期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 22, 期 15, 页码 -出版社
MDPI
DOI: 10.3390/ijms22158113
关键词
breast cancer; breast cancer stem cells; epigenetic regulation; therapies
资金
- Ministry of Science and Technology [MOST 106-2314-B-442-001-MY3, MOST 109-2314-B-442-001, MOST 109-2314-B-075B-002]
- National Health Research Institutes [NHRI-109BCCO-MF-202015-01]
- Show Chwan Memorial Hospital, Taiwan [SRD-109023, SRD-109035, RD107063]
Breast cancer remains the most commonly diagnosed cancer and the leading cause of cancer death among women globally. Breast cancer stem cells (BCSCs) play essential roles in the progression, recurrence, metastasis, chemoresistance, and treatments of breast cancer. Aberrant epigenetic regulation is involved in carcinogenesis, therapeutic resistance, and metastasis of BCSCs, and therapies targeting these biomarkers are being developed.
Globally, breast cancer has remained the most commonly diagnosed cancer and the leading cause of cancer death among women. Breast cancer is a highly heterogeneous and phenotypically diverse group of diseases, which require different selection of treatments. Breast cancer stem cells (BCSCs), a small subset of cancer cells with stem cell-like properties, play essential roles in breast cancer progression, recurrence, metastasis, chemoresistance and treatments. Epigenetics is defined as inheritable changes in gene expression without alteration in DNA sequence. Epigenetic regulation includes DNA methylation and demethylation, as well as histone modifications. Aberrant epigenetic regulation results in carcinogenesis. In this review, the mechanism of epigenetic regulation involved in carcinogenesis, therapeutic resistance and metastasis of BCSCs will be discussed, and finally, the therapies targeting these biomarkers will be presented.
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