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M. D. Cappellini et al.
LANCET (2008)
Comparison of the effects of pioglitazone and metformin on hepatic and extra-hepatic insulin action in people with type 2 diabetes
Rita Basu et al.
DIABETES (2008)
Impaired myocardial metabolic reserve and substrate selection flexibility during stress in patients with idiopathic dilated cardiomyopathy
Danilo Neglia et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2007)
Greater glycogen utilization during β1- than β2-adrenergic receptor stimulation in the isolated perfused rat heart
Patrick McConville et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2007)
Adrenal adrenoceptors in heart failure: fine-tuning cardiac stimulation
Anastasios Lymperopoulos et al.
TRENDS IN MOLECULAR MEDICINE (2007)
Nuclear receptors PPARβ/δ and PPARα direct distinct metabolic regulatory programs in the mouse heart
Eileen M. Burkart et al.
JOURNAL OF CLINICAL INVESTIGATION (2007)
Green tea modulates α1-Adrenergic stimulated glucose transport in cultured rat cardiomyocytes
Cristina Angeloni et al.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2007)
Epinephrine is required for normal cardiovascular responses to stress in the phenylethanolamine n-methyltransferase knockout mouse
Xuping Bao et al.
CIRCULATION (2007)
Cardiac energy metabolism in obesity
Gary D. Lopaschuk et al.
CIRCULATION RESEARCH (2007)
A double-blind randomized multicentre clinical trial to evaluate the efficacy and safety of two doses of etomoxir in comparison with placebo in patients with moderate congestive heart failure: the ERGO (etomoxir for the recovery of glucose oxidation) study
Christian J. F. Holubarsch et al.
CLINICAL SCIENCE (2007)
Upregulation of glucose-6-phosphate dehydrogenase and NAD(P)H oxidase activity increases oxidative stress in failing human heart
Rakhee S. Gupte et al.
JOURNAL OF CARDIAC FAILURE (2007)
Interleukin-6 directly increases glucose metabolism in resting human skeletal muscle
Stephan Glund et al.
DIABETES (2007)
The early anti-oxidant effect of carvedilol predicts the clinical course in congestive heart failure patients
Ehud Goldhammer et al.
JOURNAL OF CARDIOVASCULAR MEDICINE (2007)
Recruitment of compensatory pathways to sustain oxidative flux with reduced carnitine palmitoyltransferase I activity characterizes inefficiency in energy metabolism in hypertrophied hearts
Natalia Sorokina et al.
CIRCULATION (2007)
Mechanisms of disease - The failing heart - An engine out of fuel
Stefan Neubauer
NEW ENGLAND JOURNAL OF MEDICINE (2007)
Contribution of both Ca2+ entry and Ca2+ sensitization to the α1-adrenergic vasoconstriction of rat penile small arteries
Nuria Villalba et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2007)
Recent advances in the discovery of α1-adrenoceptor agonists
Michael J. Bishop
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2007)
Increased Ca2+ sensitivity and protein expression of SERCA 2a in situations of chronic beta(3)-adrenoceptor deficiency
Christoph Ziskoven et al.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2007)
Free fatty acid depletion acutely decreases cardiac work and efficiency in cardiomyopathic heart failure
Helena Tuunanen et al.
CIRCULATION (2006)
Influence of β-adrenoceptor blockade on the myocardial accumulation of fatty acid tracer and its intracellular metabolism in the heart after ischemia-reperfusion injury
Norio Igarashi et al.
CIRCULATION JOURNAL (2006)
Absence of malonyl coenzyme a decarboxylase in mice increases cardiac glucose oxidation and protects the heart from ischemic injury
Jason R. B. Dyck et al.
CIRCULATION (2006)
A randomized clinical trial of trimetazidine, a partial free fatty acid oxidation inhibitor, in patients with heart failure
Gabriele Fragasso et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2006)
Transgenic α1A-adrenergic activation limits post-infarct ventricular remodeling and dysfunction and improves survival
Xiao-Jun Du et al.
