期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 22, 期 18, 页码 -出版社
MDPI
DOI: 10.3390/ijms22189823
关键词
blood pressure; potassium alginate oligosaccharides; gut microbiota; heart failure
资金
- National Natural Science Foundation of China [31872893]
- Key Research and Development Project Foundation of Shandong Province [2017YYSP003]
- Shandong Natural Science Fund [ZR2017MD006]
Food-derived oligosaccharides, specifically potassium alginate oligosaccharides (PAO), have shown promising therapeutic potential in lowering blood pressure by altering the gut microbiota composition and increasing microbial diversity. This study found that PAO administration led to significant decreases in systolic blood pressure and mean arterial pressure, as well as protective effects in preventing heart failure by down-regulating certain genes and reducing the concentrations of certain peptides in plasma. Additionally, PAO was observed to decrease the Firmicutes to Bacteroidetes ratio in the gut microbiota, suggesting a potential mechanism for its cardiovascular protective effects.
Food-derived oligosaccharides show promising therapeutic potential in lowering blood pressure (BP), but the mechanism is poorly understood. Recently, the potential role of gut microbiota (GM) in hypertension has been investigated, but the specific GM signature that may participate in hypertension remains unclear. To test the potassium alginate oligosaccharides (PAO) mechanism in lowering BP and specific microbial signature changes in altering GM, we administered various dosages of PAO in 40 spontaneously hypertensive rats for a duration of six weeks. We analyzed BP, sequenced the 16S ribosomal DNA gene in the cecum content, and gathered RNA-seq data in cardiac tissues. We showed that the oral administration of PAO could significantly decrease systolic BP and mean arterial pressure. Transcriptome analyses demonstrated that the protective effects of developing heart failure were accompanied by down-regulating of the Natriuretic Peptide A gene expression and by decreasing the concentrations of angiotensin II and atrial natriuretic peptide in plasma. In comparison to the Vehicle control, PAO could increase the microbial diversity by altering the composition of GM. PAO could also decrease the ratio of Firmicutes to Bacteroidetes by decreasing the abundance of Prevotella and Phascolarctobacterium bacteria. The favorable effect of PAO may be added to the positive influence of the abundance of major metabolites produced by Gram-negative bacteria in GM. We suggest that PAO caused changes in GM, and thus, they played an important role in preventing the development of cardiovascular disease.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据