期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 22, 期 13, 页码 -出版社
MDPI
DOI: 10.3390/ijms22136683
关键词
competitive exclusion product; Aviguard (R); gut microbiota; enteropathogenic infection; Campylobacter jejuni; immune-modulatory effects; microbiota-depleted IL-10(-/-) mice; acute campylobacteriosis model; host-pathogen interaction; probiotic formulations
资金
- German Federal Ministries of Education and Research (BMBF) [IP7/01KI2007D]
- Federal Ministry for Economic Affairs and Energy [ZF4117908 AJ8]
The study demonstrates that Aviguard (R) has potent disease-alleviating effects in acute C. jejuni-induced murine enterocolitis, indicating it may be a promising probiotic treatment option for severe campylobacteriosis in humans.
Prevalences of Campylobacter (C.) jejuni infections are progressively rising globally. Given that probiotic feed additives, such as the commercial product Aviguard (R), have been shown to be effective in reducing enteropathogens, such as Salmonella, in vertebrates, including livestock, we assessed potential anti-pathogenic and immune-modulatory properties of Aviguard (R) during acute C. jejuni-induced murine enterocolitis. Therefore, microbiota-depleted IL-10(-/-) mice were infected with C. jejuni strain 81-176 by gavage and orally treated with Aviguard (R) or placebo from day 2 to 4 post-infection. The applied probiotic bacteria could be rescued from the intestinal tract of treated mice, but with lower obligate anaerobic bacterial counts in C. jejuni-infected as compared to non-infected mice. Whereas comparable gastrointestinal pathogen loads could be detected in both groups until day 6 post-infection, Aviguard (R) treatment resulted in improved clinical outcome and attenuated apoptotic cell responses in infected large intestines during acute campylobacteriosis. Furthermore, less distinct pro-inflammatory immune responses could be observed not only in the intestinal tract, but also in extra-intestinal compartments on day 6 post-infection. In conclusion, we show here for the first time that Aviguard (R) exerts potent disease-alleviating effects in acute C. jejuni-induced murine enterocolitis and might be a promising probiotic treatment option for severe campylobacteriosis in humans.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据