期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 22, 期 13, 页码 -出版社
MDPI
DOI: 10.3390/ijms22137154
关键词
next-generation sequencing; multi-gene testing; gene panels; breast cancer; metastatic triple-negative breast cancer; tumor mutational burden
资金
- Italian Association for Cancer Research (AIRC) Investigator Grant [IG 21761]
- Assocazione Italiana contro le leucemie (AIL)
This review discusses the clinical applications of multi-gene testing in breast cancer, especially in metastatic triple-negative breast cancer (mTNBC), and briefly touches on the emerging role of immunotherapy in mTNBC. The potential predictive utility of homologous recombination repair deficiency (HRD) and tumor mutational burden (TMB) in mTNBC treatment is also highlighted, with the use of NGS platforms in clinical practice.
Next-generation sequencing (NGS) is the technology of choice for the routine screening of tumor samples in clinical practice. In this setting, the targeted sequencing of a restricted number of clinically relevant genes represents the most practical option when looking for genetic variants associated with cancer, as well as for the choice of targeted treatments. In this review, we analyze available NGS platforms and clinical applications of multi-gene testing in breast cancer, with a focus on metastatic triple-negative breast cancer (mTNBC). We make an overview of the clinical utility of multi-gene testing in mTNBC, and then, as immunotherapy is emerging as a possible targeted therapy for mTNBC, we also briefly report on the results of the latest clinical trials involving immune checkpoint inhibitors (ICIs) and TNBC, where NGS could play a role for the potential predictive utility of homologous recombination repair deficiency (HRD) and tumor mutational burden (TMB).
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据