4.7 Review

Glutathione and Related Molecules in Parkinsonism

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Clinical Neurology

Ageing promotes pathological alpha-synuclein propagation and autonomic dysfunction in wild-type rats

Nathalie Van den Berge et al.

Summary: Using a rat model, it was found that the propagation of alpha-synuclein pathology from the gut to the brain is more efficient in old rats, resulting in dysfunction of the heart and stomach similar to observations in patients with Parkinson's disease. Age was shown to be a crucial factor for the aggregation and propagation of alpha-synuclein, highlighting the importance of using aged animals in preclinical studies for better understanding of age-dependent interactions.
Review Biochemistry & Molecular Biology

Glutathione in the Brain

Koji Aoyama

Summary: Glutathione (GSH) depletion in neurons is common in neurodegenerative diseases and can lead to neurodegeneration. Excitatory amino acid carrier 1 (EAAC1) plays a central role in regulating neuronal GSH production, making it a potential target for therapeutic strategies in these diseases.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Neurosciences

α-Synuclein pathology in Parkinson disease activates homeostatic NRF2 anti-oxidant response

Alberto Delaidelli et al.

Summary: The pathological accumulation of alpha-synuclein impairs redox homeostasis in the nervous system, leading to nuclear NRF2 accumulation and alterations in NRF2-responsive genes. Using a transgenic mouse model, it was observed that neuronal populations with phosphorylated aSyn showed increased nuclear NRF2 and abnormal anti-oxidant and inflammatory gene response in the affected neuraxis. Boosting neuronal anti-oxidant response may be a promising strategy to mitigate neurodegeneration in PD and related diseases.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2021)

Article Multidisciplinary Sciences

Mirtazapine exerts astrocyte-mediated dopaminergic neuroprotection

Ryo Kikuoka et al.

SCIENTIFIC REPORTS (2020)

Article Biochemistry & Molecular Biology

Region-Specific Neuroprotective Features of Astrocytes against Oxidative Stress Induced by 6-Hydroxydopamine

Masato Asanuma et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Neurosciences

Brain-First versus Gut-First Parkinson's Disease: A Hypothesis

Per Borghammer et al.

JOURNAL OF PARKINSONS DISEASE (2019)

Article Pharmacology & Pharmacy

The gut-brain axis in Parkinson's disease: Possibilities for food-based therapies

Paula Perez-Pardo et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2017)

Article Neurosciences

Zonisamide attenuates lactacystin-induced parkinsonism in mice without affecting system xc-

Eduard Bentea et al.

EXPERIMENTAL NEUROLOGY (2017)

Article Neurosciences

Phase IIb Study of Intranasal Glutathione in Parkinson's Disease

Laurie K. Mischley et al.

JOURNAL OF PARKINSONS DISEASE (2017)

Review Pharmacology & Pharmacy

Therapeutic Strategy of Targeting Astrocytes for Neuroprotection in Parkinson's Disease

Ikuko Miyazaki et al.

CURRENT PHARMACEUTICAL DESIGN (2017)

Review Biochemistry & Molecular Biology

Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease

Brent R. Stockwell et al.

Article Biochemistry & Molecular Biology

Neuroprotective effects of levetiracetam target xCT in astrocytes in parkinsonian mice

Ikuko Miyazaki et al.

JOURNAL OF NEUROCHEMISTRY (2016)

Article Biochemistry & Molecular Biology

Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson's Disease

Timothy R. Sampson et al.

Article Nutrition & Dietetics

L-Theanine protects against excess dopamine-induced neurotoxicity in the presence of astrocytes

Mika Takeshima et al.

JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION (2016)

Review Food Science & Technology

Multiple regulations of Keap1/Nrf2 system by dietary phytochemicals

Si Qin et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2016)

Review Cell Biology

Sulforaphane and Other Nutrigenomic Nrf2 Activators: Can the Clinician's Expectation Be Matched by the Reality?

Christine A. Houghton et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2016)

Article Neurosciences

Central nervous system uptake of intranasal glutathione in Parkinson's disease

Laurie K. Mischley et al.

