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Protective effects of dietary avocado oil on impaired electron transport chain function and exacerbated oxidative stress in liver mitochondria from diabetic rats
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Ursodeoxycholic acid exerts farnesoid X receptor-antagonistic effects on bile acid and lipid metabolism in morbid obesity
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Sab (Sh3bp5) dependence of JNK mediated inhibition of mitochondrial respiration in palmitic acid induced hepatocyte lipotoxicity
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Effect of aerobic exercise training dose on liver fat and visceral adiposity
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Glucose fluctuation increased hepatocyte apoptosis under lipotoxicity and the involvement of mitochondrial permeability transition opening
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Hepatokines as a Link between Obesity and Cardiovascular Diseases
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932 Pentoxifylline Improves Non-Invasive Serum Markers of Fibrosis: Combined Results From 2 Randomized, Placebo-Controlled Trials
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Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease
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The pan-caspase inhibitor Emricasan (IDN-6556) decreases liver injury and fibrosis in a murine model of non-alcoholic steatohepatitis
Fernando J. Barreyro et al.
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Dynamic carbon 13 breath tests for the study of liver function and gastric emptying
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GASTROENTEROLOGY REPORT (2015)
Involvement of the mitochondrial permeability transition pore in chronic ethanol-mediated liver injury in mice
Adrienne L. King et al.
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CerS2 Haploinsufficiency Inhibits β-Oxidation and Confers Susceptibility to Diet-Induced Steatohepatitis and Insulin Resistance
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Resveratrol Does Not Benefit Patients With Nonalcoholic Fatty Liver Disease
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The dual peroxisome proliferator-activated receptor alpha/delta agonist GFT505 exerts anti-diabetic effects in db/db mice without peroxisome proliferator-activated receptor gamma-associated adverse cardiac effects
Remy Hanf et al.
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Oxysterols induce mitochondrial impairment and hepatocellular toxicity in non-alcoholic fatty liver disease
Bellanti Francesco et al.
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The effects of dietary restriction on oxidative stress in rodents
Michael E. Walsh et al.
FREE RADICAL BIOLOGY AND MEDICINE (2014)
The mitochondrial-targeted antioxidant MitoQ ameliorates metabolic syndrome features in obesogenic diet-fed rats better than Apocynin or Allopurinol
Christine Feillet-Coudray et al.
FREE RADICAL RESEARCH (2014)
No Significant Effects of Ethyl-Eicosapentanoic Acid on Histologic Features of Nonalcoholic Steatohepatitis in a Phase 2 Trial
Arun J. Sanyal et al.
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Increased De Novo Lipogenesis Is a Distinct Characteristic of Individuals With Nonalcoholic Fatty Liver Disease
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GASTROENTEROLOGY (2014)
Interferon Regulatory Factor 3 Constrains IKKβ/NF-κB Signaling to Alleviate Hepatic Steatosis and Insulin Resistance
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Role of Mitochondria in Nonalcoholic Fatty Liver Disease
Fatiha Nassir et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2014)
The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes
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NATURE (2014)
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Prevalence of Nonalcoholic Fatty Liver Disease in the United States: The Third National Health and Nutrition Examination Survey, 1988-1994
Mariana Lazo et al.
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Pleiotropic Roles of Bile Acids in Metabolism
Thomas Q. de Aguiar Vallim et al.
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Lazar A. Bojic et al.
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Bertrand Cariou et al.
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Efficacy and Safety of the Farnesoid X Receptor Agonist Obeticholic Acid in Patients With Type 2 Diabetes and Nonalcoholic Fatty Liver Disease
Sunder Mudaliar et al.
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Glycogen synthase kinase 3-mediated voltage-dependent anion channel phosphorylation controls outer mitochondrial membrane permeability during lipid accumulation
Cecile Martel et al.
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Hepatoprotective Effects of the Dual Peroxisome Proliferator-Activated Receptor Alpha/Delta Agonist, GFT505, in Rodent Models of Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis
Bart Staels et al.
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Berberine reverts hepatic mitochondrial dysfunction in high-fat fed rats: A possible role for SirT3 activation
Joao Soeiro Teodoro et al.
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Rohit Loomba et al.
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The biophysics and cell biology of lipid droplets
Abdou Rachid Thiam et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2013)
Identification of a Mitochondrial Target of Thiazolidinedione Insulin Sensitizers (mTOT)-Relationship to Newly Identified Mitochondrial Pyruvate Carrier Proteins
Jerry R. Colca et al.
