相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。4-Aryl-1-oxa-4,9-diazaspiro[5.5]undecane Derivatives as Dual μ-Opioid Receptor Agonists and σ1 Receptor Antagonists for the Treatment of Pain
Monica Garcia et al.
JOURNAL OF MEDICINAL CHEMISTRY (2020)
The Sigma-1 Receptor at the Crossroad of Proteostasis, Neurodegeneration, and Autophagy
Maximilian G. Christ et al.
TRENDS IN NEUROSCIENCES (2020)
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
David E. Gordon et al.
NATURE (2020)
Cannabinoid Receptor Subtype 2 (CB2R) in a Multitarget Approach: Perspective of an Innovative Strategy in Cancer and Neurodegeneration
Giuseppe Felice Mangiatordi et al.
JOURNAL OF MEDICINAL CHEMISTRY (2020)
Discovery of EST73502, a Dual μ-Opioid Receptor Agonist and σ1 Receptor Antagonist Clinical Candidate for the Treatment of Pain
Monica Garcia et al.
JOURNAL OF MEDICINAL CHEMISTRY (2020)
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms
David E. Gordon et al.
SCIENCE (2020)
PB28, the Sigma-1 and Sigma-2 Receptors Modulator With Potent Anti-SARS-CoV-2 Activity: A Review About Its Pharmacological Properties and Structure Affinity Relationships
Carmen Abate et al.
FRONTIERS IN PHARMACOLOGY (2020)
Repurposing Sigma-1 Receptor Ligands for COVID-19 Therapy?
Jose Miguel Vela
FRONTIERS IN PHARMACOLOGY (2020)
New flavonoid - N,N-dibenzyl(N-methyl)amine hybrids: Multi-target-directed agents for Alzheimer′s disease endowed with neurogenic properties
Martin Estrada-Valencia et al.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2019)
Pridopidine Induces Functional Neurorestoration Via the Sigma-1 Receptor in a Mouse Model of Parkinson's Disease
Veronica Francardo et al.
NEUROTHERAPEUTICS (2019)
Sigma-2 receptor/TMEM97 agonist PB221 as an alternative drug for brain tumor
Chia-Chi Liu et al.
BMC CANCER (2019)
Pridopidine stabilizes mushroom spines in mouse models of Alzheimer's disease by acting on the sigma-1 receptor
Daniel Ryskamp et al.
NEUROBIOLOGY OF DISEASE (2019)
Activation of Sigma Receptors With Afobazole Modulates Microglial, but Not Neuronal, Apoptotic Gene Expression in Response to Long-Term Ischemia Exposure
Adam A. Behensky et al.
FRONTIERS IN NEUROSCIENCE (2019)
The Molecular Function of σ Receptors: Past, Present, and Future
Hayden R. Schmidt et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2019)
High-affinity sigma-1 (σ1) receptor ligands based on the σ1 antagonist PB212
Mauro Niso et al.
FUTURE MEDICINAL CHEMISTRY (2019)
Chaperone Sigma1R mediates the neuroprotective action of afobazole in the 6-OHDA model of Parkinson's disease
Mikhail V. Voronin et al.
SCIENTIFIC REPORTS (2019)
Novel multitarget-directed ligands targeting acetylcholinesterase and σ1 receptors as lead compounds for treatment of Alzheimer's disease: Synthesis, evaluation, and structural characterization of their complexes with acetylcholinesterase
Julien Lalut et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)
Pridopidine, a clinic-ready compound, reduces 3,4-dihydroxyphenylalanine-induced dyskinesia in Parkinsonian macaques
Tom H. Johnston et al.
MOVEMENT DISORDERS (2019)
Efficacy of a Novel Sigma-1 Receptor Antagonist for Oxaliplatin-Induced Neuropathy: A Randomized, Double-Blind, Placebo-Controlled Phase IIa Clinical Trial
Jordi Bruna et al.
NEUROTHERAPEUTICS (2018)
AF710B, an M1/sigma-1 receptor agonist with long-lasting disease-modifying properties in a transgenic rat model of Alzheimer's disease
Helene Hall et al.