CARDIOVASCULAR RESEARCH (2006)
Glucose-6-phosphate dehydrogenase-derived NADPH fuels superoxide production in the failing heart
Sachin A. Gupte et al.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2006)
Prolonged AMPK activation increases the expression of fatty acid transporters in cardiac myocytes and perfused hearts
Adrian Chabowski et al.
MOLECULAR AND CELLULAR BIOCHEMISTRY (2006)
Trends in prevalence and outcome of heart failure with preserved ejection fraction
Theophilus E. Owan et al.
NEW ENGLAND JOURNAL OF MEDICINE (2006)
Fatty acids attenuate insulin regulation of 5′-AMP-activated protein kinase and insulin cardioprotection after ischemia
Clifford D. L. Folmes et al.
CIRCULATION RESEARCH (2006)
Anti hypertensive treatment with beta-blockers and the spectrum of glycaemic control
P. A. Sarafidis et al.
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE (2006)
Energy deficiency in the failing heart: Linking increased reactive oxygen species and disruption of oxidative phosphorylation rate
Freya L. Sheeran et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2006)
Carvedilol inhibits mitochondrial oxygen consumption and superoxide production during calcium overload in isolated heart mitochondria
R Kametani et al.
CIRCULATION JOURNAL (2006)
AMP-activated protein kinase activation by adrenoceptors in L6 skeletal muscle cells -: Mediation by α1-adrenoceptors causing glucose uptake
DS Hutchinson et al.
DIABETES (2006)
Multiple signalling pathways involved in β2-adrenoceptor-mediated glucose uptake in rat skeletal muscle cells
J Nevzorova et al.
BRITISH JOURNAL OF PHARMACOLOGY (2006)
Subtype-specific alpha(1)- and beta-adrenoceptor signaling in the heart
Rui-Ping Xiao et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2006)
Carvedilol blocks beta(2)- more than beta(1)-adrenoceptors in human heart
P Molenaar et al.
CARDIOVASCULAR RESEARCH (2006)
Metabolic modulation with perhexiline in chronic heart failure - A randomized, controlled trial of short-term use of a novel treatment
L Lee et al.
CIRCULATION (2005)
Both α1A- and α1B-adrenergic receptors crosstalk to downregulate β1-ARs in mouse heart:: coupling to differential PTX-sensitive pathways
BR Rorabaugh et al.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2005)
Long-chain fatty acid uptake and FAT/CD36 translocation in heart and skeletal muscle
DPY Koonen et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2005)
Temporal dynamics of inotropic, chronotropic, and metabolic responses during β1- and β2-AR stimulation in the isolated, perfused rat heart
P McConville et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2005)
Increased reactive oxygen species production and functional alterations in antioxidant enzymes in human failing myocardium
F Sam et al.
JOURNAL OF CARDIAC FAILURE (2005)
G-protein-coupled receptor kinase activity in human heart failure:: Effects of β-adrenoceptor blockade
K Leineweber et al.
CARDIOVASCULAR RESEARCH (2005)
β-Agonist stimulation produces changes in cardiac AMPK and coronary lumen LPL only during increased workload
D An et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2005)
Selective versus nonselective β-adrenergic receptor blockade in chronic heart failure:: differential effects on myocardial energy substrate utilization
A Al-Hesayen et al.
EUROPEAN JOURNAL OF HEART FAILURE (2005)
Alterations in alpha adrenoreceptor density and localization after mechanical left ventricular unloading with the jarvik flowmaker left ventricular assist device
A Grigore et al.
JOURNAL OF HEART AND LUNG TRANSPLANTATION (2005)
α1A-adrenoceptors activate glucose uptake in L6 muscle cells through a phospholipase C-, phosphatidylinositol-3 kinase-, and atypical protein kinase C-dependent pathway
DS Hutchinson et al.
ENDOCRINOLOGY (2005)
Effects of carvedilol on oxidative stress in polymorphonuclear and mononuclear cells in patients with essential hypertension
K Yasunari et al.