PLOS ONE (2013)
PNPLA3-Associated Steatohepatitis: Toward a Gene-Based Classification of Fatty Liver Disease
Marcin Krawczyk et al.
SEMINARS IN LIVER DISEASE (2013)
A silybin-phospholipids complex counteracts rat fatty liver degeneration and mitochondrial oxidative changes
Ignazio Grattagliano et al.
WORLD JOURNAL OF GASTROENTEROLOGY (2013)
Fatty acid transport proteins, implications in physiology and disease
Melissa Kazantzis et al.
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Mechanisms for Insulin Resistance: Common Threads and Missing Links
Varman T. Samuel et al.
CELL (2012)
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Increased Hepatic Synthesis and Dysregulation of Cholesterol Metabolism Is Associated with the Severity of Nonalcoholic Fatty Liver Disease
Hae-Ki Min et al.
CELL METABOLISM (2012)
Impact of current treatments on liver disease, glucose metabolism and cardiovascular risk in non-alcoholic fatty liver disease (NAFLD): a systematic review and meta-analysis of randomised trials
G. Musso et al.
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The mitochondria-targeted antioxidant MitoQ decreases features of the metabolic syndrome in ATM+/-/ApoE-/- mice
John R. Mercer et al.
FREE RADICAL BIOLOGY AND MEDICINE (2012)
Silybin combined with phosphatidylcholine and vitamin E in patients with nonalcoholic fatty liver disease: A randomized controlled trial
Carmela Loguercio et al.
FREE RADICAL BIOLOGY AND MEDICINE (2012)
Pioglitazone and Vitamin E for Nonalcoholic Steatohepatitis: A Cost Utility Analysis
Suzanne E. Mahady et al.
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Exercise and non-alcoholic fatty liver disease: A systematic review and meta-analysis
Shelley E. Keating et al.
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Omega-3 supplementation and non-alcoholic fatty liver disease: A systematic review and meta-analysis
Helen M. Parker et al.
JOURNAL OF HEPATOLOGY (2012)
Lifestyle interventions for the treatment of non-alcoholic fatty liver disease in adults: A systematic review
Christian Thoma et al.
JOURNAL OF HEPATOLOGY (2012)
Bile acid receptors as targets for the treatment of dyslipidemia and cardiovascular disease
Geoffrey Porez et al.
JOURNAL OF LIPID RESEARCH (2012)
Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR
Anna C. Calkin et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2012)
Improvement of Nonalcoholic Fatty Liver Disease After Bariatric Surgery in Morbidly Obese Chinese Patients
Chi-Ming Tai et al.
OBESITY SURGERY (2012)
Role of ceramides in nonalcoholic fatty liver disease
Mangesh Pagadala et al.
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2012)
Mitochondrial Roles and Cytoprotection in Chronic Liver Injury
Davide Degli Esposti et al.
BIOCHEMISTRY RESEARCH INTERNATIONAL (2012)
Enteric-coated cysteamine for the treatment of paediatric non-alcoholic fatty liver disease
R. Dohil et al.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2011)
Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults
G. Vernon et al.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2011)
Skeletal muscle and beyond: the role of exercise as a mediator of systemic mitochondrial biogenesis
Jonathan P. Little et al.
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM (2011)
Excessive Hepatic Mitochondrial TCA Cycle and Gluconeogenesis in Humans with Nonalcoholic Fatty Liver Disease
Nishanth E. Sunny et al.
CELL METABOLISM (2011)
Changes in the Prevalence of the Most Common Causes of Chronic Liver Diseases in the United States From 1988 to 2008
Zobair M. Younossi et al.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2011)
Liver ATP Synthesis Is Lower and Relates to Insulin Sensitivity in Patients With Type 2 Diabetes
Albrecht Ingo Schmid et al.
DIABETES CARE (2011)
Prevalence of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis Among a Largely Middle-Aged Population Utilizing Ultrasound and Liver Biopsy: A Prospective Study
Christopher D. Williams et al.
GASTROENTEROLOGY (2011)
Pentoxifylline Improves Nonalcoholic Steatohepatitis: A Randomized Placebo-Controlled Trial
Claudia O. Zein et al.
HEPATOLOGY (2011)
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Karima Begriche et al.
JOURNAL OF HEPATOLOGY (2011)
Oxidation of Hepatic Carnitine Palmitoyl Transferase-I (CPT-I) Impairs Fatty Acid Beta-Oxidation in Rats Fed a Methionine-Choline Deficient Diet
Gaetano Serviddio et al.
