therapeutic Options for the Next Decade

Amber G. Bozward et al.

Summary: Despite advancements in immunotherapy, treating HCC remains challenging. Research is needed to develop novel NK cell-targeted immunotherapy and control Treg frequency and function in HCC. Combining GMP-NK cell immunotherapy with CPI targeting NK and CD8 T cells may offer a promising therapeutic option.

FRONTIERS IN IMMUNOLOGY (2021)

Review Immunology

Insights Into Human Intrahepatic NK Cell Function From Single Cell RNA Sequencing Datasets

Grainne Jameson et al.

Summary: This review explores the potential novel functions of human liver-resident NK cells identified in scRNA-seq studies and identifies up-regulated and down-regulated genes associated with these cell clusters.

FRONTIERS IN IMMUNOLOGY (2021)

Review Immunology

Natural killer cell engagers in cancer immunotherapy: Next generation of immuno-oncology treatments

Olivier Demaria et al.

Summary: Immuno-oncology is revolutionizing cancer treatment by inducing the immune system to recognize and eliminate tumor cells. Despite successes, alternative strategies are needed to broaden and strengthen anti-tumor immune responses.

EUROPEAN JOURNAL OF IMMUNOLOGY (2021)

Article Multidisciplinary Sciences

Conventional NK cells and tissue-resident ILC1s join forces to control liver metastasis

Laura Ducimetiere et al.

Summary: This study found that innate lymphocyte subpopulations cNKs and trILC1s play nonredundant roles in controlling liver metastasis seeding and outgrowth, respectively, and may contribute to developing therapies involving hepatic innate cells.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Review Oncology

CAR-NK Cell: A New Paradigm in Tumor Immunotherapy

Faroogh Marofi et al.

Summary: CAR-NK cells, as an emerging cancer treatment, have various advantages in cancer immunotherapy, including better safety and adaptability, and the ability to improve attack on tumors and eliminate resistance. By targeting different antigens, CAR-NK cells are expected to achieve more effective anti-tumor responses.

FRONTIERS IN ONCOLOGY (2021)

Article Oncology

Peptide: MHC-based DNA vaccination strategy to activate natural killer cells by targeting killer cell immunoglobulin-like receptors

Pauline Rettman et al.

Summary: This study demonstrates the feasibility of a peptide-based KIR-targeting vaccine strategy to activate NK cells and enhance antitumor responses. The DNA vaccine upregulated genes associated with cellular metabolism and downregulated genes related to immune cell maturation. Vaccination led to enhanced antitumor responses against melanoma cells and a tumor model expressing the KIR2DS2 ligand HLA-C*0102.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

Article Gastroenterology & Hepatology

Single-cell RNA sequencing of human liver reveals hepatic stellate cell heterogeneity

Valery L. Payen et al.

Summary: This study used single-cell RNA sequencing to unravel the heterogeneity of human liver cells, particularly hepatocytes and hepatic stellate cells. The research revealed the existence of different cell populations in the liver with unique gene expression signatures and distinct intralobular localisation. These findings suggest the importance of metabolic zonation in determining transcriptomic heterogeneity of hepatocytes and highlight the diverse nature of hepatic stellate cells in the human liver.

JHEP REPORTS (2021)

Article Oncology

IL-15 superagonist N-803 improves IFNγ production and killing of leukemia and ovarian cancer cells by CD34+ progenitor-derived NK cells

J. M. R. Van der Meer et al.

Summary: N-803 is a promising IL-15-based compound that enhances HPC-NK cell expansion and functionality both in vitro and in vivo. Adding N-803 to HPC-NK cell therapy could potentially improve cancer immunotherapy.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2021)

Review Gastroenterology & Hepatology

Challenges of combination therapy with immune checkpoint inhibitors for hepatocellular carcinoma

Ann-Lii Cheng et al.

JOURNAL OF HEPATOLOGY (2020)

Article Gastroenterology & Hepatology

Tolerogenic properties of liver macrophages in non-alcoholic steatohepatitis

Lorenzo A. Orci et al.

LIVER INTERNATIONAL (2020)

Review Gastroenterology & Hepatology

Tumour evolution in hepatocellular carcinoma

Amanda J. Craig et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2020)

Review Oncology

Tumor intrinsic and extrinsic immune functions of CD155

Jake. S. O'Donnell et al.

SEMINARS IN CANCER BIOLOGY (2020)

Review Cell Biology

The Function of the HGF/c-Met Axis in Hepatocellular Carcinoma

Haiyu Wang et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

Review Immunology

NKG2D Ligand Shedding in Response to Stress: Role of ADAM10

Alessandra Zingoni et al.

