期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 22, 期 15, 页码 -出版社
MDPI
DOI: 10.3390/ijms22157837
关键词
musculoskeletal tissue; tissue engineering; 3D bioprinting; decellularized extracellular matrix bioink
资金
- National Research Foundation of Korea [2019R1A3A3005437, 2020M3H4A1A02084827]
- Beijing Institute of Technology Research Fund Program for Young Scholars [XSQD-202123003]
- National Research Foundation of Korea [2019R1A3A3005437, 2020M3H4A1A02084827] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
This review discusses the advances in musculoskeletal tissue engineering using 3D bioprinting technology and decellularized extracellular matrix bioink. It focuses on in vivo regeneration and in vitro modeling of musculoskeletal tissue, while also addressing current breakthroughs, limitations, and future prospects.
The musculoskeletal system is a vital body system that protects internal organs, supports locomotion, and maintains homeostatic function. Unfortunately, musculoskeletal disorders are the leading cause of disability worldwide. Although implant surgeries using autografts, allografts, and xenografts have been conducted, several adverse effects, including donor site morbidity and immunoreaction, exist. To overcome these limitations, various biomedical engineering approaches have been proposed based on an understanding of the complexity of human musculoskeletal tissue. In this review, the leading edge of musculoskeletal tissue engineering using 3D bioprinting technology and musculoskeletal tissue-derived decellularized extracellular matrix bioink is described. In particular, studies on in vivo regeneration and in vitro modeling of musculoskeletal tissue have been focused on. Lastly, the current breakthroughs, limitations, and future perspectives are described.
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