4.7 Article

HBsAg Dampened STING Associated Activation of NK Cells in HBeAg-Negative CHB Patients

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Pharmacology & Pharmacy

Detection of Viral Infections by Innate Immunity

Michael Carty et al.

Summary: Pattern recognition receptors (PRRs) and inflammasomes play key roles in the anti-viral innate immune system by detecting viral molecular patterns and producing inflammatory cytokines to combat viral infections. Inflammasomes contribute to anti-viral responses by inducing cell death. Excessive innate immune responses may contribute to viral pathology.

BIOCHEMICAL PHARMACOLOGY (2021)

Review Immunology

Regulation of RIG-I-like receptor-mediated signaling: interaction between host and viral factors

Koji Onomoto et al.

Summary: RLRs are RNA sensor molecules that play essential roles in innate antiviral immunity by inducing downstream signaling via interactions with various host and viral factors. The signaling mediated by RLRs is regulated by interactions with endogenous RNAs and host proteins, and deregulation can lead to autoimmune and autoinflammatory disorders.

CELLULAR & MOLECULAR IMMUNOLOGY (2021)

Article Immunology

AdrA as a Potential Immunomodulatory Candidate for STING-Mediated Antiviral Therapy That Required Both Type I IFN and TNF-α Production

Estefania Rodriguez-Garcia et al.

Summary: Several bacterial diguanylate cyclases, particularly AdrA from Salmonella Enteritidis, have been identified as potent inducers of a STING-mediated IFN response. Using mouse models, it was shown that AdrA can reduce viremia in hepatitis B virus-transgenic and adenovirus-associated virus-HBV mice. The antiviral activity of AdrA relies on the presence of STING, type I IFN, and TNF-alpha, which act synergistically in combating viral infections.

JOURNAL OF IMMUNOLOGY (2021)

Article Immunology

Manganese Breaks the Immune Tolerance of HBs-Ag

Mengxin Lin et al.

Summary: Manganese (Mn2+) has been shown to promote IFN-alpha and IFN-beta production and activate TBK1 and IRF3, potentially serving as an adjuvant for HBV vaccination. In HBV infection and vaccination, Mn2+ can enhance type I interferon production and immune cell function.

OPEN FORUM INFECTIOUS DISEASES (2021)

Review Immunology

Toll-Like Receptors in Natural Killer Cells and Their Application for Immunotherapy

Ji-Yoon Noh et al.

JOURNAL OF IMMUNOLOGY RESEARCH (2020)

Article Immunology

NK cells mediate clearance of CD8(+) T cell-resistant tumors in response to STING agonists

Christopher J. Nicolai et al.

SCIENCE IMMUNOLOGY (2020)

Article Multidisciplinary Sciences

Interferon-independent STING signaling promotes resistance to HSV-1 in vivo

Livia H. Yamashiro et al.

NATURE COMMUNICATIONS (2020)

Review Medicine, General & Internal

New Approaches to the Treatment of Chronic Hepatitis B

Alexandra Alexopoulou et al.

JOURNAL OF CLINICAL MEDICINE (2020)

Article Biochemistry & Molecular Biology

STING signaling remodels the tumor microenvironment by antagonizing myeloid-derived suppressor cell expansion

Chuan-xia Zhang et al.

CELL DEATH AND DIFFERENTIATION (2019)

Article Cell Biology

STAT3 directly regulates NKp46 transcription in NK cells of HBeAg-negative CHB patients

Bingqing Zheng et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2019)

Article Medicine, General & Internal

Hepatitis B virus infection

Man-Fung Yuen et al.

NATURE REVIEWS DISEASE PRIMERS (2018)

Article Immunology

Exosomes mediate hepatitis B virus (HBV) transmission and NK-cell dysfunction

Yinli Yang et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2017)

Article Immunology

miR-146a negatively regulates NK cell functions via STAT1 signaling

Dongqing Xu et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2017)

Article Oncology

Activation of STING-Dependent Innate Immune Signaling By S-Phase-Specific DNA Damage in Breast Cancer

Eileen E. Parkes et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2017)

Article Oncology

Activation of STING-Dependent Innate Immune Signaling By S-Phase-Specific DNA Damage in Breast Cancer

Eileen E. Parkes et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2017)

Review Immunology

Crosstalk between Cytoplasmic RIG-I and STING Sensing Pathways

Alessandra Zevini et al.

TRENDS IN IMMUNOLOGY (2017)

Review Microbiology

Innate immune evasion strategies of DNA and RNA viruses

Dia C. Beachboard et al.

CURRENT OPINION IN MICROBIOLOGY (2016)

Article Gastroenterology & Hepatology

Lack of immunological DNA sensing in hepatocytes facilitates hepatitis B virus infection

Martin K. Thomsen et al.

HEPATOLOGY (2016)

Article Immunology

Hepatitis B virus antigens impair NK cell function

Yinli Yang et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2016)

Article Medicine, General & Internal

Hepatitis B virus infection

Christian Trepo et al.

LANCET (2014)

Editorial Material Oncology

STING-dependent cytosolic DNA sensor pathways regulate NKG2D ligand expression

Nina Le Bert et al.

ONCOIMMUNOLOGY (2014)