FRONTIERS IN IMMUNOLOGY (2020)

Article Medicine, General & Internal

Association of Aspirin with Hepatocellular Carcinoma and Liver-Related Mortality

Tracey G. Simon et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Medicine, General & Internal

Atezolizumab plus Bevacizumab in Unresectable Hepatocellular Carcinoma

Richard S. Finn et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Oncology

ULBP1 Is Elevated in Human Hepatocellular Carcinoma and Predicts Outcome

Nicholas J. W. Easom et al.

FRONTIERS IN ONCOLOGY (2020)

Article Multidisciplinary Sciences

Efficacy of anti-CD147 chimeric antigen receptors targeting hepatocellular carcinoma

Hsiang-chi Tseng et al.

NATURE COMMUNICATIONS (2020)

Article Biochemistry & Molecular Biology

A single cell atlas of the human liver tumor microenvironment

Hassan Massalha et al.

MOLECULAR SYSTEMS BIOLOGY (2020)

Review Hematology

Natural killer cell engineering - a new hope for cancer immunotherapy

Cheng-Yu Lin et al.

SEMINARS IN HEMATOLOGY (2020)

Article Geriatrics & Gerontology

Tumor-Derived Soluble MICA Obstructs the NKG2D Pathway to Restrain NK Cytotoxicity

Qizhi Luo et al.

AGING AND DISEASE (2020)

Article Oncology

A framework for advancing our understanding of cancer-associated fibroblasts

Erik Sahai et al.

NATURE REVIEWS CANCER (2020)

Review Immunology

Sensing of physiological regulators by innate lymphoid cells

Cyril Seillet et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2019)

Article Biochemistry & Molecular Biology

Cytotoxicity of Human Hepatic Intrasinusoidal CD56bright Natural Killer Cells against Hepatocellular Carcinoma Cells

Shin Hwang et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Oncology

Modulation of NK cells with checkpoint inhibitors in the context of cancer immunotherapy

Beatriz Sanchez-Correa et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2019)

Review Biochemistry & Molecular Biology

The Role of Fibrosis and Liver-Associated Fibroblasts in the Pathogenesis of Hepatocellular Carcinoma

Jacopo Baglieri et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Medicine, Research & Experimental

Blocking expression of inhibitory receptor NKG2A overcomes tumor resistance to NK cells

Takahiro Kamiya et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

Review Medicine, General & Internal

Hepatocellular Carcinoma

Augusto Villanueva

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Review Immunology

Hide and seek: Plasticity of innate lymphoid cells in cancer

Tobias Bald et al.

SEMINARS IN IMMUNOLOGY (2019)

Review Oncology

Turning the Tide Against Regulatory T Cells

SeongJun Han et al.

FRONTIERS IN ONCOLOGY (2019)

Article Biochemistry & Molecular Biology

Multifunctional Natural Killer Cell Engagers Targeting NKp46 Trigger Protective Tumor Immunity

Laurent Gauthier et al.

Article Multidisciplinary Sciences

A human liver cell atlas reveals heterogeneity and epithelial progenitors

Nadim Aizarani et al.

NATURE (2019)

Article Gastroenterology & Hepatology

A Phase 2 Study of Galunisertib (TGF-β1 Receptor Type I Inhibitor) and Sorafenib in Patients With Advanced Hepatocellular Carcinoma

R. K. Kelley et al.

CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY (2019)

Review Immunology

The Natural Cytotoxicity Receptors in Health and Disease

Alexander David Barrow et al.

FRONTIERS IN IMMUNOLOGY (2019)

Review Immunology

Innate Lymphoid Cells: Expression of PD-1 and Other Checkpoints in Normal and Pathological Conditions

Francesca Romana Merlotti et al.

FRONTIERS IN IMMUNOLOGY (2019)

Review Immunology

The Role of Myeloid-Derived Cells in the Progression of Liver Disease

Chris John Weston et al.

FRONTIERS IN IMMUNOLOGY (2019)

Article Biochemistry & Molecular Biology

Therapeutic blockade of activin-A improves NK cell function and antitumor immunity

Jai Rautela et al.

SCIENCE SIGNALING (2019)

Article Oncology

Role of regulatory T cells and checkpoint inhibition in hepatocellular carcinoma

Bettina Langhans et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2019)

Article Multidisciplinary Sciences

Resolving the fibrotic niche of human liver cirrhosis at single-cell level

P. Ramachandran et al.

NATURE (2019)

Review Multidisciplinary Sciences

Harnessing innate immunity in cancer therapy

Olivier Demaria et al.

