4.7 Article

Novel A-Ring Chalcone Derivatives of Oleanolic and Ursolic Amides with Anti-Proliferative Effect Mediated through ROS-Triggered Apoptosis

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Chemistry, Applied

Synthesis of messagenin and platanic acid chalcone derivatives and their biological potential

Elmira Khusnutdinova et al.

Summary: Chalcone derivatives of 20-oxo-lupanes were synthesized and screened for biological activity, showing potential cytotoxic effects on cancer cell lines. The E configuration of one derivative was confirmed via X-ray analysis. Additionally, some compounds demonstrated inhibitory activity against enzymes and potential antiviral effects.

NATURAL PRODUCT RESEARCH (2022)

Article Biochemistry & Molecular Biology

Functionalization of Betulinic Acid with Polyphenolic Fragments for the Development of New Amphiphilic Antioxidants

Joana L. C. Sousa et al.

Summary: This study focused on valorizing biomass derived compounds by transforming them into new added-value compounds with enhanced antioxidant properties. Through the design of specific substitution patterns, a derivative was found to exhibit the highest scavenging ability against free radicals. Additionally, analogues were designed and tested, with one showing an increased scavenging effect due to the presence of an extended pi-conjugated system at a particular position.

ANTIOXIDANTS (2021)

Article Chemistry, Medicinal

Synthesis and antitumor potential of new arylidene ursolic acid derivatives via caspase-8 activation

Baoen He et al.

Summary: The newly synthesized NO-releasing ursolic acid-arylidene derivative compound 5c showed potent broad-spectrum antitumor activity in various tumor cell lines, especially exhibiting the strongest apoptosis-inducing effect in MCF-7 cells. Compound 5c affected cell cycle, activated caspase, decreased the Bcl-2/Bax ratio, led to changes in mitochondrial membrane potential, and accumulation of reactive oxygen species in the cells. Additionally, a docking study revealed a potential interaction between the nitroxyethyl moiety of compound 5c and caspase-8 amino acid residues.

ARCHIV DER PHARMAZIE (2021)

Article Biochemistry & Molecular Biology

Cytotoxic Potential of a-Azepano- and 3-Amino-3,4-SeCo-Triterpenoids

Oxana Kazakova et al.

Summary: In this study, a series of compounds with an amino substituted seven-membered A-ring were evaluated for their cytotoxic activity against cancer cell lines, showing high growth inhibitory and cytotoxic activity against sensitive cell lines. These compounds demonstrated potential for future development as novel antitumor agents with a certain level of selectivity.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Biochemistry & Molecular Biology

Synthesis and biological evaluation of pentacyclic triterpenoid derivatives as potential novel antibacterial agents

Panpan Wu et al.

Summary: A series of triterpenoid derivatives, including ursolic acid (UA), oleanolic acid (OA), and 18β-glycyrrhetinic acid (GA), were synthesized with various substituted aromatic side chains at the C-2 position. Among them, the GA derivative with aromatic side chains showed potent antibacterial activity against drug sensitive and resistant S. aureus, indicating potential for development of a new type of triterpenoid antibacterial agent.

BIOORGANIC CHEMISTRY (2021)

Review Biochemistry & Molecular Biology

Pentacyclic Triterpenoids with Nitrogen-Containing Heterocyclic Moiety, Privileged Hybrids in Anticancer Drug Discovery

Vuyolwethu Khwaza et al.

Summary: Pentacyclic triterpenoids are widely known plant phytochemicals with diverse biological activities, making them valuable sources for pharmacological agents. Compounds with nitrogen-containing heterocyclic scaffolds have shown great potential as candidate drugs, with about 75% of FDA-approved drugs belonging to this category. Researchers are exploring new triterpenoid derivatives with pharmacological activities, particularly those containing nitrogen-containing heterocyclic moieties.

MOLECULES (2021)

Article Chemistry, Medicinal

Synthesis and anti-cancer activity studies of dammarane-type triterpenoid derivatives

Lu Ma et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)

Article Chemistry, Medicinal

CDDO-imidazolide Targets Multiple Amino Acid Residues on the Nrf2 Adaptor, Keap1

Xiaoli Meng et al.

JOURNAL OF MEDICINAL CHEMISTRY (2020)

Editorial Material Biochemistry & Molecular Biology

Plant Natural Products for Human Health

Chun-Tao Che et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Chemistry, Medicinal

The potential of click reactions for the synthesis of bioactive triterpenes

Rene Csuk et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2019)

Article Biochemistry & Molecular Biology

Synthesis and Antitumor Evaluation in Vitro of NO-Donating Ursolic Acid-Benzylidene Derivatives

Te Zhang et al.