ALZHEIMERS & DEMENTIA (2018)
Neurogenic and neuroprotective donepezil-flavonoid hybrids with sigma-1 affinity and inhibition of key enzymes in Alzheimer's disease
Martin Estrada Valencia et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)
Multifunctional thiosemicarbazones and deconstructed analogues as a strategy to study the involvement of metal chelation, Sigma-2 (σ2) receptor and P-gp protein in the cytotoxic action: In vitro and in vivo activity in pancreatic tumors
Maria Laura Pati et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)
Pharmacological profiling of sigma 1 receptor ligands by novel receptor homomer assays
Hideaki Yano et al.
NEUROPHARMACOLOGY (2018)
Structural basis for σ1 receptor ligand recognition
Hayden R. Schmidt et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2018)
Radiosynthesis and First-In-Human PET/MRI Evaluation with Clinical-Grade [18F]FTC-146
Bin Shen et al.
MOLECULAR IMAGING AND BIOLOGY (2017)
The sigma(1) receptor agonist (+)-pentazocine increases store-operated Ca2+ entry in MCF7(sigma 1 )and SK-N-SH cell lines
Giuseppe Gasparre et al.
PHARMACOLOGICAL REPORTS (2017)
The sigma-1 receptor modulates methamphetamine dysregulation of dopamine neurotransmission
Danielle O. Sambo et al.
NATURE COMMUNICATIONS (2017)
Roles of sigma-1 receptors on mitochondrial functions relevant to neurodegenerative diseases
Tzu-Yu Weng et al.
JOURNAL OF BIOMEDICAL SCIENCE (2017)
Sigma-2 receptor agonist derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) induce cell death via mitochondrial superoxide production and caspase activation in pancreatic cancer
Maria Laura Pati et al.
BMC CANCER (2017)
AF710B, a Novell M1/sigma 1 Agonist With Therapeutic Efficacy on Animal Models of Alzheimer's Disease
Abraham Fisher et al.
NEURODEGENERATIVE DISEASES (2016)
Protection by sigma-1 receptor agonists is synergic with donepezil, but not with memantine, in a mouse model of amyloid-induced memory impairments
Tangui Maurice
BEHAVIOURAL BRAIN RESEARCH (2016)
New neurogenic lipoic-based hybrids as innovative Alzheimer's drugs with σ-1 agonism and β-secretase inhibition
Martin Estrada et al.
FUTURE MEDICINAL CHEMISTRY (2016)
Crystal structure of the human σ1 receptor
Hayden R. Schmidt et al.
NATURE (2016)
The Sigma-1 Receptor as a Pluripotent Modulator in Living Systems
Tsung-Ping Su et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2016)
Contribution of Sigma-1 receptor to cytoprotective effect of afobazole
Mikhail V. Voronin et al.
PHARMACOLOGY RESEARCH & PERSPECTIVES (2016)
The sigma-1 receptors are present in monomeric and oligomeric forms in living cells in the presence and absence of ligands
Ashish K. Mishra et al.
BIOCHEMICAL JOURNAL (2015)
Cytoprotective Effect of Afobazole and Its Main Metabolite M-11
I. A. Kadnikov et al.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE (2015)
Haloperidol metabolite II prodrug: Asymmetric synthesis and biological evaluation on rat C6 glioma cells
Piera Sozio et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2015)
Novel Multitarget-Directed Ligands (MTDLs) with Acetylcholinesterase (AChE) Inhibitory and Serotonergic Subtype 4 Receptor (5-HT4R) Agonist Activities As Potential Agents against Alzheimer's Disease: The Design of Donecopride
Christophe Rochais et al.
JOURNAL OF MEDICINAL CHEMISTRY (2015)
Neuroprotective Effects of Cutamesine, a Ligand of the Sigma-1 Receptor Chaperone, Against Noise-Induced Hearing Loss
Daisuke Yamashita et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2015)
Live imaging reveals a new role for the sigma-1 (σ1) receptor in allowing microglia to leave brain injuries
Christian Moritz et al.
NEUROSCIENCE LETTERS (2015)
Pridopidine selectively occupies sigma-1 rather than dopamine D2 receptors at behaviorally active doses
Kristoffer Sahlholm et al.