PLOS ONE (2011)
Caloric restriction and redox state: Does this diet increase or decrease oxidant production?
Alicia J. Kowaltowski
REDOX REPORT (2011)
Human Fatty Liver Disease: Old Questions and New Insights
Jonathan C. Cohen et al.
SCIENCE (2011)
Expanding roles for lipid droplets
Andrew S. Greenberg et al.
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2011)
Apoptosis in nonalcoholic fatty liver disease: diagnostic and therapeutic implications
Naim Alkhouri et al.
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY (2011)
Meta-analysis: insulin sensitizers for the treatment of non-alcoholic steatohepatitis
M. O. Rakoski et al.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2010)
Pyruvate kinase in pig liver mitochondria
Roberto Pizzuto et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2010)
Nonalcoholic fatty liver disease
Marcin Krawczyk et al.
BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY (2010)
Genistein and daidzein prevent low potassium-dependent apoptosis of cerebellar granule cells
Anna Atlante et al.
BIOCHEMICAL PHARMACOLOGY (2010)
13C-octanoic acid breath test (OBT) with a new test meal (EXPIROGer®): Toward standardization for testing gastric emptying of solids
Francesco Perri et al.
DIGESTIVE AND LIVER DISEASE (2010)
13C-breath tests for clinical investigation of liver mitochondrial function
Ignazio Grattagliano et al.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2010)
Randomized Controlled Trial Testing the Effects of Weight Loss on Nonalcoholic Steatohepatitis
Kittichai Promrat et al.
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Long-Term Efficacy of Rosiglitazone in Nonalcoholic Steatohepatitis: Results of the Fatty Liver Improvement by Rosiglitazone Therapy (FLIRT 2) Extension Trial
Vlad Ratziu et al.
HEPATOLOGY (2010)
A Meta-Analysis of Randomized Trials for the Treatment of Nonalcoholic Fatty Liver Disease
Giovanni Musso et al.
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Effects of a 1-year dietary intervention with n-3 polyunsaturated fatty acid-enriched olive oil on non-alcoholic fatty liver disease patients: a preliminary study
Francesco Sofi et al.
INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION (2010)
Antioxidant Activities and Xanthine Oxidase Inhibitory Effects of Extracts and Main Polyphenolic Compounds Obtained from Geranium sibiricum L.
Nan Wu et al.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2010)
Palmitoleate attenuates palmitate-induced Bim and PUMA up-regulation and hepatocyte lipoapoptosis
Yuko Akazawa et al.
JOURNAL OF HEPATOLOGY (2010)
Adoption of PERILIPIN as a unifying nomenclature for the mammalian PAT-family of intracellular lipid storage droplet proteins
Alan R. Kimmel et al.
JOURNAL OF LIPID RESEARCH (2010)
Endurance exercise causes mitochondrial and oxidative stress in rat liver: Effects of a combination of mitochondrial targeting nutrients
Lijuan Sun et al.
LIFE SCIENCES (2010)
The mitochondria-targeted anti-oxidant mitoquinone decreases liver damage in a phase II study of hepatitis C patients
Edward J. Gane et al.
LIVER INTERNATIONAL (2010)
Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis.
Arun J. Sanyal et al.
NEW ENGLAND JOURNAL OF MEDICINE (2010)
The latest idea in NAFLD/NASH pathogenesis
Masafumi Ono et al.
CLINICAL JOURNAL OF GASTROENTEROLOGY (2010)
Bariatric surgery for non-alcoholic steatohepatitis in obese patients
N. C. Chavaez-Tapia et al.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS (2010)
Oxidative Stress-Mediated Mitochondrial Dysfunction Contributes to Angiotensin II-Induced Nonalcoholic Fatty Liver Disease in Transgenic Ren2 Rats
Yongzhong Wei et al.
AMERICAN JOURNAL OF PATHOLOGY (2009)
Metformin and Insulin Suppress Hepatic Gluconeogenesis through Phosphorylation of CREB Binding Protein
Ling He et al.
CELL (2009)
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Valerian E. Kagan et al.
FREE RADICAL BIOLOGY AND MEDICINE (2009)
Prospective Study of the Long-Term Effects of Bariatric Surgery on Liver Injury in Patients Without Advanced Disease
Philippe Mathurin et al.
GASTROENTEROLOGY (2009)
Increased Intestinal Permeability and Tight Junction Alterations in Nonalcoholic Fatty Liver Disease
Luca Miele et al.