CHEMISTRY & BIODIVERSITY (2019)

Article Chemistry, Medicinal

Synthesis and biological evaluation of ursolic acid derivatives containing an aminoguanidine moiety

Jie Wu et al.

MEDICINAL CHEMISTRY RESEARCH (2019)

Article Plant Sciences

Madecassic Acid Derivatives as Potential Anticancer Agents: Synthesis and Cytotoxic Evaluation

Ana S. C. Valdeira et al.

JOURNAL OF NATURAL PRODUCTS (2019)

Article Chemistry, Medicinal

Ursolic acid derivative induces apoptosis in glioma cells through down-regulation of cAMP

Haitao Fan et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)

Review Chemistry, Medicinal

Design and synthesis of pentacyclic triterpene conjugates and their use in medicinal research

Jiri Hodon et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)

Review Biochemistry & Molecular Biology

Synthesis and Anticancer Activity of CDDO and CDDO-Me, Two Derivatives of Natural Triterpenoids

Rebecca Borella et al.

MOLECULES (2019)

Review Biochemistry & Molecular Biology

Known Triterpenes and their Derivatives as Scaffolds for the Development of New Therapeutic Agents for Cancer

Gregorio Peron et al.

CURRENT MEDICINAL CHEMISTRY (2018)

Article Biochemistry & Molecular Biology

The Synthesis and Selective Cytotoxicity of New Mannich Bases, Derivatives of 19-and 28-Alkynyltriterpenoids

E. F. Khusnutdinova et al.

RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY (2018)

Article Chemistry, Multidisciplinary

ADMETlab: a platform for systematic ADMET evaluation based on a comprehensively collected ADMET database

Jie Dong et al.

JOURNAL OF CHEMINFORMATICS (2018)

Article Chemistry, Multidisciplinary

Synthesis and Biological Evaluation of New Madecassic Acid Derivatives Targeting ERK Cascade Signaling

Ana S. C. Valdeira et al.

FRONTIERS IN CHEMISTRY (2018)

Article Chemistry, Medicinal

Synthesis of novel benzylidene analogues of betulinic acid as potent cytotoxic agents

Nidhi Gupta et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2017)

Review Chemistry, Medicinal

Oleanane-, ursane-, and quinone methide friedelane-type triterpenoid derivatives: Recent advances in cancer treatment

Jorge A. R. Salvador et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2017)

Review Biochemistry & Molecular Biology

Histone Deacetylase Inhibitors as Anticancer Drugs

Tomas Eckschlager et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Article Chemistry, Medicinal

Synthesis and evaluation of 2,3-indolotriterpenoids as new α-glucosidase inhibitors

Elmira F. Khusnutdinova et al.

MEDICINAL CHEMISTRY RESEARCH (2017)

Article Chemistry, Medicinal

Data Warrior: An Open-Source Program For Chemistry Aware Data Visualization And Analysis

Thomas Sander et al.

JOURNAL OF CHEMICAL INFORMATION AND MODELING (2015)

Article Cell Biology

Cell Death Signaling

Douglas R. Green et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2015)

Article Chemistry, Medicinal

Synthesis and in vitro anticancer studies of novel C-2 arylidene congeners of lantadenes

Navin K. Tailor et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2013)

Article Plant Sciences

Synthesis and alpha-glucosidase inhibitory activity of oleanolic acid derivatives

Shan Qian et al.

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH (2010)

Article Biochemistry & Molecular Biology

Synthesis of triterpenoid acylates: Effective reproduction inhibitors of influenza A (H1N1) and papilloma viruses

O. B. Kazakova et al.

RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY (2010)

Article Biochemistry & Molecular Biology

Synthesis, modification, and antimicrobial activity of the N-methylpiperazinyl amides of triterpenic acids

O. B. Kazakova et al.

RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY (2010)

Article Biotechnology & Applied Microbiology

Comprehensive characterization of cytochrome P450 isozyme selectivity across chemical libraries

Henrike Veith et al.

NATURE BIOTECHNOLOGY (2009)

Article Chemistry, Medicinal

Structure-dependent inhibition of bladder and pancreatic cancer cell growth by 2-substituted glycyrrhetinic and ursolic acid derivatives

Gayathri Chadalapaka et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)

Article Biochemistry & Molecular Biology

Cytotoxic and genotoxic effects of tambjamine D, an alkaloid isolated from the nudibranch Tambja eliora, on Chinese hamster lung fibroblasts

Bruno C. Cavalcanti et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2008)

Article Oncology

The NCI60 human tumour cell line anticancer drug screen

Robert H. Shoemaker

NATURE REVIEWS CANCER (2006)

Article Chemistry, Medicinal

Medicinal chemistry of hERG optimizations: Highlights and hang-ups

Craig Jamieson et al.

JOURNAL OF MEDICINAL CHEMISTRY (2006)