期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 22, 期 11, 页码 -出版社
MDPI
DOI: 10.3390/ijms22115421
关键词
inflammation; cancer; metastasis; tumor microenvironment; immunosuppression
资金
- JSPS KAKENHI [JP 15K21775, JP 20H03758, JP 19J00887, JP 19K16736, JP 19J11357, JP 19J00502, JP 19K09198, JP 20H03531]
- AMED (PRIME) [JP 18gm6210008/19gm6210008/20gm6210008/21gm6210008]
- JST FOREST Program
- Keio Gijuku Academic Development Funds
- Uehara Memorial Foundation
- Kanae Foundation for the Promotion of Medical Science
- Astellas Foundation for Research on Metabolic Disorders
- SENSHIN Medical Research Foundation
- Bristol Myers Squibb
- SGH foundation
- MSD Life Science Foundation
- Ichiro Kanehara Foundation for the Promotion of Medical Sciences and Medical Care
- Yasuda Medical Foundation
- Suzuken Memorial Foundation
- Pancreas Research Foundation of Japan
- Japanese Foundation for Multidisciplinary Treatment of Cancer, Project Mirai Cancer Research Grants from the Japan Cancer Society
- Okinaka Memorial Institute for Medical Research
- Asahi Glass Foundation
- Foundation for Promotion of Cancer Research
- Kobayashi Foundation for Cancer Research
- Toray Science Foundation
- Vehicle Racing Commemorative Foundation
- Public Trust Surgery Research Fund
- Princess Takamatsu Cancer Research Fund
- Tokyo Biomedical Foundation
- Daiichi Sankyo Foundation of Life Science
- Mochida Memorial Foundation for Medical and Pharmaceutical Research
- Medical Research Encouragement Prize of the Japan Medical Association
- Terumo Foundation for Life Sciences and Arts
- Novartis Foundation
- Mitsubishi Foundation
- Takeda Science Foundation
- Kowa Life Science Foundation
- YakultBioscience Foundation
- Waksman Foundation of Japan Inc.
Inflammation plays a pivotal role in tumorigenesis and metastasis by suppressing anti-tumor immunity. Different types of tumors may have diverse responses to inflammation.
Inflammation, especially chronic inflammation, plays a pivotal role in tumorigenesis and metastasis through various mechanisms and is now recognized as a hallmark of cancer and an attractive therapeutic target in cancer. In this review, we discuss recent advances in molecular mechanisms of how inflammation promotes tumorigenesis and metastasis and suppresses anti-tumor immunity in various types of solid tumors, including esophageal, gastric, colorectal, liver, and pancreatic cancer as well as hematopoietic malignancies.
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