期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 22, 期 14, 页码 -出版社
MDPI
DOI: 10.3390/ijms22147381
关键词
evolution; plant science; nucleic acids; circular dichroism; UV light
资金
- University of Ostrava [SGS02/PrF/2021, SGS11/PrF/2021]
- Czech Science Foundation (GA C. R) [18-23702S]
- National Agency for Agricultural Research (NAZV) of the Czech Republic [QK1810391]
- project SustES-Adaptation strategies for sustainable ecosystem services and food security under adverse environmental conditions [CZ.02.1.01/0.0/0.0/16_019/0000797]
A stable G-quadruplex has been identified in the gene RPB1, encoding for RNA polymerase II, and is highly evolutionarily conserved among plants. A new hypothesis suggests the interaction of G-quadruplexes with UV light in plants to potentially form an additional layer of regulatory network.
G-quadruplexes have long been perceived as rare and physiologically unimportant nucleic acid structures. However, several studies have revealed their importance in molecular processes, suggesting their possible role in replication and gene expression regulation. Pathways involving G-quadruplexes are intensively studied, especially in the context of human diseases, while their involvement in gene expression regulation in plants remains largely unexplored. Here, we conducted a bioinformatic study and performed a complex circular dichroism measurement to identify a stable G-quadruplex in the gene RPB1, coding for the RNA polymerase II large subunit. We found that this G-quadruplex-forming locus is highly evolutionarily conserved amongst plants sensu lato (Archaeplastida) that share a common ancestor more than one billion years old. Finally, we discussed a new hypothesis regarding G-quadruplexes interacting with UV light in plants to potentially form an additional layer of the regulatory network.
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