AMERICAN JOURNAL OF MEDICINE (2004)
Paradoxical downregulation of the glucose oxidation pathway despite enhanced flux in severe heart failure
B Lei et al.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2004)
Sympathetic regulation of glucose uptake by the α1-adrenoceptor in human obesity
M Flechtner-Mors et al.
OBESITY RESEARCH (2004)
Increased myocardial dysfunction after ischemia-reperfusion in mice lacking glucose-6-phosphate dehydrogenase
M Jain et al.
CIRCULATION (2004)
Ischemic preconditioning activates AMPK in a PKC-dependent manner and induces GLUT4 up-regulation in the late phase of cardioprotection
Y Nishino et al.
CARDIOVASCULAR RESEARCH (2004)
Heart failure with preserved left ventricular Systolic function - Epidemiology clinical characteristics and prognosis
K Hogg et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2004)
Impaired glucose homeostasis in mice lacking the α1b-adrenergic receptor subtype
R Burcelin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Carvedilol selectively inhibits oscillatory intracellular calcium changes evoked by human α1D- and α-1B-adrenergic receptors
T Koshimizu et al.
CARDIOVASCULAR RESEARCH (2004)
Beneficial effects of chronic pharmacological manipulation of β-adrenoreceptor subtype signaling in rodent dilated ischemic cardiomyopathy
I Ahmet et al.
CIRCULATION (2004)
Metabolic effects of carvedilol vs metoprolol in patients with type 2 diabetes mellitus and hypertension - A randomized controlled trial
GL Bakris et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2004)
A randomized crossover study to evaluate Ro 115-1240, a selective alpha(1A/1L)-adrenoceptor partial agonist in women with stress urinary incontinence
DM Musselman et al.
BJU INTERNATIONAL (2004)
Pharmacological characteristics of Ro 115-1240, a selective alpha(1A/1L)-adrenoceptor partial agonist: a potential therapy for stress urinary incontinence
DR Blue et al.
BJU INTERNATIONAL (2004)
Genetic enhancement of ventricular contractility protects against pressure-overload-induced cardiac dysfunction
XJ Du et al.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2004)
Cardiomyocyte-restricted peroxisome proliferator-activated receptor-δ deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathy
LH Cheng et al.
NATURE MEDICINE (2004)
Adrenergic receptor knockout mice: distinct functions of 9 receptor subtypes
M Philipp et al.
PHARMACOLOGY & THERAPEUTICS (2004)
Malonyl coenzyme a decarboxylase inhibition protects the ischemic heart by inhibiting fatty acid oxidation and stimulating glucose oxidation
JRB Dyck et al.
CIRCULATION RESEARCH (2004)
Mitochondrial formation of reactive oxygen species
JF Turrens
JOURNAL OF PHYSIOLOGY-LONDON (2003)
β3-adrenergic stimulation produces a decrease of cardiac contractility ex vivo in mice overexpressing the human β3-adrenergic receptor
G Tavernier et al.
CARDIOVASCULAR RESEARCH (2003)
Glucose-6-phosphate dehydrogenase modulates cytosolic redox status and contractile phenotype in adult cardiomyocytes
M Jain et al.
CIRCULATION RESEARCH (2003)
Differences in the bioenergetic response of the isolated perfused rat heart to selective β1- and β2-adrenergic receptor stimulation
P McConville et al.
CIRCULATION (2003)
β1-Adrenoceptor antibodies induce apoptosis in adult isolated cardiomyocytes
Y Staudt et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2003)
Cellular basis of abnormal calcium transients of failing human ventricular myocytes
V Piacentino et al.
CIRCULATION RESEARCH (2003)
α1-Adrenergic receptor responses in α1AB-AR knockout mouse hearts suggest the presence α1D-AR
L Turnbull et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2003)
Increased contribution of α1 vs. β-adrenoceptor-mediated inotropic response in rats with congestive heart failure
I Sjaastad et al.