NATURE (2019)

Article Immunology

Mitochondrial fragmentation limits NK cell-based tumor immunosurveillance

Xiaohu Zheng et al.

NATURE IMMUNOLOGY (2019)

Review Immunology

Liver-Mediated Adaptive Immune Tolerance

Meijuan Zheng et al.

FRONTIERS IN IMMUNOLOGY (2019)

Article Immunology

29-Color Flow Cytometry: Unraveling Human Liver NK Cell Repertoire Diversity

Iva Filipovic et al.

FRONTIERS IN IMMUNOLOGY (2019)

Review Immunology

2B4 and CD48: A powerful couple of the immune system

Hadas Pahima et al.

CLINICAL IMMUNOLOGY (2019)

Review Immunology

The Emergence of Natural Killer Cells as a Major Target in Cancer Immunotherapy

Fernando Souza-Fonseca-Guimaraes et al.

TRENDS IN IMMUNOLOGY (2019)

Review Oncology

Adoptive cell transfer therapy for hepatocellular carcinoma

Renyu Zhang et al.

FRONTIERS OF MEDICINE (2019)

Article Biochemistry & Molecular Biology

Natural Killer Cells Control Tumor Growth by Sensing a Growth Factor

Alexander D. Barrow et al.

Review Immunology

Mouse models for the study of fate and function of innate lymphoid cells

Sascha Cording et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2018)

Article Medicine, General & Internal

Cabozantinib in Patients with Advanced and Progressing Hepatocellular Carcinoma

G. K. Abou-Alfa et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Multidisciplinary Sciences

Antibody-mediated inhibition of MICA and MICB shedding promotes NK cell-driven tumor immunity

Lucas Ferrari de Andrade et al.

SCIENCE (2018)

Review Immunology

Activating and inhibitory receptors expressed on innate lymphoid cells

Sophie Guia et al.

SEMINARS IN IMMUNOPATHOLOGY (2018)

Review Gastroenterology & Hepatology

Hepatic Dendritic Cells, the Tolerogenic Liver Environment, and Liver Disease

Lei Dou et al.

SEMINARS IN LIVER DISEASE (2018)

Article Multidisciplinary Sciences

The immune contexture of hepatocellular carcinoma predicts clinical outcome

Friedrich Foerster et al.

SCIENTIFIC REPORTS (2018)

Article Immunology

IL-15 Overcomes Hepatocellular Carcinoma-Induced NK Cell Dysfunction

Nicholas J. W. Easom et al.

FRONTIERS IN IMMUNOLOGY (2018)

Review Biochemistry & Molecular Biology

Innate Lymphoid Cells: 10 Years On

Eric Vivier et al.

Review Oncology

Molecular therapies and precision medicine for hepatocellular carcinoma

Josep M. Llovet et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2018)

Review Biochemistry & Molecular Biology

Natural Killer Cell Dysfunction in Hepatocellular Carcinoma: Pathogenesis and Clinical Implications

Pil Soo Sung et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Article Multidisciplinary Sciences

Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations

Sonya A. MacParland et al.

NATURE COMMUNICATIONS (2018)

Review Immunology

Natural killer cells and other innate lymphoid cells in cancer

Laura Chiossone et al.

NATURE REVIEWS IMMUNOLOGY (2018)

Review Immunology

TIGIT and CD96: new checkpoint receptor targets for cancer immunotherapy

William C. Dougall et al.

IMMUNOLOGICAL REVIEWS (2017)

Article Immunology

Cutting Edge: Human CD49e- NK Cells Are Tissue Resident in the Liver

Han Xian Aw Yeang et al.

JOURNAL OF IMMUNOLOGY (2017)

Article Multidisciplinary Sciences

IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti-viral activity

Martina Molgora et al.

NATURE (2017)

Article Multidisciplinary Sciences

Single-cell spatial reconstruction reveals global division of labour in the mammalian liver

Keren Bahar Halpern et al.

NATURE (2017)

Review Oncology

The immune contexture in cancer prognosis and treatment

Wolf H. Fridman et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2017)

Article Multidisciplinary Sciences

Delineation of an immunosuppressive gradient in hepatocellular carcinoma using high-dimensional proteomic and transcriptomic analyses

Valerie Chew et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Oncology

Myeloid-Derived Suppressor Cells

Dmitry I. Gabrilovich

CANCER IMMUNOLOGY RESEARCH (2017)

Review Immunology

Shaping Innate Lymphoid Cell Diversity

Qiutong Huang et al.

