4.7 Article

Dimerization of Human Angiogenin and of Variants Involved in Neurodegenerative Diseases

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Article Biochemistry & Molecular Biology

NMR Characterization of Angiogenin Variants and tRNAAla Products Impacting Aberrant Protein Oligomerization

Andrea Fagagnini et al.

Summary: Protein oligomerization is crucial for various physiological processes and diseases, with human Angiogenin (h-ANG) playing a significant role in this process. Mutations in h-ANG can affect the surrounding residues and active site residues differently. Additionally, there is ongoing debate regarding the structure adopted by RNA fragments after cleavage by h-ANG.

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