期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 22, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/ijms22126313
关键词
ART; autophagic; cloning; embryogenesis; oogenesis; reproduction; reprogramming; spermatozoa
资金
- Sao Paulo Research Foundation (FAPESP) [2017/20125-3, 2017/13082-6]
- Coordination for the Improvement of Higher Level Education Personnel (CAPES) [001]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [17/20125-3] Funding Source: FAPESP
Mammals have developed mechanisms to cope with environmental stressors throughout their lifespan, including the autophagy pathway, which helps repair damage and reallocates resources for long-term survival. Autophagy plays a key role in mammalian gametogenesis, fertilization, and preimplantation embryonic development, affecting physiological processes and responses to stressors.
Mammals face environmental stressors throughout their lifespan, which may jeopardize cellular homeostasis. Hence, these organisms have acquired mechanisms to cope with stressors by sensing, repairing the damage, and reallocating resources to increase the odds of long-term survival. Autophagy is a pro-survival lysosome-mediated cytoplasm degradation pathway for organelle and macromolecule recycling. Furthermore, autophagy efflux increases, and this pathway becomes idiosyncratic depending upon developmental and environmental contexts. Mammalian germ cells and preimplantation embryos are attractive models for dissecting autophagy due to their metastable phenotypes during differentiation and exposure to varying environmental cues. The aim of this review is to explore autophagy during mammalian gametogenesis, fertilization and preimplantation embryonic development by contemplating its physiological role during development, under key stressors, and within the scope of assisted reproduction technologies.
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