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Hepatic Lipid Partitioning and Liver Damage in Nonalcoholic Fatty Liver Disease ROLE OF STEAROYL-CoA DESATURASE
Zheng Zheng Li et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Silybin, a component of sylimarin, exerts anti-inflammatory and anti-fibrogenic effects on human hepatic stellate cells
Marco Trappoliere et al.
JOURNAL OF HEPATOLOGY (2009)
Liver Function as Assessed by Breath Tests in Patients With Hepatocellular Carcinoma
Vincenzo O. Palmieri et al.
JOURNAL OF SURGICAL RESEARCH (2009)
Lipolysis and lipid mobilization in human adipose tissue
Max Lafontan et al.
PROGRESS IN LIPID RESEARCH (2009)
Alcohol consumption is associated with progression of hepatic fibrosis in non-alcoholic fatty liver disease
Mattias Ekstedt et al.
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY (2009)
Resveratrol improves non-alcoholic fatty liver disease by activating AMP-activated protein kinase
Jing Shang et al.
ACTA PHARMACOLOGICA SINICA (2008)
Severe NAFLD with hepatic necroinflammatory changes in mice fed trans fats and a high-fructose corn syrup equivalent
Laura H. Tetri et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2008)
Daily exercise increases hepatic fatty acid oxidation and prevents steatosis in Otsuka Long-Evans Tokushima Fatty rats
R. Scott Rector et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2008)
Alternative M2 activation of Kupffer cells by PPARδ ameliorates obesity-induced insulin resistance
Justin I. Odegaard et al.
CELL METABOLISM (2008)
Mitochondria and L-lactate metabolism
Salvatore Passarella et al.
FEBS LETTERS (2008)
Rosiglitazone for nonalcoholic steatohepatitis: One-year results of the randomized placebo-controlled fatty liver improvement with rosiglitazone therapy (FLIRT) trial
Vlad Ratziu et al.
GASTROENTEROLOGY (2008)
Randomized, placebo-controlled trial of pioglitazone in nondiabetic subjects with nonalcoholic steatohepatitis
Guruprasad P. Aithal et al.
GASTROENTEROLOGY (2008)
Kinetic Analysis of Permeation of Mitochondria-Targeted Antioxidants Across Bilayer Lipid Membranes
Tatyana I. Rokitskaya et al.
JOURNAL OF MEMBRANE BIOLOGY (2008)
Cessation of daily exercise dramatically alters precursors of hepatic steatosis in Otsuka Long-Evans Tokushima Fatty (OLETF) rats
R. Scott Rector et al.
JOURNAL OF PHYSIOLOGY-LONDON (2008)
Efficacy of atorvastatin for the treatment of nonalcoholic steatohepatitis with dyslipidemia
Hideyuki Hyogo et al.
METABOLISM-CLINICAL AND EXPERIMENTAL (2008)
Nonalcoholic fatty liver disease and mitochondrial dysfunction
Yongzhong Wei et al.
WORLD JOURNAL OF GASTROENTEROLOGY (2008)
Activation of peroxisome proliferator-activated receptor (PPAR)δ promotes reversal of multiple metabolic abnormalities, reduces oxidative stress, and increases fatly acid oxidation in moderately obese men
Ulf Riserus et al.
DIABETES (2008)
Lysophosphatidylcholine as a death effector in the lipoapoptosis of hepatocytes
Myoung Sook Han et al.
JOURNAL OF LIPID RESEARCH (2008)
Novel interactions of mitochondria and reactive oxygen/nitrogen species in alcohol mediated liver disease
Sudheer K. Mantena et al.
WORLD JOURNAL OF GASTROENTEROLOGY (2007)
A lipidomic analysis of nonalcoholic fatty liver disease
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HEPATOLOGY (2007)
Mitochondrial dysfunction in rat with nonalcoholic fatty liver Involvement of complex I, reactive oxygen species and cardiolipin
Giuseppe Petrosillo et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2007)
Nitrosative stress predicts the presence and severity of nonalcoholic fatty liver at different stages of the development of insulin resistance and metabolic syndrome: possible role of vitamin A intake
Giovanni Musso et al.
AMERICAN JOURNAL OF CLINICAL NUTRITION (2007)
Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis
Kanji Yamaguchi et al.
HEPATOLOGY (2007)
A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis
Renata Belfort et al.
NEW ENGLAND JOURNAL OF MEDICINE (2006)
Caspase-dependent alteration of the ADP/ATP translocator triggers the mitochondrial permeability transition which is not required for the low-potassium-dependent apoptosis of cerebellar granule cells
A Atlante et al.
