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Longitudinal analysis of the behavioural phenotype in YAC128 (C57BL/6J) Huntington's disease transgenic mice
Simon Brooks et al.
BRAIN RESEARCH BULLETIN (2012)
Light and electron microscopic characterization of the evolution of cellular pathology in YAC128 Huntington's disease transgenic mice
Zubeyde Bayram-Weston et al.
BRAIN RESEARCH BULLETIN (2012)
Screening of Therapeutic Strategies for Huntington's Disease in YAC128 Transgenic Mice
Joana M. Gil-Mohapel
CNS NEUROSCIENCE & THERAPEUTICS (2012)
Mitochondrial-Associated Metabolic Changes and Neurodegeneration in Huntingtons Disease - from Clinical Features to the Bench
Tatiana R. Rosenstock et al.
CURRENT DRUG TARGETS (2012)
α-Synuclein levels modulate Huntington's disease in mice
Silvia Corrochano et al.
HUMAN MOLECULAR GENETICS (2012)
Marked differences in neurochemistry and aggregates despite similar behavioural and neuropathological features of Huntington disease in the full-length BACHD and YAC128 mice
Mahmoud A. Pouladi et al.
HUMAN MOLECULAR GENETICS (2012)
Selective histone deacetylase (HDAC) inhibition imparts beneficial effects in Huntingtons disease mice: implications for the ubiquitinproteasomal and autophagy systems
Haiqun Jia et al.
HUMAN MOLECULAR GENETICS (2012)
Evaluation of longitudinal 12 and 24 month cognitive outcomes in premanifest and early Huntington's disease
Julie C. Stout et al.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2012)
Deep brain stimulation in Huntington's disease: A 4-year follow-up case report
Sabine Spielberger et al.
MOVEMENT DISORDERS (2012)
The incidence and prevalence of Huntington's disease: A systematic review and meta-analysis
Tamara Pringsheim et al.
MOVEMENT DISORDERS (2012)
Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets
Mali Jiang et al.
NATURE MEDICINE (2012)
Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway
Hyunkyung Jeong et al.
NATURE MEDICINE (2012)
Evidence-based guideline: Pharmacologic treatment of chorea in Huntington disease Report of the Guideline Development Subcommittee of the American Academy of Neurology
Melissa J. Armstrong et al.
NEUROLOGY (2012)
Huntington's Disease and the Striatal Medium Spiny Neuron: Cell-Autonomous and Non-Cell-Autonomous Mechanisms of Disease
Michelle E. Ehrlich
NEUROTHERAPEUTICS (2012)
Deep brain stimulation in disabling involuntary vocalization associated with Huntington's disease
Pedro J. Garcia-Ruiz et al.
PARKINSONISM & RELATED DISORDERS (2012)
Comprehensive Behavioral and Molecular Characterization of a New Knock-In Mouse Model of Huntington's Disease: zQ175
Liliana B. Menalled et al.
PLOS ONE (2012)
A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity
Martin Jinek et al.
SCIENCE (2012)
The Sirtuin 2 Inhibitor AK-7 Is Neuroprotective in Huntington's Disease Mouse Models
Vanita Chopra et al.
CELL REPORTS (2012)
Adenoviral Astrocyte-Specific Expression of BDNF in the Striata of Mice Transgenic for Huntington's Disease Delays the Onset of the Motor Phenotype
Leticia Arregui et al.
CELLULAR AND MOLECULAR NEUROBIOLOGY (2011)
IGF-1 protects against diabetic features in an in vivo model of Huntington's disease
A. I. Duarte et al.
EXPERIMENTAL NEUROLOGY (2011)
Long-term follow-up of pallidal deep brain stimulation in two cases of Huntington's disease
Gail A. Kang et al.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2011)
Constitutive Upregulation of Chaperone-Mediated Autophagy in Huntington's Disease
Hiroshi Koga et al.
JOURNAL OF NEUROSCIENCE (2011)
Novel Regulation of Parkin Function through c-Abl-Mediated Tyrosine Phosphorylation: Implications for Parkinson's Disease
Syed Z. Imam et al.
JOURNAL OF NEUROSCIENCE (2011)
Conditional BDNF release under pathological conditions improves Huntington's disease pathology by delaying neuronal dysfunction
Albert Giralt et al.
MOLECULAR NEURODEGENERATION (2011)
Preclinical Safety of RNAi-Mediated HTT Suppression in the Rhesus Macaque as a Potential Therapy for Huntington's Disease
Jodi L. McBride et al.
