期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 22, 期 17, 页码 -出版社
MDPI
DOI: 10.3390/ijms22179585
关键词
Mdm2-p53; plasma treatment; molecular dynamic (MD) simulations
资金
- R3QR Program (Qdai-jump Research Program) [01257]
- JSPS-KAKENHI [21H01074, 21H04451, 19H05462, 20K14454, 20H01893]
- Plasma Bio Consortium, Center for Low-Temperature Plasma Sciences, Nagoya University
- Grants-in-Aid for Scientific Research [20K14454, 20H01893, 21H01074, 21H04451] Funding Source: KAKEN
This study investigated the impact of plasma treatment on Mdm2 and p53 through MD simulations, revealing that oxidized Mdm2 showed increased flexibility in bound or unbound states, potentially enhancing the availability of tumor suppressor protein p53 in plasma-treated cells. This insight into Mdm2 and p53 contributes to a better understanding of plasma oncology.
The study of protein-protein interactions is of great interest. Several early studies focused on the murine double minute 2 (Mdm2)-tumor suppressor protein p53 interactions. However, the effect of plasma treatment on Mdm2 and p53 is still absent from the literature. This study investigated the structural changes in Mdm2, p53, and the Mdm2-p53 complex before and after possible plasma oxidation through molecular dynamic (MD) simulations. MD calculation revealed that the oxidized Mdm2 bounded or unbounded showed high flexibility that might increase the availability of tumor suppressor protein p53 in plasma-treated cells. This study provides insight into Mdm2 and p53 for a better understanding of plasma oncology.
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