期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 22, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/ijms22126422
关键词
TNNI3K; supraventricular arrhythmias; cardiomyopathy; cardiac regeneration; conduction disease; hypertrophy; myocardial infarction; phosphorylation
资金
- Netherlands CardioVascular Research Initiative [CVON2017-15 RESCUED]
- Dutch Research Council: NWO Talent Scheme [VIDI-91718361]
TNNI3K, an understudied kinase mainly expressed in the heart, has been implicated in various cardiac phenotypes and physiological processes. Human genetic variants in TNNI3K are associated with supraventricular arrhythmias, conduction disease, and cardiomyopathy. Studies in mice also suggest its involvement in cardiac hypertrophy, regeneration, and recovery after ischemia/reperfusion injury, with potential as a target for clinical treatments in different cardiac diseases.
In the two decades since the discovery of TNNI3K it has been implicated in multiple cardiac phenotypes and physiological processes. TNNI3K is an understudied kinase, which is mainly expressed in the heart. Human genetic variants in TNNI3K are associated with supraventricular arrhythmias, conduction disease, and cardiomyopathy. Furthermore, studies in mice implicate the gene in cardiac hypertrophy, cardiac regeneration, and recovery after ischemia/reperfusion injury. Several new papers on TNNI3K have been published since the last overview, broadening the clinical perspective of TNNI3K variants and our understanding of the underlying molecular biology. We here provide an overview of the role of TNNI3K in cardiomyopathy and arrhythmia covering both a clinical perspective and basic science advancements. In addition, we review the potential of TNNI3K as a target for clinical treatments in different cardiac diseases.
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