ACTA PHYSIOLOGICA SCANDINAVICA (2003)
The alpha(1B)-adrenergic receptor decreases the inotropic response in the mouse Langendorff heart model
SA Ross et al.
CARDIOVASCULAR RESEARCH (2003)
Vasodilating beta-adrenoceptor blockers as cardiovascular therapeutics
N Toda
PHARMACOLOGY & THERAPEUTICS (2003)
Characteristic effects of alpha 1-beta 1,2-adrenergic blocking agent, carvedilol, on [Ca2+](i) in ventricular myocytes compared with those of timolol and atenolol
A Yao et al.
CIRCULATION JOURNAL (2003)
Dysfunction of mitochondrial respiratory chain complex I in human failing myocardium is not due to disturbed mitochondrial gene expression
RJ Scheubel et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2002)
Effect of selective and nonselective β-blockers on resting energy production rate and total body substrate utilization in chronic heart failure
M Podbregar et al.
JOURNAL OF CARDIAC FAILURE (2002)
Feedback inhibition of catecholamine release by two different α2-adrenoceptor subtypes prevents progression of heart failure
M Brede et al.
CIRCULATION (2002)
Absolute concentrations of high-energy phosphate metabolites in normal, hypertrophied, and failing human myocardium measured noninvasively with 31P-SLOOP magnetic resonance spectroscopy
M Beer et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2002)
Characterization of the β-adrenoceptor subtype involved in mediation of glucose transport in L6 cells
J Nevzorova et al.
BRITISH JOURNAL OF PHARMACOLOGY (2002)
Impaired myocardial fatty acid oxidation and reduced protein expression of retinoid X receptor-α in pacing-induced heart failure
JC Osorio et al.
CIRCULATION (2002)
Altered myocardial fatty acid and glucose metabolism in idiopathic dilated cardiomyopathy
VG Dávila-Román et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2002)
Knockout of the α1A/C-adrenergic receptor subtype:: The α1A/C is expressed in resistance arteries and is required to maintain arterial blood pressure
DG Rokosh et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Effect of carvedilol on microcirculatory and glucose metabolic regulation in patients with congestive heart failure secondary to ischemic cardiomyopathy
M Bottcher et al.
AMERICAN JOURNAL OF CARDIOLOGY (2002)
In vivo response to α1-adrenoreceptor stimulation in human white adipose tissue
M Boschmann et al.
OBESITY RESEARCH (2002)
In vivo α1-adrenergic lipolytic activity in subcutaneous adipose tissue of obese subjects
M Flechtner-Mors et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2002)
High levels of fatty acids delay the recovery of intracellular pH and cardiac efficiency in post-ischemic hearts by inhibiting glucose oxidation
Q Liu et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2002)
Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase
Y Minokoshi et al.
NATURE (2002)
Allosteric binding sites on cell-surface receptors: Novel targets for drug discovery
A Christopoulos
NATURE REVIEWS DRUG DISCOVERY (2002)
Metabolic gene expression in fetal and failing human heart
P Razeghi et al.
CIRCULATION (2001)
Heart failure with preserved systolic function - A different natural history?
M Senni et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2001)
Upregulation of functional β3-adrenergic receptor in the failing canine myocardium
HJ Cheng et al.
CIRCULATION RESEARCH (2001)
Inotropic therapy for heart failure: An evidence-based approach
GM Felker et al.
AMERICAN HEART JOURNAL (2001)
Targeted α1A-adrenergic receptor overexpression induces enhanced cardiac contractility but not hypertrophy
G Lin et al.
CIRCULATION RESEARCH (2001)
Cardiac-directed overexpression of wild-type α1B-adrenergic receptor induces dilated cardiomyopathy
I Lemire et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2001)
Regulation of myocardial βARK1 expression in catecholamine-induced cardiac hypertrophy in transgenic mice overexpressing α1B-adrenergic receptors
G Iaccarino et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2001)
Results from post-hoc analyses of the CIBIS II trial: effect of bisoprolol in high-risk patient groups with chronic heart failure
E Erdmann et al.