MOLECULAR THERAPY (2011)
Milestones in Movement Disorders Clinical Trials: Advances and Landmark Studies
C. Warren Olanow et al.
MOVEMENT DISORDERS (2011)
Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity
Wenjun Song et al.
NATURE MEDICINE (2011)
Nicotinamide improves motor deficits and upregulates PGC-1 alpha and BDNF gene expression in a mouse model of Huntington's disease
Tyisha Hathorn et al.
NEUROBIOLOGY OF DISEASE (2011)
FK506 ameliorates cell death features in Huntington's disease striatal cell models
Tatiana R. Rosenstock et al.
NEUROCHEMISTRY INTERNATIONAL (2011)
Structural MRI detects progressive regional brain atrophy and neuroprotective effects in N171-82Q Huntington's disease mouse model
Yong Cheng et al.
NEUROIMAGE (2011)
Hdac6 Knock-Out Increases Tubulin Acetylation but Does Not Modify Disease Progression in the R6/2 Mouse Model of Huntington's Disease
Anna Bobrowska et al.
PLOS ONE (2011)
Mitochondrial Turnover and Aging of Long-Lived Postmitotic Cells: The Mitochondrial-Lysosomal Axis Theory of Aging
Alexei Terman et al.
ANTIOXIDANTS & REDOX SIGNALING (2010)
Genetically engineered mesenchymal stem cells reduce behavioral deficits in the YAC 128 mouse model of Huntington's disease
Nicholas D. Dey et al.
BEHAVIOURAL BRAIN RESEARCH (2010)
Dopamine and Glutamate in Huntington's Disease: A Balancing Act
Veronique M. Andre et al.
CNS NEUROSCIENCE & THERAPEUTICS (2010)
Wheel Running and Environmental Enrichment Differentially Modify Exon-Specific BDNF Expression in the Hippocampus of Wild-Type and Pre-motor Symptomatic Male and Female Huntington's Disease Mice
M. S. Zajac et al.
HIPPOCAMPUS (2010)
Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease
Claudia Rose et al.
HUMAN MOLECULAR GENETICS (2010)
Mitochondrial loss, dysfunction and altered dynamics in Huntington's disease
Jinho Kim et al.
HUMAN MOLECULAR GENETICS (2010)
Insulin and Insulin-like Growth Factor-1 Receptors Act as Ligand-specific Amplitude Modulators of a Common Pathway Regulating Gene Transcription
Jeremie Boucher et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
The Clinical and Genetic Features of Huntington Disease
Aaron Sturrock et al.
JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY (2010)
Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease
Marta Martinez-Vicente et al.
NATURE NEUROSCIENCE (2010)
Neural stem cell systems: physiological players or in vitro entities?
Luciano Conti et al.
NATURE REVIEWS NEUROSCIENCE (2010)
Huntington's disease: a clinical review
Raymund A. C. Roos
ORPHANET JOURNAL OF RARE DISEASES (2010)
SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis
Ruth Luthi-Carter et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function
Han Seok Ko et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Of mice, rats and men: Revisiting the quinolinic acid hypothesis of Huntington's disease
Robert Schwarcz et al.
PROGRESS IN NEUROBIOLOGY (2010)
Prevention of depressive behaviour in the YAC128 mouse model of Huntington disease by mutation at residue 586 of huntingtin
Mahmoud A. Pouladi et al.
BRAIN (2009)
The R6 lines of transgenic mice: A model for screening new therapies for Huntington's disease
Joana M. Gil et al.
BRAIN RESEARCH REVIEWS (2009)
Riluzole protects Huntington disease patients from brain glucose hypometabolism and grey matter volume loss and increases production of neurotrophins
Ferdinando Squitieri et al.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2009)
A majority of Huntington's disease patients may be treatable by individualized allele-specific RNA interference
Maria Stella Lombardi et al.
EXPERIMENTAL NEUROLOGY (2009)
Intrabody Gene Therapy Ameliorates Motor, Cognitive, and Neuropathological Symptoms in Multiple Mouse Models of Huntington's Disease
Amber L. Southwell et al.
JOURNAL OF NEUROSCIENCE (2009)
In Vivo Evidence for NMDA Receptor-Mediated Excitotoxicity in a Murine Genetic Model of Huntington Disease
Mary Y. Heng et al.
