期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 22, 期 17, 页码 -出版社
MDPI
DOI: 10.3390/ijms22179615
关键词
megakaryocyte; platelet; transcription factor; differentiation; disease; ageing
资金
- National Research Foundation of Korea (NRF) - Korea government (MSIT) [2021R1C1C1011899]
- KRIBB Research Initiative Program [KGM5362111, KGM5502113]
- National Research Foundation of Korea [2021R1C1C1011899] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Platelets, small anucleate blood cells critical in hemostasis, are produced by megakaryocytes from hematopoietic stem cells. Understanding key transcription factors is crucial for platelet biogenesis, as mutations can lead to disorders such as thrombocytopenia. Metabolic changes and diseases like cancer can also impact platelet production.
Platelets play a critical role in hemostasis and thrombus formation. Platelets are small, anucleate, and short-lived blood cells that are produced by the large, polyploid, and hematopoietic stem cell (HSC)-derived megakaryocytes in bone marrow. Approximately 3000 platelets are released from one megakaryocyte, and thus, it is important to understand the physiologically relevant mechanism of development of mature megakaryocytes. Many genes, including several key transcription factors, have been shown to be crucial for platelet biogenesis. Mutations in these genes can perturb megakaryopoiesis or thrombopoiesis, resulting in thrombocytopenia. Metabolic changes owing to inflammation, ageing, or diseases such as cancer, in which platelets play crucial roles in disease development, can also affect platelet biogenesis. In this review, I describe the characteristics of platelets and megakaryocytes in terms of their differentiation processes. The role of several critical transcription factors have been discussed to better understand the changes in platelet biogenesis that occur during disease or ageing.
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