JOURNAL OF NEUROCHEMISTRY (2006)
Roux-en-Y gastric bypass improves the nonalcoholic steatohepatitis (NASH) of morbid obesity
SR de Almeida et al.
OBESITY SURGERY (2006)
Roux-en-Y gastric bypass improves liver histology in patients with non-alcoholic fatty liver disease
JM Clark et al.
OBESITY RESEARCH (2005)
NASH: a mitochondrial disease
D Pessayre et al.
JOURNAL OF HEPATOLOGY (2005)
FGF-21 as a novel metabolic regulator
A Kharitonenkov et al.
JOURNAL OF CLINICAL INVESTIGATION (2005)
Stearoyl-CoA desaturase as a new drug target for obesity treatment
A Dobrzyn et al.
OBESITY REVIEWS (2005)
Reversal of nonalcoholic hepatic steatosis, hepatic insulin resistance, and hyperglycemia by moderate weight reduction in patients with type 2 diabetes
KF Petersen et al.
DIABETES (2005)
Measurement of hepatic functional mass by means of 13C-methacetin and 13C-phenylalanine breath tests in chronic liver disease: Comparison with Child-Pugh score and serum bile acid levels
D. Festi et al.
WORLD JOURNAL OF GASTROENTEROLOGY (2005)
Stearoyl-CoA desaturase 1 deficiency increases fatty acid oxidation by activating AMP-activated protein kinase in liver
P Dobrzyn et al.
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Ethnic differences in the prevalence of cryptogenic cirrhosis
JD Browning et al.
AMERICAN JOURNAL OF GASTROENTEROLOGY (2004)
Supplementation of endothelial cells with mitochondria-targeted antioxidants inhibit peroxide-induced mitochondrial iron uptake, oxidative damage, and apoptosis
A Dhanasekaran et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Fine-tuning the hydrophobicity of a mitochondria-targeted antioxidant
J Asin-Cayuela et al.
FEBS LETTERS (2004)
A Pilot Study of Vitamin E Versus Vitamin E and Pioglitazone for the Treatment of Nonalcoholic Steatohepatitis
Arun J. Sanyal et al.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2004)
A pilot study of ploglitazone treatment for nonalcoholic steatohepatitis
K Promrat et al.
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Fibroblast growth factor 19 increases metabolic rate I and reverses dietary and leptlin-deficient diabetes
L Fu et al.
ENDOCRINOLOGY (2004)
Nonalcoholic fatty liver disease: Improvement in liver histological analysis with weight loss
JB Dixon et al.
HEPATOLOGY (2004)
Apoptosis shifts to necrosis via intermediate types of cell death by a mechanism depending on c-myc and bcl-2 expression
L Papucci et al.
CELL AND TISSUE RESEARCH (2004)
Hepatic mitochondrial beta-oxidation in patients with nonalcoholic steatohepatitis assessed by 13C-octanoate breath test
L Miele et al.
AMERICAN JOURNAL OF GASTROENTEROLOGY (2003)
Delivery of bioactive molecules to mitochondria in vivo
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
The role of mitochondrial transport in energy metabolism
S Passarella et al.
MITOCHONDRION (2003)
In situ detection of lipid peroxidation and oxidative DNA damage in non-alcoholic fatty liver diseases
S Seki et al.
JOURNAL OF HEPATOLOGY (2002)
SREBPs: Transcriptional mediators of lipid homeostasis
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COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY (2002)
Ursodeoxycholic acid 'mechanisms of action and clinical use in hepatobiliary disorders'
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JOURNAL OF HEPATOLOGY (2001)
Nonalcoholic steatohepatitis: Association of insulin resistance and mitochondrial abnormalities
AJ Sanyal et al.
GASTROENTEROLOGY (2001)
The use of silymarin in the treatment of liver diseases
R Saller et al.
DRUGS (2001)
Mitochondria in steatohepatitis
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Perilipin A increases triacylglycerol storage by decreasing the rate of triacylglycerol hydrolysis
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VDAC regulation by the Bcl-2 family of proteins
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Cytochrome P450-generated reactive metabolites cause mitochondrial permeability transition, caspase activation, and apoptosis in rat hepatocytes
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Correlation between decreased expression of mitochondrial F0F1-ATP synthase and low regenerating capability of the liver after partial hepatectomy in hypothyroid rats
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JOURNAL OF BIOENERGETICS AND BIOMEMBRANES (2000)
Bile acids affect liver mitochondrial bioenergetics: Possible relevance for cholestasis therapy
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