NPJ PARKINSONS DISEASE (2016)

Article Clinical Neurology

Vagotomy and Subsequent Risk of Parkinson's Disease

Elisabeth Svensson et al.

ANNALS OF NEUROLOGY (2015)

Article Biotechnology & Applied Microbiology

6-Hydroxydopamine and lipopolysaccharides induced DNA damage in astrocytes: Involvement of nitric oxide and mitochondria (Publication with Expression of Concern. See vol. 878, 2022)

Sonam Gupta et al.

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS (2015)

Review Clinical Neurology

Pathogenesis of Parkinson disease-the gut-brain axis and environmental factors

Lisa Klingelhoefer et al.

NATURE REVIEWS NEUROLOGY (2015)

Article Multidisciplinary Sciences

Striatal Astrocytes Act as a Reservoir for L-DOPA

Masato Asanuma et al.

PLOS ONE (2014)

Article Clinical Neurology

Pramipexole in patients with early Parkinson's disease (PROUD): a randomised delayed-start trial

Anthony H. V. Schapira et al.

LANCET NEUROLOGY (2013)

Article Clinical Neurology

Promises of novel multi-target neuroprotective and neurorestorative drugs for Parkinson's disease

Moussa B.H. Youdim et al.

PARKINSONISM & RELATED DISORDERS (2013)

Article Biochemistry & Molecular Biology

CNS delivery of l-dopa by a new hybrid glutathione-methionine peptidomimetic prodrug

Francesco Pinnen et al.

AMINO ACIDS (2012)

Article Clinical Neurology

N-Acetylcysteine Prevents Loss of Dopaminergic Neurons in the EAAC1-/- Mouse

Ari E. Berman et al.

ANNALS OF NEUROLOGY (2011)

Article Biochemistry & Molecular Biology

Ammonia increases nitric oxide, free Zn2+, and metallothionein mRNA expression in cultured rat astrocytes

Carolin Kruczek et al.

BIOLOGICAL CHEMISTRY (2011)

Article Biochemistry & Molecular Biology

Polyphenols activate Nrf2 in astrocytes via H2O2, semiquinones, and quinones

Hilla Erlank et al.

FREE RADICAL BIOLOGY AND MEDICINE (2011)

Article Genetics & Heredity

Up-regulation of metallothionein gene expression in Parkinsonian astrocytes

Gregory J. Michael et al.

NEUROGENETICS (2011)

Article Clinical Neurology

Neuroprotective Effects of Zonisamide Target Astrocyte

Masato Asanuma et al.

ANNALS OF NEUROLOGY (2010)

Review Biochemistry & Molecular Biology

Neuroprotective Herbs and Foods from Different Traditional Medicines and Diets

Marcello Iriti et al.

MOLECULES (2010)

Review Clinical Neurology

A timeline for Parkinson's disease

Christopher H. Hawkes et al.

PARKINSONISM & RELATED DISORDERS (2010)

Article Biochemistry & Molecular Biology

The Nrf2-ARE cytoprotective pathway in astrocytes

Marcelo R. Vargas et al.

EXPERT REVIEWS IN MOLECULAR MEDICINE (2009)

Article Clinical Neurology

Randomized, Double-Blind, Pilot Evaluation of Intravenous Glutathione in Parkinson's Disease

Robert A. Hauser et al.

MOVEMENT DISORDERS (2009)

Review Biochemistry & Molecular Biology

Approaches to Prevent Dopamine Quinone-Induced Neurotoxicity

Ikuko Miyazaki et al.

NEUROCHEMICAL RESEARCH (2009)

Article Multidisciplinary Sciences

Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson's disease: Critical role for the astrocyte

Pei-Chun Chen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Biochemistry & Molecular Biology

Effects of theanine, a unique amino acid in tea leaves, on memory in a rat behavioral test

Takashi Yamada et al.

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2008)

Article Neurosciences

Glial dysfunction in parkin null mice:: Effects of aging

Rosa M. Solano et al.

