Immune Prophylaxis and Therapy for Human Cytomegalovirus Infection

Human Cytomegalovirus (HCMV) infection is widespread and can result in severe sequelae in susceptible populations. Primary HCMV infection of naive individuals results in life-long latency characterized by frequent and sporadic reactivations. HCMV infection elicits a robust antibody response, including neutralizing antibodies that can block the infection of susceptible cells in vitro and in vivo. Thus, antibody products and vaccines hold great promise for the prevention and treatment of HCMV, but to date, most attempts to demonstrate their safety and efficacy in clinical trials have been unsuccessful. In this review we summarize publicly available data on these products and highlight new developments and approaches that could assist in successful translation of HCMV immunotherapies.

Automated summary

HCMV infection is widespread and can have severe consequences, but attempts to demonstrate the safety and efficacy of antibody products and vaccines in clinical trials have been largely unsuccessful so far. New developments and approaches are being highlighted to assist in successful translation of HCMV immunotherapies.