期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 22, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/ijms22126481
关键词
COVID-19; siphonaxanthin; fucoxanthin; carotenoid; seaweed; antiviral activity; molecular docking
资金
- Jeonnam Provincial Government
- Wando County
This study found significant antiviral activity against SARS-CoV-2 pseudovirus entry for siphonaxanthin from Codium fragile, while fucoxanthin from Undaria pinnatifida sporophyll did not exhibit this effect. Predicted acute toxicities were relatively low, with indications of gastrointestinal absorption for these marine carotenoids.
The marine carotenoids fucoxanthin and siphonaxanthin are powerful antioxidants that are attracting focused attention to identify a variety of health benefits and industry applications. In this study, the binding energy of these carotenoids with the SARS-CoV-2 Spike-glycoprotein was predicted by molecular docking simulation, and their inhibitory activity was confirmed with SARS-CoV-2 pseudovirus on HEK293 cells overexpressing angiotensin-converting enzyme 2 (ACE2). Siphonaxanthin from Codium fragile showed significant antiviral activity with an IC50 of 87.4 mu M against SARS-CoV-2 pseudovirus entry, while fucoxanthin from Undaria pinnatifida sporophyll did not. The acute toxicities were predicted to be relatively low, and pharmacokinetic predictions indicate GI absorption. Although further studies are needed to elucidate the inhibition of viral infection by siphonaxanthin, these results provide useful information in the application of these marine carotenoids for the treatment and prevention of COVID-19.
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