JOURNAL OF NEUROSCIENCE (2008)

Article Neurosciences

Prarnipexole has astrocyte-mediated neuroprotective effects against lactacystin toxicity

Keiko Imamura et al.

NEUROSCIENCE LETTERS (2008)

Article Neurosciences

Oxidative stress on EAAC1 is involved in MPTP-induced glutathione depletion and motor dysfunction

Koji Aoyama et al.

EUROPEAN JOURNAL OF NEUROSCIENCE (2008)

Review Pharmacology & Pharmacy

Dopamine D3 receptor agonists for protection and repair in Parkinson's disease

Jeffrey N. Joyce et al.

CURRENT OPINION IN PHARMACOLOGY (2007)

Article Medicine, Research & Experimental

Metallothionein redox cycle and function

Y. James Kang

EXPERIMENTAL BIOLOGY AND MEDICINE (2006)

Review Biochemistry & Molecular Biology

Metallothioneins are multipurpose neuroprotectants during brain pathology

M Penkowa

FEBS JOURNAL (2006)

Article Biochemistry & Molecular Biology

Dopamine covalently modifies and functionally inactivates parkin

MJ LaVoie et al.

NATURE MEDICINE (2005)

Article Multidisciplinary Sciences

Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes

MI Kang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Article Multidisciplinary Sciences

Protection against electrophile and oxidant stress by induction of the phase 2 response: Fate of cysteines of the Keap1 sensor modified by inducers

N Wakabayashi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Article Nutrition & Dietetics

Potential synergy of phytochemicals in cancer prevention: Mechanism of action

RH Liu

JOURNAL OF NUTRITION (2004)

Review Pharmacology & Pharmacy

Novel therapeutic effects of the anti-convulsant, zonisamide, on Parkinson's disease

M Murata

CURRENT PHARMACEUTICAL DESIGN (2004)

Article Multidisciplinary Sciences

The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam

BA Lynch et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Article Geriatrics & Gerontology

Expression of NAD(P)H:quinone oxidoreductase in the normal and Parkinsonian substantia nigra

FL van Muiswinkel et al.

NEUROBIOLOGY OF AGING (2004)

Article Pharmacology & Pharmacy

Localization and photoaffinity labelling of the levetiracetam binding site in rat brain and certain cell lines

B Fuks et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2003)

Article Pharmacology & Pharmacy

Binding characteristics of [3H]ucb 30889 to levetiracetam binding sites in rat brain

M Gillard et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2003)

Review Geriatrics & Gerontology

Staging of brain pathology related to sporadic Parkinson's disease

H Braak et al.

NEUROBIOLOGY OF AGING (2003)

Article Biochemistry & Molecular Biology

Apoptosis-inducing neurotoxicity of dopamine and its metabolites via reactive quinone generation in neuroblastoma cells

ME Haque et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2003)

Review Pharmacology & Pharmacy

Neuroprotective effects of the green tea components theanine and catechins

T Kakuda

BIOLOGICAL & PHARMACEUTICAL BULLETIN (2002)

Article Multidisciplinary Sciences

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

AT Dinkova-Kostova et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

Article Clinical Neurology

Selective blockade of N-type calcium channels by levetiracetam

EA Lukyanetz et al.

EPILEPSIA (2002)

Article Neurosciences

Zonisamide has beneficial effects on Parkinson's disease patients

M Murata et al.

NEUROSCIENCE RESEARCH (2001)

Article Biochemistry & Molecular Biology

Reaction of oxidized dopamine with endogenous cysteine residues in the human dopamine transporter

RE Whitehead et al.

JOURNAL OF NEUROCHEMISTRY (2001)

Article Biochemistry & Molecular Biology

Molecular mechanism in activation of glutathione system by ropinirole, a selective dopamine D2 agonist

K Tanaka et al.

NEUROCHEMICAL RESEARCH (2001)

Article Biochemistry & Molecular Biology

Astrocytes provide cysteine to neurons by releasing glutathione

XF Wang et al.

JOURNAL OF NEUROCHEMISTRY (2000)