JOURNAL OF NEUROSCIENCE (2009)
Intracerebral Transplantation of Neural Stem Cells Combined With Trehalose Ingestion Alleviates Pathology in a Mouse Model of Huntington's Disease
Chia-Ron Yang et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2009)
Nonallele-specific Silencing of Mutant and Wild-type Huntingtin Demonstrates Therapeutic Efficacy in Huntington's Disease Mice
Ryan L. Boudreau et al.
MOLECULAR THERAPY (2009)
Treatment of the Symptoms of Huntington's Disease: Preliminary Results Comparing Aripiprazole and Tetrabenazine
Livia Brusa et al.
MOVEMENT DISORDERS (2009)
Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin
Shu-ichi Okamoto et al.
NATURE MEDICINE (2009)
Brain-derived neurotrophic factor in neurodegenerative diseases
Chiara Zuccato et al.
NATURE REVIEWS NEUROLOGY (2009)
Approaches to Prevent Dopamine Quinone-Induced Neurotoxicity
Ikuko Miyazaki et al.
NEUROCHEMICAL RESEARCH (2009)
Normal and mutant HTT interact to affect clinical severity and progression in Huntington disease
N. A. Aziz et al.
NEUROLOGY (2009)
Risperidone and the Treatment of Psychiatric, Motor, and Cognitive Symptoms in Huntington's Disease
Kevin Duff et al.
ANNALS OF CLINICAL PSYCHIATRY (2008)
Impairing the Mitochondrial Fission and Fusion Balance: A New Mechanism of Neurodegeneration
Andrew B. Knott et al.
MITOCHONDRIA AND OXIDATIVE STRESS IN NEURODEGENERATIVE DISORDERS (2008)
Modulation of vascular endothelial growth factor (VEGF) expression in motor neurons and its electrophysiological effects
Daniel P. McCloskey et al.
BRAIN RESEARCH BULLETIN (2008)
A study of chorea after tetrabenazine withdrawal in patients with Huntington disease
Samuel Frank et al.
CLINICAL NEUROPHARMACOLOGY (2008)
Mechanisms of neurodegeneration in Huntington's disease
Joana M. Gil et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2008)
The antidepressant sertraline improves the phenotype, promotes neurogenesis and increases BDNF levels in the R6/2 Huntington's disease mouse model
Qi Peng et al.
EXPERIMENTAL NEUROLOGY (2008)
The metabolic profile of early Huntington's disease - a combined human and transgenic mouse study
Anna O. G. Goodman et al.
EXPERIMENTAL NEUROLOGY (2008)
Identification and allele-specific silencing of the mutant huntingtin allele in Huntington's disease patient-derived fibroblasts
P. H. J. van Bilsen et al.
HUMAN GENE THERAPY (2008)
Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1
Salima Hacein-Bey-Abina et al.
JOURNAL OF CLINICAL INVESTIGATION (2008)
Full-length human mutant huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD mice
Michelle Gray et al.
JOURNAL OF NEUROSCIENCE (2008)
Long-term follow-up of Huntington disease treated by bilateral deep brain stimulation of the internal globus pallidus
Brigitte Biolsi et al.
JOURNAL OF NEUROSURGERY (2008)
The relationship between CAG repeat length and clinical progression in Huntington's disease
Bernard Ravina et al.
MOVEMENT DISORDERS (2008)
GPi-DBS in Huntington's disease: Results on motor function and cognition in a 72-year-old case
Alfonso Fasano et al.
MOVEMENT DISORDERS (2008)
Mitochondrial fragmentation in neurodegeneration
Andrew B. Knott et al.
NATURE REVIEWS NEUROSCIENCE (2008)
Sertraline slows disease progression and increases neurogenesis in N171-82Q mouse model of Huntington's disease
Wenzhen Duan et al.
NEUROBIOLOGY OF DISEASE (2008)
PROGRESSIVE SYNAPTIC PATHOLOGY OF MOTOR CORTICAL NEURONS IN A BAC TRANSGENIC MOUSE MODEL OF HUNTINGTON'S DISEASE
J. Spampanato et al.
NEUROSCIENCE (2008)
Artificial miRNAs mitigate shRNA-mediated toxicity in the brain: Implications for the therapeutic development of RNAi
Jodi L. McBride et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
The HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice
Elizabeth A. Thomas et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Systematic assessment of BDNF and its receptor levels in human cortices affected by Huntington's disease
Chiara Zuccato et al.
BRAIN PATHOLOGY (2008)
Therapeutic silencing of mutant huntingtin with siRNA attenuates striatal and cortical neuropathology and behavioral deficits
M. DiFiglia et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Induction of neostriatal neurogenesis slows disease progression in a transgenic murine model of Huntington disease
Sung-Rae Cho et al.