FRONTIERS IN IMMUNOLOGY (2017)

Article Oncology

Genetic engineering of human NK cells to express CXCR2 improves migration to renal cell carcinoma

Veronika Kremer et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2017)

Review Immunology

Innate lymphoid cells: major players in inflammatory diseases

Mikael Ebbo et al.

NATURE REVIEWS IMMUNOLOGY (2017)

Article Oncology

Augmented anti-tumor activity of NK-92 cells expressing chimeric receptors of TGF-βR II and NKG2D

Zhongjuan Wang et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2017)

Article Immunology

Complement factor P is a ligand for the natural killer cell-activating receptor NKp46

Emilie Narni-Mancinelli et al.

SCIENCE IMMUNOLOGY (2017)

Review Immunology

IL-15 signaling in NK cell cancer immunotherapy

Jai Rautela et al.

CURRENT OPINION IN IMMUNOLOGY (2017)

Review Immunology

SLAM family receptors in normal immunity and immune pathologies

Ning Wu et al.

CURRENT OPINION IN IMMUNOLOGY (2016)

Review Immunology

Innate lymphoid cells: parallel checkpoints and coordinate interactions with T cells

Nicholas D. Huntington et al.

CURRENT OPINION IN IMMUNOLOGY (2016)

Article Gastroenterology & Hepatology

Testosterone regulation of cyclin E kinase: A key factor in determining gender differences in hepatocarcinogenesis

Sharon Pok et al.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2016)

Article Immunology

The evolution of innate lymphoid cells

Eric Vivier et al.

NATURE IMMUNOLOGY (2016)

Review Immunology

The Nature of Myeloid-Derived Suppressor Cells in the Tumor Microenvironment

Vinit Kumar et al.

TRENDS IN IMMUNOLOGY (2016)

Article Oncology

Intratumoral CD3 and CD8 T-cell Densities Associated with Relapse-Free Survival in HCC

Andrew Gabrielson et al.

CANCER IMMUNOLOGY RESEARCH (2016)

Article Immunology

Type 1 innate Lymphoid Cell Biology: Lessons Learnt from Natural Killer Cells

Yuhao Jiao et al.

FRONTIERS IN IMMUNOLOGY (2016)

Article Multidisciplinary Sciences

CXCR6 marks a novel subset of T-betloEomeshi natural killer cells residing in human liver

Kerstin A. Stegmann et al.

SCIENTIFIC REPORTS (2016)

Review Chemistry, Multidisciplinary

Natural killer cell dysfunction in hepatocellular carcinoma and NK cell-based immunotherapy

Cheng Sun et al.

ACTA PHARMACOLOGICA SINICA (2015)

Article Immunology

IL-15 Superagonist-Mediated Immunotoxicity: Role of NK Cells and IFN-γ

Yin Guo et al.

JOURNAL OF IMMUNOLOGY (2015)

Article Immunology

Cutting Edge: Identification and Characterization of Human Intrahepatic CD49a+ NK Cells

Nicole Marquardt et al.

JOURNAL OF IMMUNOLOGY (2015)

Review Oncology

Tumor-infiltrating lymphocytes for the treatment of metastatic cancer

M. H. Geukes Foppen et al.

MOLECULAR ONCOLOGY (2015)

Review Multidisciplinary Sciences

Adoptive cell transfer as personalized immunotherapy for human cancer

Steven A. Rosenberg et al.

SCIENCE (2015)

Article Multidisciplinary Sciences

Tissue residency of innate lymphoid cells in lymphoid and nonlymphoid organs

Georg Gasteiger et al.

SCIENCE (2015)

Article Cell Biology

Clinical impact of the NKp30/B7-H6 axis in high-risk neuroblastoma patients

Michaela Semeraro et al.

Science Translational Medicine (2015)

Review Oncology

NKG2D Receptor and Its Ligands in Host Defense

Lewis L. Lanier

CANCER IMMUNOLOGY RESEARCH (2015)

Article Biochemistry & Molecular Biology

Differentiation of Type 1 ILCs from a Common Progenitor to All Helper-like Innate Lymphoid Cell Lineages

Christoph S. N. Klose et al.

Review Biochemistry & Molecular Biology

The Biological Function and Clinical Utilization of CD147 in Human Diseases: A Review of the Current Scientific Literature

Lijuan Xiong et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2014)

Article Medicine, Research & Experimental

Interactions between Siglec-7/9 receptors and ligands influence NK cell-dependent tumor immunosurveillance

Camilla Jandus et al.

JOURNAL OF CLINICAL INVESTIGATION (2014)

Article Immunology

Nfil3 is required for the development of all innate lymphoid cell subsets

Cyril Seillet et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2014)

Article Immunology

Differential Requirement for Nfil3 during NK Cell Development

Cyril Seillet et al.