PSYCHOPHARMACOLOGY (2015)
Novel metal chelators thiosemicarbazones with activity at the σ2 receptors and P-glycoprotein: an innovative strategy for resistant tumor treatment
Maria Laura Pati et al.
RSC ADVANCES (2015)
Multifunctional compounds: Smart molecules for multifactorial diseases
Yogita Bansal et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2014)
Lipoic Acid and Dihydrolipoic Acid. A Comprehensive Theoretical Study of Their Antioxidant Activity Supported by Available Experimental Kinetic Data
Romina Castaneda-Arriaga et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2014)
Predicting the Antinociceptive Efficacy of σ1 Receptor Ligands by a Novel Receptor Fluorescence Resonance Energy Transfer (FRET) Based Biosensor
Maricel Gomez-Soler et al.
JOURNAL OF MEDICINAL CHEMISTRY (2014)
Cocaine Disrupts Histamine H3 Receptor Modulation of Dopamine D1 Receptor Signaling: σ1-D1-H3 Receptor Complexes as Key Targets for Reducing Cocaine's Effects
Estefania Moreno et al.
JOURNAL OF NEUROSCIENCE (2014)
Evaluation of sigma-1 Receptor Radioligand F-18-FTC-146 in Rats and Squirrel Monkeys Using PET
Michelle L. James et al.
JOURNAL OF NUCLEAR MEDICINE (2014)
Genetic inactivation and pharmacological blockade of sigma-1 receptors prevent paclitaxel-induced sensory-nerve mitochondrial abnormalities and neuropathic pain in mice
Francisco R. Nieto et al.
MOLECULAR PAIN (2014)
The effects of new sigma (σ) receptor ligands, PB190 and PB212, in the models predictive of antidepressant activity
Grazyna Skuza et al.
PHARMACOLOGICAL REPORTS (2014)
CDK5 activator protein p25 preferentially binds and activates GSK3β
Hei-Man Chow et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Dose-dependent sigma-1 receptor occupancy by donepezil in rat brain can be assessed with 11C-SA4503 and microPET
Nisha K. Ramakrishnan et al.
PSYCHOPHARMACOLOGY (2014)
Cardioprotective Effect of the Selective Sigma-1 Receptor Agonist, SA4503
Kohga Hirano et al.
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN (2014)
Safety, tolerability and pharmacokinetics of single and multiple doses of a novel sigma-1 receptor antagonist in three randomized phase I studies
Montserrat Abadias et al.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2013)
Sigma-2 Receptor Agonists as Possible Antitumor Agents in Resistant Tumors: Hints for Collateral Sensitivity
Mauro Niso et al.
CHEMMEDCHEM (2013)
Rationally Designed Multi-Targeted Agents Against Neurodegenerative Diseases
W. J. Geldenhuys et al.
CURRENT MEDICINAL CHEMISTRY (2013)
Sigma-1 receptor antagonism as opioid adjuvant strategy: Enhancement of opioid antinociception without increasing adverse effects
Alba Vidal-Torres et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2013)
The dopamine stabilizers ACR16 and (-)-OSU6162 display nanomolar affinities at the sigma-1 receptor
K. Sahlholm et al.
MOLECULAR PSYCHIATRY (2013)
Blockade of Tau Hyperphosphorylation and Aβ1-42 Generation by the Aminotetrahydrofuran Derivative ANAVEX2-73, a Mixed Muscarinic and σ1 Receptor Agonist, in a Nontransgenic Mouse Model of Alzheimer's Disease
Valentine Lahmy et al.
NEUROPSYCHOPHARMACOLOGY (2013)
Cocaine Inhibits Dopamine D2 Receptor Signaling via Sigma-1-D2 Receptor Heteromers
Gemma Navarro et al.
PLOS ONE (2013)
Sigma-1 Receptor Chaperone at the ER-Mitochondrion Interface Mediates the Mitochondrion-ER-Nucleus Signaling for Cellular Survival
Tomohisa Mori et al.
