4.7 Review

Targeting Leukemic Stem Cells in Chronic Myeloid Leukemia: Is It Worth the Effort?

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Biochemistry & Molecular Biology

Targeting Abnormal Hematopoietic Stem Cells in Chronic Myeloid Leukemia and Philadelphia Chromosome-Negative Classical Myeloproliferative Neoplasms

Yammy Yung et al.

Summary: Myeloproliferative neoplasms (MPNs) are hematopoietic stem cell disorders characterized by clonal myeloproliferation. Despite effective treatment, complete eradication of CML/MPN stem cells is rare. Novel agents and combination therapy have potential to target abnormal hematopoietic stem cells and the sustaining bone marrow microenvironment in CML and MPNs.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Pharmacology & Pharmacy

miRNome profiling of LSC-enriched CD34+CD38-CD26+ fraction in Ph+ CML-CP samples from Argentinean patients: a potential new pharmacogenomic tool

Maria Sol Ruiz et al.

Summary: This study analyzed the miRNome of LSC and HSC-enriched fractions from CML patients, revealing a global decrease in microRNA levels and potential silencing of multiple non-coding RNAs. Despite the absence of BCR-ABL1 expression, an altered miRNome was observed in HSC. The findings suggest a potential role of microRNA in metabolic vulnerabilities in LSC and provide valuable data for future studies and therapeutic strategies.

FRONTIERS IN PHARMACOLOGY (2021)

Article Oncology

Target Inhibition of CBP Induced Cell Senescence in BCR-ABL-T315I Mutant Chronic Myeloid Leukemia

Ke Yang et al.

Summary: This study found that the high expression of CBP in CML cells, and down-regulation of CBP can promote the differentiation of CML cells and induce p53-dependent cell senescence, suggesting that CBP blockade can be a potential treatment for CML independent of the BCR-ABL mutation status.

FRONTIERS IN ONCOLOGY (2021)

Review Oncology

Improving outcomes in chronic myeloid leukemia through harnessing the immunological landscape

Ya-Ching Hsieh et al.

Summary: The immune dysfunction and immunosurveillance play crucial roles in achieving treatment-free remission (TFR) and deep molecular response (DMR) in chronic myeloid leukemia (CML). Targeting residual leukemic cells through novel immunotherapies and the restoration of immune surveillance via therapies like tyrosine kinase inhibitors (TKIs) are key strategies to improve TFR outcomes. Understanding the immunological landscape in CML is essential for developing novel therapies and repurposing older treatments to enhance TFR outcomes.

LEUKEMIA (2021)

Article Oncology

Targeting Chronic Myeloid Leukemia Stem/Progenitor Cells Using Venetoclax-Loaded Immunoliposome

Mohammad Houshmand et al.

Summary: The study successfully targeted CML LSCs/progenitor cells by designing a liposome conjugated with Begelomab and loaded with venetoclax, leading to improved treatment outcomes. The system demonstrated the ability to eliminate CD26+ LSCs/progenitor cells while sparing CD26- cells. Treatment of patient samples with IL-VX significantly reduced the number of CD26+ cells.

CANCERS (2021)

Review Oncology

Treatment-free remission in patients with chronic myeloid leukaemia

David M. Ross et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2020)

Article Medical Laboratory Technology

Flow Cytometry Assessment of CD26+ Leukemic Stem Cells in Peripheral Blood: A Simple and Rapid New Diagnostic Tool for Chronic Myeloid Leukemia

Donatella Raspadori et al.

CYTOMETRY PART B-CLINICAL CYTOMETRY (2019)

Review Biochemistry & Molecular Biology

Dietary Phytochemicals Targeting Cancer Stem Cells

Alena Liskova et al.

MOLECULES (2019)

Article Medicine, Research & Experimental

SIRT1 regulates metabolism and leukemogenic potential in CML stem cells

Ajay Abraham et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

Review Biochemistry & Molecular Biology

Immunotherapy-Based Targeting and Elimination of Leukemic Stem Cells in AML and CML

Peter Valent et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Biochemistry & Molecular Biology

Mechanisms of Disease Progression and Resistance to Tyrosine Kinase Inhibitor Therapy in Chronic Myeloid Leukemia: An Update

Luana Bavaro et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Biochemistry & Molecular Biology

Single-cell transcriptomics uncovers distinct molecular signatures of stem cells in chronic myeloid leukemia

Alice Giustacchini et al.

NATURE MEDICINE (2017)

Article Biochemistry & Molecular Biology

CBP/catenin antagonist safely eliminates drug-resistant leukemia-initiating cells

Y. Zhao et al.

ONCOGENE (2016)

Article Cell & Tissue Engineering

ADAR1 Activation Drives Leukemia Stem Cell Self-Renewal by Impairing Let-7 Biogenesis

Maria Anna Zipeto et al.

