4.7 Review

The Role of HPA Axis and Allopregnanolone on the Neurobiology of Major Depressive Disorders and PTSD

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Summary: This paper explores the potential of neurosteroids and neurotrophic proteins as biomarkers for MDD and PTSD. Findings show that allopregnanolone levels are diminished in MDD and PTSD patients, while BDNF is reduced in these patients and depressed-like animals with lower neurosteroid levels. The proposed causal link between allopregnanolone levels and BDNF expression could serve as a biomarker axis for the diagnosis of both MDD and PTSD.

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