PLOS ONE (2013)
Potential Role of the Sigma-1 Receptor Chaperone in the Beneficial Effects of Donepezil in Dementia with Lewy Bodies
Kenji Hashimoto
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE (2013)
Stimulation of Sigma Receptors with Afobazole Blocks Activation of Microglia and Reduces Toxicity Caused by Amyloid-β25-35
Adam A. Behensky et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2013)
Pharmacological properties of S1RA, a new sigma-1 receptor antagonist that inhibits neuropathic pain and activity-induced spinal sensitization
L. Romero et al.
BRITISH JOURNAL OF PHARMACOLOGY (2012)
New Positron Emission Tomography (PET) Radioligand for Imaging σ-1 Receptors in Living Subjects
Michelle L. James et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Role of Sigma-1 Receptors in Paclitaxel-Induced Neuropathic Pain in Mice
Francisco Rafael Nieto et al.
JOURNAL OF PAIN (2012)
New Adamantane Derivatives with Sigma Affinity and Antiproliferative Activity
Stefanos Riganas et al.
MEDICINAL CHEMISTRY (2012)
Association between a variant of the sigma-1 receptor gene and Alzheimer's disease
Agnes Feher et al.
NEUROSCIENCE LETTERS (2012)
Loss of Muscarinic M1 Receptor Exacerbates Alzheimer's Disease-Like Pathology and Cognitive Decline
Rodrigo Medeiros et al.
AMERICAN JOURNAL OF PATHOLOGY (2011)
Antagonist action of progesterone at σ-receptors in the modulation of voltage-gated sodium channels
Molly Johannessen et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2011)
Sigma Receptor Agonists: Receptor Binding and Effects on Mesolimbic Dopamine Neurotransmission Assessed by Microdialysis
Linda Garces-Ramirez et al.
BIOLOGICAL PSYCHIATRY (2011)
Genetic Polymorphisms in Sigma-1 Receptor and Apolipoprotein E Interact to Influence the Severity of Alzheimer's Disease
Yue Huang et al.
CURRENT ALZHEIMER RESEARCH (2011)
Antiproliferative activity of phenylbutyrate ester of haloperidol metabolite II [(+/-)-MRJF4] in prostate cancer cells
Agostino Marrazzo et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2011)
Arylamides hybrids of two high-affinity σ2 receptor ligands as tools for the development of PET radiotracers
Carmen Abate et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2011)
Analogues of σ Receptor Ligand 1-Cyclohexyl-4[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with Added Polar Functionality and Reduced Lipophilicity for Potential Use as Positron Emission Tomography Radiotracers
Carmen Abate et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
Effects of PB190 and PB212, new σ receptor ligands, on glucocorticoid receptor-mediated gene transcription in LMCAT cells
Grazyna Skuza et al.
PHARMACOLOGICAL REPORTS (2011)
Dimethyl-Carbamic Acid 2,3-Bis-Dimethylcarbamoyloxy-6-(4-Ethyl-Piperazine-1-Carbonyl)-Phenyl Ester: A Novel Multi-Target Therapeutic Approach to Neuroprotection
Laurent Lecanu et al.
MEDICINAL CHEMISTRY (2010)
Exploring the Importance of Piperazine N-Atoms for σ2 Receptor Affinity and Activity in a Series of Analogs of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28)
Francesco Berardi et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
The Hallucinogen N,N-Dimethyltryptamine (DMT) Is an Endogenous Sigma-1 Receptor Regulator
Dominique Fontanilla et al.
SCIENCE (2009)
Low density of sigma1 receptors in early Alzheimer's disease
Masahiro Mishina et al.
ANNALS OF NUCLEAR MEDICINE (2008)
An Emerging Role for Voltage-Gated Na+ Channels in Cellular Migration: Regulation of Central Nervous System Development and Potentiation of Invasive Cancers
William J. Brackenbury et al.
NEUROSCIENTIST (2008)
Sigma-1 receptor chaperones at the ER-Mitochondrion interface regulate Ca2+ signaling and cell survival
Teruo Hayashi et al.
CELL (2007)
Involvement of the sigma1 (σ1) receptor in the anti-amnesic, but not antidepressant-like, effects of the aminotetrahydrofuran derivative ANAVEX1-41
J. Espallergues et al.
BRITISH JOURNAL OF PHARMACOLOGY (2007)
Irreversible blockade of sigma-1 receptors by haloperidol and its metabolites in guinea pig brain and SH-SY5Y human neuroblastoma cells
Enrique J. Cobos et al.
