4.7 Review

Mesenchymal Stem Cells Therapies on Fibrotic Heart Diseases

期刊

出版社

MDPI
DOI: 10.3390/ijms22147447

关键词

mesenchymal stem cells; cardiac fibrosis; cardiovascular diseases

资金

  1. Departamento de Ciencia e Tecnologia (DECIT/MS) do Ministerio da Saude
  2. Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
  3. Instituto Nacional de Ciencia e Tecnologia em Medicina Regenerativa
  4. Fundacao de Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ)

向作者/读者索取更多资源

Stem cell therapy shows promising potential as an alternative approach to treat heart diseases, with multipotent stem cells sourced from bone marrow, adipose tissue, umbilical cord, and placenta commonly used in clinical trials. Therapeutic use of these cells aims to reduce cardiac fibrosis and inflammation, preventing abnormal cardiac remodeling and dysfunction.
Stem cell therapy is a promising alternative approach to heart diseases. The most prevalent source of multipotent stem cells, usually called somatic or adult stem cells (mesenchymal stromal/stem cells, MSCs) used in clinical trials is bone marrow (BM-MSCs), adipose tissue (AT-MSCs), umbilical cord (UC-MSCs) and placenta. Therapeutic use of MSCs in cardiovascular diseases is based on the benefits in reducing cardiac fibrosis and inflammation that compose the cardiac remodeling responsible for the maintenance of normal function, something which may end up causing progressive and irreversible dysfunction. Many factors lead to cardiac fibrosis and failure, and an effective therapy is lacking to reverse or attenuate this condition. Different approaches have been shown to be promising in surpassing the poor survival of transplanted cells in cardiac tissue to provide cardioprotection and prevent cardiac remodeling. This review includes the description of pre-clinical and clinical investigation of the therapeutic potential of MSCs in improving ventricular dysfunction consequent to diverse cardiac diseases.

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