JOURNAL OF CLINICAL INVESTIGATION (2007)
Riluzole in Huntington's disease: A 3-year, randomized controlled study
G. Bernhard Landwehrmeyer et al.
ANNALS OF NEUROLOGY (2007)
Increased oxidative damage and mitochondrial abnormalities in the peripheral blood of Huntington's disease patients
Chiung-Mei Chen et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)
Low brain-derived neurotrophic factor (BDNF) levels in serum of Huntington's disease patients
A. Ciammola et al.
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS (2007)
Stem cells act through multiple mechanisms to benefit mice with neurodegenerative metabolic disease
Jean-Pyo Lee et al.
NATURE MEDICINE (2007)
Metformin therapy in a transgenic mouse model of Huntington's disease
Thong C. Ma et al.
NEUROSCIENCE LETTERS (2007)
High-capacity adenoviral vector-mediated reduction of Huntingtin aggregate load in vitro and in vivo
Bin Huang et al.
HUMAN GENE THERAPY (2007)
A pilot study of the clinical efficacy and safety of memantine for Huntington's disease
William G. Ondo et al.
PARKINSONISM & RELATED DISORDERS (2007)
Role of brain-derived neurotrophic factor in Huntington's disease
Chiara Zuccato et al.
PROGRESS IN NEUROBIOLOGY (2007)
Patients with Huntington's disease have impaired awareness of cognitive, emotional, and functional abilities
Karin F. Hoth et al.
JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY (2007)
Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1α in Huntington's disease neurodegeneration
Patrick Weydt et al.
CELL METABOLISM (2006)
Mitochondrial-dependent Ca2+ handling in Huntington's disease striatal cells:: Effect of histone deacetylase inhibitors
Jorge M. A. Oliveira et al.
JOURNAL OF NEUROSCIENCE (2006)
Transcriptional repression of PGC-α by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration
Libin Cui et al.
CELL (2006)
Hypothalamic-endocrine aspects in Huntington's disease
Asa Petersen et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2006)
Viral delivery of glial cell line-derived neurotrophic factor improves behavior and protects striatal neurons in a mouse model of Huntington's disease
Jodi L. McBride et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways
Dirk Grimm et al.
NATURE (2006)
Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase
M Borrell-Pagès et al.
JOURNAL OF CLINICAL INVESTIGATION (2006)
Effective gene therapy with nonintegrating lentiviral vectors
RJ Yáñez-Muñoz et al.
NATURE MEDICINE (2006)
Tetrabenazine as antichorea therapy in Huntington disease - A randomized controlled trial
FJ Marshall et al.
NEUROLOGY (2006)
Quetiapine in the treatment of behavioral disturbances in patients with Huntington's disease
M Alpay et al.
PSYCHOSOMATICS (2006)
Pharmacological management of Huntington's disease: An evidence-based review
Raphael M. Bonelli et al.
CURRENT PHARMACEUTICAL DESIGN (2006)
Differential effects of voluntary physical exercise on behavioral and brain-derived neurotrophic factor expression deficits in Huntington's disease transgenic mice
T. Y. C. Pang et al.
NEUROSCIENCE (2006)
Evaluation of the benzothiazole aggregation inhibitors riluzole and PGL-135 as therapeutics for Huntington's disease
E Hockly et al.
NEUROBIOLOGY OF DISEASE (2006)
Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity
JY Shin et al.
JOURNAL OF CELL BIOLOGY (2005)
Selective degeneration and nuclear localization of mutant huntingtin in the YAC128 mouse model of Huntington disease
JM Van Raamsdonk et al.
HUMAN MOLECULAR GENETICS (2005)
Proteomic analysis of protein expression and oxidative modification in R6/2 transgenic mice
M Perluigi et al.
MOLECULAR & CELLULAR PROTEOMICS (2005)
Normal huntingtin function: An alternative approach to Huntington's disease
E Cattaneo et al.
NATURE REVIEWS NEUROSCIENCE (2005)
Clinico-pathological rescue of a model mouse of Huntington's disease by siRNA
YL Wang et al.
NEUROSCIENCE RESEARCH (2005)
Chronology of behavioral symptoms and neuropathological sequela in R6/2 Huntington's disease transgenic mice
EC Stack et al.
JOURNAL OF COMPARATIVE NEUROLOGY (2005)
Gene therapy of storage disorders by retroviral and lentiviral vectors
A Biffi et al.
