期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 22, 期 11, 页码 -出版社
MDPI
DOI: 10.3390/ijms22116027
关键词
long noncoding RNAs; microRNAs in kidney; kidney fibrosis; EMT; EndMT; diabetes mellitus; diabetic kidney disease
资金
- Kanazawa Medical University [C2011-4, C2012-1]
- National Institutes of Health [R01HL131952]
- Grant for Promoted Research [S2015-3, S2016-3, S2017-1]
Long noncoding RNAs (lncRNAs) play central roles in diabetes and cancer, regulating diverse targets and interacting with microRNAs bidirectionally. Their potential as therapeutic targets is promising, emphasizing their significance in the pathogenesis of diabetes and diabetic kidney disease.
Large-scale RNA sequencing and genome-wide profiling data revealed the identification of a heterogeneous group of noncoding RNAs, known as long noncoding RNAs (lncRNAs). These lncRNAs play central roles in health and disease processes in diabetes and cancer. The critical association between aberrant expression of lncRNAs in diabetes and diabetic kidney disease have been reported. LncRNAs regulate diverse targets and can function as sponges for regulatory microRNAs, which influence disease phenotype in the kidneys. Importantly, lncRNAs and microRNAs may regulate bidirectional or crosstalk mechanisms, which need to be further investigated. These studies offer the novel possibility that lncRNAs may be used as potential therapeutic targets for diabetes and diabetic kidney diseases. Here, we discuss the functions and mechanisms of actions of lncRNAs, and their crosstalk interactions with microRNAs, which provide insight and promise as therapeutic targets, emphasizing their role in the pathogenesis of diabetes and diabetic kidney disease
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据