JOURNAL OF IMMUNOLOGY (2014)

Article Immunology

Cutting Edge: Salivary Gland NK Cells Develop Independently of Nfil3 in Steady-State

Victor S. Cortez et al.

JOURNAL OF IMMUNOLOGY (2014)

Article Multidisciplinary Sciences

A committed precursor to innate lymphoid cells

Michael G. Constantinides et al.

NATURE (2014)

Article Multidisciplinary Sciences

Innate immunodeficiency following genetic ablation of Mcl1 in natural killer cells

Priyanka Sathe et al.

NATURE COMMUNICATIONS (2014)

Review Immunology

Controlling Natural Killer Cell Responses: Integration of Signals for Activation and Inhibition

Eric O. Long et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 31 (2013)

Article Medicine, Research & Experimental

Liver-resident NK cells confer adaptive immunity in skin-contact inflammation

Hui Peng et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

Article Immunology

Nfil3-independent lineage maintenance and antiviral response of natural killer cells

Matthew A. Firth et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2013)

Article Cell Biology

NCR3/NKp30 Contributes to Pathogenesis in Primary Sjogren's Syndrome

Sylvie Rusakiewicz et al.

SCIENCE TRANSLATIONAL MEDICINE (2013)

Article Immunology

Innate lymphoid cells - a proposal for uniform nomenclature

Hergen Spits et al.

NATURE REVIEWS IMMUNOLOGY (2013)

Article Oncology

Associations Between Infiltrating Lymphocyte Subsets and Hepatocellular Carcinoma

Cun-Li Guo et al.

ASIAN PACIFIC JOURNAL OF CANCER PREVENTION (2012)

Article Oncology

Interleukin-1β enhances the production of soluble MICA in human hepatocellular carcinoma

Keisuke Kohga et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2012)

Review Immunology

NK cell MHC class I specific receptors (KIR): from biology to clinical intervention

Ariane Thielens et al.

CURRENT OPINION IN IMMUNOLOGY (2012)

Article Biochemistry & Molecular Biology

Role of fibrogenic markers in chronic hepatitis C and associated hepatocellular carcinoma

N. E. El-Bassiouni et al.

MOLECULAR BIOLOGY REPORTS (2012)

Review Oncology

The immune contexture in human tumours: impact on clinical outcome

Wolf Herman Fridman et al.

NATURE REVIEWS CANCER (2012)

Article Biochemistry & Molecular Biology

Alternatively spliced NKp30 isoforms affect the prognosis of gastrointestinal stromal tumors

Nicolas F. Delahaye et al.

NATURE MEDICINE (2011)

Article Multidisciplinary Sciences

Fate mapping analysis of lymphoid cells expressing the NKp46 cell surface receptor

Emilie Narni-Mancinelli et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Hematology

Maturation of mouse NK cells is a 4-stage developmental program

Laura Chiossone et al.

Article Immunology

IL-15 trans-presentation promotes human NK cell development and differentiation in vivo

Nicholas D. Huntington et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2009)

Article Immunology

Nfil3/E4bp4 is required for the development and maturation of NK cells in vivo

Shintaro Kamizono et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2009)

Article Gastroenterology & Hepatology

Mechanism of T cell tolerance induction by murine hepatic Kupffer cells

Qiang You et al.

HEPATOLOGY (2008)

Article Immunology

TLR-dependent cross talk between human Kupffer cells and NK cells

Zhengkun Tu et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2008)

Review Immunology

Functions of natural killer cells

Eric Vivier et al.

NATURE IMMUNOLOGY (2008)

Article Medicine, General & Internal

Sorafenib in advanced hepatocellular carcinoma

Josep M. Llovet et al.

NEW ENGLAND JOURNAL OF MEDICINE (2008)

Review Gastroenterology & Hepatology

Liver: An organ with predominant innate immunity

Bin Gao et al.

HEPATOLOGY (2008)

Article Multidisciplinary Sciences

Distinct cell types control lymphoid subset development by means of IL-15 and IL-15 receptor α expression

KS Schluns et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Review Biochemistry & Molecular Biology

Roles of TGF-beta in hepatic fibrosis

AM Gressner et al.

FRONTIERS IN BIOSCIENCE-LANDMARK (2002)

Article Cell Biology

Hepatoimmunology: A perspective

IR Mackay

IMMUNOLOGY AND CELL BIOLOGY (2002)

Article Multidisciplinary Sciences

Rae1 and H60 ligands of the NKG2D receptor stimulate tumour immunity

A Diefenbach et al.

NATURE (2001)