HUMAN GENE THERAPY (2005)
Cognitive disorders and neurogenesis deficits in Huntington's disease mice are rescued by fluoxetine
HE Grote et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2005)
Unraveling a role for dopamine in Huntington's disease:: The dual role of reactive oxygen species and D2 receptor stimulation
D Charvin et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin
HK Teng et al.
JOURNAL OF NEUROSCIENCE (2005)
Metabolic control through the PGC-1 family of transcription coactivators
JD Lin et al.
CELL METABOLISM (2005)
Lentiviral gene delivery of GDNF into the striatum of R6/2 Huntington mice fails to attenuate behavioral and neuropathological changes
N Popovic et al.
EXPERIMENTAL NEUROLOGY (2005)
Critical periods of suicide risk in Huntington's disease
JS Paulsen et al.
AMERICAN JOURNAL OF PSYCHIATRY (2005)
Pallidal deep brain stimulation influences both reflexive and voluntary saccades in Huntington's disease
AP Fawcett et al.
MOVEMENT DISORDERS (2005)
NR2A and NR2B receptor gene variations modify age at onset in Huntington disease
L Arning et al.
NEUROGENETICS (2005)
Orexin loss in Huntington's disease
A Petersen et al.
HUMAN MOLECULAR GENETICS (2005)
AAV-mediated gene delivery of BDNF or GDNF is neuroprotective in a model of Huntington disease
AP Kells et al.
MOLECULAR THERAPY (2004)
Early striatal dendrite deficits followed by neuron loss with advanced age in the absence of anterograde cortical brain-derived neurotrophic factor
ZC Baquet et al.
JOURNAL OF NEUROSCIENCE (2004)
Paroxetine retards disease onset and progression in huntingtin mutant mice
WZ Duan et al.
ANNALS OF NEUROLOGY (2004)
Environmental enrichment rescues protein deficits in a mouse model of Huntington's disease, indicating a possible disease mechanism
TL Spires et al.
JOURNAL OF NEUROSCIENCE (2004)
The energetics of Huntington's disease
SE Browne et al.
NEUROCHEMICAL RESEARCH (2004)
Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington disease
M Tanaka et al.
NATURE MEDICINE (2004)
Cystamine increases L-cysteine levels in Huntington's disease transgenic mouse brain and in a PC12 model of polyglutamine aggregation
JH Fox et al.
JOURNAL OF NEUROCHEMISTRY (2004)
Generalized brain and skin proteasome inhibition in Huntington's disease
H Seo et al.
ANNALS OF NEUROLOGY (2004)
Brain-derived neurotrophic factor regulates the onset and severity of motor dysfunction associated with enkephalinergic neuronal degeneration in Huntington's disease
JM Canals et al.
JOURNAL OF NEUROSCIENCE (2004)
Bilateral globus pallidus stimulation for Huntington's disease
E Moro et al.
ANNALS OF NEUROLOGY (2004)
Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules
LR Gauthier et al.
CELL (2004)
Neurotransmitters and substances of abuse: Effects on adult neurogenesis
TA Powrozek et al.
CURRENT NEUROVASCULAR RESEARCH (2004)
Effects of rivastigmine on motor and cognitive impairment in Huntington's disease
M de Tommaso et al.
MOVEMENT DISORDERS (2004)
Quetiapine in the Management of Psychosis Secondary to Huntington's Disease: A Case Report
Dallas P. Seitz et al.
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE (2004)
Proactive transplantation of human neural stem cells prevents degeneration of striatal neurons in a rat model of Huntington disease
JK Ryu et al.
NEUROBIOLOGY OF DISEASE (2004)
Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease
B Ravikumar et al.
NATURE GENETICS (2004)
Genetic mouse models of Huntington's and Parkinson's diseases: illuminating but imperfect
MS Levine et al.
TRENDS IN NEUROSCIENCES (2004)
Treatment of Huntington's disease with galantamine
P Petrikis et al.
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY (2004)
Dendritic spine pathology and deficits in experience-dependent dendritic plasticity in R6/1 Huntington's disease transgenic mice
TL Spires et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2004)
Analysis of cellular, transgenic and human models of Huntington's disease reveals tyrosine hydroxylase alterations and substantia nigra neuropathology
GJ Yohrling et al.
MOLECULAR BRAIN RESEARCH (2003)
Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease
EJ Slow et al.
HUMAN MOLECULAR GENETICS (2003)
A Randomized trial of amantadine in Huntington disease
P O'Suilleabhain et al.
ARCHIVES OF NEUROLOGY (2003)
IV amantadine improves chorea in Huntington's disease - An acute randomized, controlled study
C Lucetti et al.
