Therapies Targeted at Non-Coding RNAs in Prevention and Limitation of Myocardial Infarction and Subsequent Cardiac Remodeling-Current Experience and Perspectives

Myocardial infarction is one of the major causes of mortality worldwide and is a main cause of heart failure. This disease appears as a final point of atherosclerotic plaque progression, destabilization, and rupture. As a consequence of cardiomyocytes death during the infarction, the heart undergoes unfavorable cardiac remodeling, which results in its failure. Therefore, therapies aimed to limit the processes of atherosclerotic plaque progression, cardiac damage during the infarction, and subsequent remodeling are urgently warranted. A hopeful therapeutic option for the future medicine is targeting and regulating non-coding RNA (ncRNA), like microRNA, circular RNA (circRNA), or long non-coding RNA (lncRNA). In this review, the approaches targeted at ncRNAs participating in the aforementioned pathophysiological processes involved in myocardial infarction and their outcomes in preclinical studies have been concisely presented.

Automated summary

Myocardial infarction is a major cause of mortality worldwide, mainly caused by the progression, destabilization, and rupture of atherosclerotic plaques. Targeted therapies aimed at limiting plaque progression, reducing cardiac damage, and preventing cardiac remodeling are urgently needed for treating this disease. Targeting and regulating non-coding RNAs like microRNA, circular RNA, and long non-coding RNA show promise as potential therapeutic options for the future medicine.