CELL STEM CELL (2016)

Article Medicine, Research & Experimental

Heterogeneity of leukemia-initiating capacity of chronic myelogenous leukemia stem cells

Bin Zhang et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

Article Multidisciplinary Sciences

Dual targeting of p53 and c-MYC selectively eliminates leukaemic stem cells

Sheela A. Abraham et al.

NATURE (2016)

Article Oncology

Best Practices in Chronic Myeloid Leukemia Monitoring and Management

Simona Soverini et al.

ONCOLOGIST (2016)

Article Cell Biology

Combined targeting of BCL-2 and BCR-ABL tyrosine kinase eradicates chronic myeloid leukemia stem cells

Bing Z. Carter et al.

SCIENCE TRANSLATIONAL MEDICINE (2016)

Review Biochemistry & Molecular Biology

Phytochemicals as Innovative Therapeutic Tools against Cancer Stem Cells

Emanuele-Salvatore Scarpa et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2015)

Article Biochemistry & Molecular Biology

Fenretinide Targets Chronic Myeloid Leukemia Stem/Progenitor Cells by Regulation of Redox Signaling

Yanzhi Du et al.

ANTIOXIDANTS & REDOX SIGNALING (2014)

Review Medicine, General & Internal

DPPIV (CD26) as a novel stem cell marker in Ph plus chronic myeloid leukaemia

Peter Valent et al.

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2014)

Article Medicine, Research & Experimental

Arachidonate 15-lipoxygenase is required for chronic myeloid leukemia stem cell survival

Yaoyu Chen et al.

JOURNAL OF CLINICAL INVESTIGATION (2014)

Article Oncology

Molecular Monitoring

Simona Soverini et al.

CURRENT HEMATOLOGIC MALIGNANCY REPORTS (2014)

Review Oncology

Homoharringtonine/Omacetaxine Mepesuccinate: The Long and Winding Road to Food and Drug Administration Approval

Hagop M. Kantarjian et al.

CLINICAL LYMPHOMA MYELOMA & LEUKEMIA (2013)

Article Medicine, Research & Experimental

PP2A-activating drugs selectively eradicate TKI-resistant chronic myeloid leukemic stem cells

Paolo Neviani et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

Article Oncology

Targeting Primitive Chronic Myeloid Leukemia Cells by Effective Inhibition of a New AHI-1BCR-ABL-JAK2 Complex

Min Chen et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2013)

Article Medicine, Research & Experimental

CD27 signaling on chronic myelogenous leukemia stem cells activates Wnt target genes and promotes disease progression

Christian Schuerch et al.

JOURNAL OF CLINICAL INVESTIGATION (2012)

Review Biotechnology & Applied Microbiology

Autophagy modulation as a potential therapeutic target for diverse diseases

David C. Rubinsztein et al.

NATURE REVIEWS DRUG DISCOVERY (2012)

Review Cell & Tissue Engineering

Metabolic Regulation of Hematopoietic Stem Cells in the Hypoxic Niche

Toshio Suda et al.

CELL STEM CELL (2011)

Article Medicine, Research & Experimental

Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity

Amie S. Corbin et al.

JOURNAL OF CLINICAL INVESTIGATION (2011)

Article Immunology

The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance

Monika Mortensen et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2011)

Article Multidisciplinary Sciences

Isolation and killing of candidate chronic myeloid leukemia stem cells by antibody targeting of IL-1 receptor accessory protein

Marcus Jaras et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Review Oncology

Imatinib mesylate for the treatment of chronic myeloid leukemia

Simona Soverini et al.

EXPERT REVIEW OF ANTICANCER THERAPY (2008)

Article Multidisciplinary Sciences

PML targeting eradicates quiescent leukaemia-initiating cells

Keisuke Ito et al.

NATURE (2008)

Article Biochemistry & Molecular Biology

Requirement for CD44 in homing and engraftment of BCR-ABL-expressing leukemic stem cells

Daniela S. Krause et al.

NATURE MEDICINE (2006)

Article Multidisciplinary Sciences

PML inhibits HIF-1α translation and neoangiogenesis through repression of mTOR

Rosa Bernardi et al.

NATURE (2006)

Article Multidisciplinary Sciences

A role for Wnt signalling in self-renewal of haematopoietic stem cells

T Reya et al.

NATURE (2003)

Review Biochemistry & Molecular Biology

The role of PML in tumor suppression

P Salomoni et al.