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Mitochondrial Modulations, Autophagy Pathways Shifts in Viral Infections: Consequences of COVID-19

期刊

出版社

MDPI
DOI: 10.3390/ijms22158180

关键词

mitochondria; SARS-COV2; potential targets; autophagy; COVID-19; viral infections

资金

  1. NHLBI [RO1HL076801]
  2. NIDCR [RO1DE014079]

向作者/读者索取更多资源

Mitochondria are crucial organelles in regulating intracellular events, which can be altered by viruses to induce cellular stress and promote viral proliferation. Autophagy plays a key role in SARS-COV2-mediated COVID-19 and serves as a potential target for anti-viral therapy.
Mitochondria are vital intracellular organelles that play an important role in regulating various intracellular events such as metabolism, bioenergetics, cell death (apoptosis), and innate immune signaling. Mitochondrial fission, fusion, and membrane potential play a central role in maintaining mitochondrial dynamics and the overall shape of mitochondria. Viruses change the dynamics of the mitochondria by altering the mitochondrial processes/functions, such as autophagy, mitophagy, and enzymes involved in metabolism. In addition, viruses decrease the supply of energy to the mitochondria in the form of ATP, causing viruses to create cellular stress by generating ROS in mitochondria to instigate viral proliferation, a process which causes both intra- and extra-mitochondrial damage. SARS-COV2 propagates through altering or changing various pathways, such as autophagy, UPR stress, MPTP and NLRP3 inflammasome. Thus, these pathways act as potential targets for viruses to facilitate their proliferation. Autophagy plays an essential role in SARS-COV2-mediated COVID-19 and modulates autophagy by using various drugs that act on potential targets of the virus to inhibit and treat viral infection. Modulated autophagy inhibits coronavirus replication; thus, it becomes a promising target for anti-coronaviral therapy. This review gives immense knowledge about the infections, mitochondrial modulations, and therapeutic targets of viruses.

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