NEUROLOGY (2003)
Structural and functional neuroprotection in a rat model of Huntington's disease by viral gene transfer of GDNF
JL McBride et al.
EXPERIMENTAL NEUROLOGY (2003)
Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease
SS Gill et al.
NATURE MEDICINE (2003)
Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingtin mutant mice
WZ Duan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Specific progressive cAMP reduction implicates energy deficit in presymptomatic Huntington's disease knock-in mice
S Gines et al.
HUMAN MOLECULAR GENETICS (2003)
Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease
E Hockly et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Cystamine inhibits caspase activity - Implications for the treatment of polyglutamine disorders
M Lesort et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
The use of transgenic and knock-in mice to study Huntington's disease
MA Hickey et al.
CYTOGENETIC AND GENOME RESEARCH (2003)
Rivastigmine in the treatment of Huntington's disease
U Rot et al.
EUROPEAN JOURNAL OF NEUROLOGY (2002)
Olanzapine for Huntington's disease: An open label study
RM Bonelli et al.
CLINICAL NEUROPHARMACOLOGY (2002)
Amantadine in Huntington's disease: open-label video-blinded study
C Lucetti et al.
NEUROLOGICAL SCIENCES (2002)
Modulation of DOI-induced increases in cortical BDNF expression by group II mGlu receptors
JC Gewirtz et al.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2002)
Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines
AV Panov et al.
NATURE NEUROSCIENCE (2002)
Riluzole prolongs survival time and alters nuclear inclusion formation in a transgenic mouse model of Huntington's disease
J Schiefer et al.
MOVEMENT DISORDERS (2002)
Neurotrophin signaling through the p75 neurotrophin receptor
PP Roux et al.
PROGRESS IN NEUROBIOLOGY (2002)
Olanzapine in Huntington's disease
D Paleacu et al.
ACTA NEUROLOGICA SCANDINAVICA (2002)
Opinion - Neural stem cell therapy for neurological diseases: dreams and reality
F Rossi et al.
NATURE REVIEWS NEUROSCIENCE (2002)
Regional and progressive thinning of the cortical ribbon in Huntington's disease
HD Rosas et al.
NEUROLOGY (2002)
Risperidone in chorea and psychosis of Huntington's disease
AK Erdemoglu et al.
EUROPEAN JOURNAL OF NEUROLOGY (2002)
Mouse models of Huntington's disease
LB Menalled et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2002)
Anterior cingulate cortical transplantation in transgenic Huntington's disease mice
A van Dellen et al.
BRAIN RESEARCH BULLETIN (2001)
Impaired glutamate uptake in the R6 Huntington's disease transgenic mice
JC Liévens et al.
NEUROBIOLOGY OF DISEASE (2001)
Neuropsychiatric aspects of Huntington's disease
JS Paulsen et al.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2001)
Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease
C Zuccato et al.
SCIENCE (2001)
Neuroprotective effect of a CNTF-expressing lentiviral vector in the quinolinic acid rat model of Huntington's disease
LP de Almeida et al.
NEUROBIOLOGY OF DISEASE (2001)
Open interconnected model of basal ganglia-thalamocortical circuitry and its relevance to the clinical syndrome of Huntington's disease
D Joel
MOVEMENT DISORDERS (2001)
Signal transduction pathways through TRK-A and TRK-B receptors in human neuroblastoma cells
T Sugimoto et al.
JAPANESE JOURNAL OF CANCER RESEARCH (2001)
The selective vulnerability of nerve cells in Huntington's disease
KA Sieradzan et al.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2001)
Neurological abnormalities in a knock-in mouse model of Huntington's disease
CH Lin et al.
HUMAN MOLECULAR GENETICS (2001)
Mutant huntingtin enhances excitotoxic cell death
MM Zeron et al.
MOLECULAR AND CELLULAR NEUROSCIENCE (2001)
Regulation of cell death by the Abl tyrosine kinase
JYJ Wang
ONCOGENE (2000)
Brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4/5 prevent the death of striatal projection neurons in a rodent model of Huntington's disease
E Pérez-Navarro et al.
JOURNAL OF NEUROCHEMISTRY (2000)
Chemical anatomy of striatal interneurons in normal individuals and in patients with Huntington's disease
F Cicchetti et al.
BRAIN RESEARCH REVIEWS (2000)
Brain-derived neurotrophic factor in Huntington disease
I Ferrer et al.
BRAIN RESEARCH (2000)
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