JOURNAL OF NEUROCHEMISTRY (2007)
How to design multi-target drugs: target search options in cellular networks
Tamas Korcsmaros et al.
EXPERT OPINION ON DRUG DISCOVERY (2007)
The sigma-1 receptor modulates NMDA receptor synaptic transmission and plasticity via SK channels in rat hippocampus
Marzia Martina et al.
JOURNAL OF PHYSIOLOGY-LONDON (2007)
The anti-amnesic and neuroprotective effects of donepezil against amyloid β25-35 peptide-induced toxicity in mice involve an interaction with the σ1 receptor
J. Meunier et al.
BRITISH JOURNAL OF PHARMACOLOGY (2006)
Interaction with σ1 protein, but not N-methyl-D-aspartate receptor, is involved in the pharmacological activity of donepezil
T Maurice et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2006)
σ1 and σ2 receptor binding affinity and selectivity of SA4503 and fluoroethyl SA4503
JR Lever et al.
SYNAPSE (2006)
M1 receptors play a central role in modulating AD-like pathology in transgenic mice
A Caccamo et al.
NEURON (2006)
NGP1-01 is a brain-permeable dual blocker of neuronal voltage- and ligand-operated calcium channels
Cornelia Kiewert et al.
NEUROCHEMICAL RESEARCH (2006)
Human neoplastic mesothelial cells express voltage-gated sodium channels involved in cell motility
Gianluca Fulgenzi et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2006)
Methyl substitution on the piperidine ring of N-[ω-(6-methoxynaphthalen-1-yl)alkyl] derivatives as a probe for selective binding and activity at the σ1 receptor
F Berardi et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
Designed multiple ligands. An emerging drug discovery paradigm
R Morphy et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
Pharmacophore identification for sigma-1 (σ1) receptor binding:: Application of the deconstruction reconstruction elaboration approach
RA Glennon
MINI-REVIEWS IN MEDICINAL CHEMISTRY (2005)
Discovery of high-affinity ligands of σ1 receptor, ERG2, and emopamil binding protein by pharmacophore modeling and virtual screening
C Laggner et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
Pharmacology and structure-activity relationships of bioactive polycyclic cage compounds: A focus on pentacycloundecane derivatives
WJ Geldenhuys et al.
MEDICINAL RESEARCH REVIEWS (2005)
4-(tetralin-1-yl)- and 4-(naphthalen-1-yl)alkyl derivatives of 1-cyclohexylpiperazine as σ receptor ligands with agonist σ2 activity
F Berardi et al.
JOURNAL OF MEDICINAL CHEMISTRY (2004)
Involvement of the sigma1 receptor in the modulation of dopaminergic transmission by amantadine
M Peeters et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2004)
Sigma receptors: biology and therapeutic potential
X Guitart et al.
PSYCHOPHARMACOLOGY (2004)
A new method for evaluating σ2 ligand activity in the isolated guinea-pig bladder
NA Colabufo et al.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2003)
A potential antidepressant activity of SA4503, a selective σ1 receptor agonist
G Skuza et al.
BEHAVIOURAL PHARMACOLOGY (2002)
Sigma1 (σ1) receptor antagonists represent a new strategy against cocaine addiction and toxicity
T Maurice et al.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2002)
Beneficial effect of the σ1 receptor agonist PRE-084 against the spatial learning deficits in aged rats
T Maurice
EUROPEAN JOURNAL OF PHARMACOLOGY (2001)
Conformationally restricted analogs of BD1008 and an antisense oligodeoxynucleotide targeting σ1 receptors produce anti-cocaine effects in mice
RR Matsumoto et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2001)
Correlation between neuroleptic binding to σ1 and σ2 receptors and acute dystonic reactions
RR Matsumoto et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2000)
A sigma-1 receptor selective analogue of BD1008. A potential substitute for (+)-opioids in sigma receptor binding assays
DY Maeda et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2000)
Immunocytochemical localization of the sigma(1) receptor in the adult rat central nervous system
G Alonso et al.
NEUROSCIENCE (2000)