4.7 Review

Alternate Roles of Sox Transcription Factors beyond Transcription Initiation

期刊

出版社

MDPI
DOI: 10.3390/ijms22115949

关键词

Sox proteins; transcription factor; transcription; co-transcriptional splicing; translational control

资金

  1. Science and Technology Project of Shenzhen [JCYJ20190807160411245]
  2. Fundamental Research Funds for the Central Universities, Sun Yat-sen University [2021qntd43]

向作者/读者索取更多资源

Sox proteins, known as crucial transcription factors, are not limited to transcription initiation but also involved in regulating alternative splicing networks and translational control.
Sox proteins are known as crucial transcription factors for many developmental processes and for a wide range of common diseases. They were believed to specifically bind and bend DNA with other transcription factors and elicit transcriptional activation or repression activities in the early stage of transcription. However, their functions are not limited to transcription initiation. It has been showed that Sox proteins are involved in the regulation of alternative splicing regulatory networks and translational control. In this review, we discuss the current knowledge on how Sox transcription factors such as Sox2, Sry, Sox6, and Sox9 allow the coordination of co-transcriptional splicing and also the mechanism of SOX4-mediated translational control in the context of RNA polymerase III.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据