期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 22, 期 11, 页码 -出版社
MDPI
DOI: 10.3390/ijms22115887
关键词
brain energy metabolism; glucose; neurodegenerative disease; hypoxia; metabolic reprogramming
资金
- National Natural Science Foundation of China [81971198]
- Beijing Municipal Natural Science Foundation [7192103]
- Chinese Ministry of Science and Technology [2019YFA0508603]
- China Postdoctoral Science Foundation [2020M670103]
Glucose is the main energy substrate for the adult brain and plays a crucial role in neuronal function. Dysregulation of glucose metabolism is commonly observed in neurodegenerative diseases, highlighting the importance of understanding metabolic adaptation mechanisms and potential interventions. Mitochondrial dysfunction, decreased glucose uptake, and hypoxia are key factors in neurodegeneration and may serve as targets for therapeutic strategies.
Glucose is the main circulating energy substrate for the adult brain. Owing to the high energy demand of nerve cells, glucose is actively oxidized to produce ATP and has a synergistic effect with mitochondria in metabolic pathways. The dysfunction of glucose metabolism inevitably disturbs the normal functioning of neurons, which is widely observed in neurodegenerative disease. Understanding the mechanisms of metabolic adaptation during disease progression has become a major focus of research, and interventions in these processes may relieve the neurons from degenerative stress. In this review, we highlight evidence of mitochondrial dysfunction, decreased glucose uptake, and diminished glucose metabolism in different neurodegeneration models such as Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and Huntington's disease (HD). We also discuss how hypoxia, a metabolic reprogramming strategy linked to glucose metabolism in tumor cells and normal brain cells, and summarize the evidence for hypoxia as a putative therapy for general neurodegenerative disease.
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