EUROPEAN JOURNAL OF HEART FAILURE (2001)
β1-adrenoceptor antibodies induce positive inotropic response in isolated cardiomyocytes
A Staudt et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2001)
Phe-308 and Phe-312 in transmembrane domain 7 are major sites of α1-adrenergic receptor antagonist binding -: Imidazoline agonists bind like antagonists
DJJ Waugh et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Comparative effects of carvedilol and metoprolol on left ventricular election fraction in heart failure: Results of a meta-analysis
M Packer et al.
AMERICAN HEART JOURNAL (2001)
Stimulatory effect of isoferulic acid on α1A-adrenoceptor to increase glucose uptake into cultured myoblast C2C12 cell of mice
IM Liu et al.
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL (2001)
Hypotension, autonomic failure, and cardiac hypertrophy in transgenic mice overexpressing the α1B-adrenergic receptor
MJ Zuscik et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Upregulation of β2-adrenoceptors and altered contractile response to inotropic amines in human failing myocardium
S Moniotte et al.
CIRCULATION (2001)
Molecular enzymology of carnitine transfer and transport
RR Ramsay et al.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY (2001)
Dual modulation of cell survival and cell death by β2-adrenergic signaling in adult mouse cardiac myocytes
WZ Zhu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Antioxidant properties of carvedilol and metoprolol in heart failure: A double-blind randomized controlled trial
M Arumanayagam et al.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2001)
The β2-adrenergic receptor delivers an antiapoptotic signal to cardiac myocytes through Gi-dependent coupling to phosphatidylinositol 3′-kinase
A Chesley et al.
CIRCULATION RESEARCH (2000)
Overexpression of the α1B-adrenergic receptor causes apoptotic neurodegeneration:: Multiple system atrophy
MJ Zuscik et al.
NATURE MEDICINE (2000)
Role of α1A-adrenoceptor in the regulation of glucose uptake into white adipocyte of rats in vitro
JT Cheng et al.
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL (2000)
The effects of β1-blockade on oxidative metabolism and the metabolic cost of ventricular work in patients with left ventricular dysfunction -: A double-blind, placebo-controlled, positron-emission tomography study
RSB Beanlands et al.
CIRCULATION (2000)
Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia
AS Marsin et al.
CURRENT BIOLOGY (2000)
AMP-activated protein kinase is activated by the stimulations of Gq-coupled receptors
K Kishi et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2000)
Mitochondrial free radical generation, oxidative stress, and aging
E Cadenas et al.
FREE RADICAL BIOLOGY AND MEDICINE (2000)
PPAR signaling in the control of cardiac energy metabolism
PM Barger et al.
TRENDS IN CARDIOVASCULAR MEDICINE (2000)
A comparison of carvedilol and metoprolol antioxidant activities in vitro
PG Lysko et al.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2000)
First clinical trial with etomoxir in patients with chronic congestive heart failure
S Schmidt-Schweda et al.
CLINICAL SCIENCE (2000)
Roles of mitogen-activated protein kinases and protein kinase C in α1A-adrenoceptor-mediated stimulation of the sarcolemmal Na+-H+ exchanger
AK Snabaitis et al.
CIRCULATION RESEARCH (2000)
Mitochondrial function in heart muscle from patients with idiopathic dilated cardiomyopathy
D Jarreta et al.
CARDIOVASCULAR RESEARCH (2000)
Mitochondrial respiratory chain activity in idiopathic dilated cardiomyopathy
AF Quigley et al.
JOURNAL OF CARDIAC FAILURE (2000)
beta(3)-adrenoceptor deficiency blocks nitric oxide-dependent inhibition of myocardial contractility
P Varghese et al.
JOURNAL OF CLINICAL INVESTIGATION (2000)
Adverse effects of constitutively active alpha(1B)-adrenergic receptors after pressure overload in mouse hearts
BH Wang et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2000)
Treatment of heart failure with beta-blockers. Mechanisms and results
M Bohm et al.
BASIC RESEARCH IN CARDIOLOGY (2000)
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