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JOURNAL OF MOLECULAR NEUROSCIENCE (2015)
Inhibition of Neuronal p38α, but not p38β MAPK, Provides Neuroprotection Against Three Different Neurotoxic Insults
Bin Xing et al.
JOURNAL OF MOLECULAR NEUROSCIENCE (2015)
Anti-Diabetes Drug Pioglitazone Ameliorates Synaptic Defects in AD Transgenic Mice by Inhibiting Cyclin-Dependent Kinase5 Activity
Jinan Chen et al.
PLOS ONE (2015)
Enhancement of BACE1 Activity by p25/Cdk5-Mediated Phosphorylation in Alzheimer's Disease
Woo-Joo Song et al.
PLOS ONE (2015)
A Phase II Trial of Tideglusib in Alzheimer's Disease
Simon Lovestone et al.
JOURNAL OF ALZHEIMERS DISEASE (2015)
Selective Brain-Targeted Antagonism of p38 MAPKα Reduces Hippocampal IL-1β Levels and Improves Morris Water Maze Performance in Aged Rats
John J. Alam
JOURNAL OF ALZHEIMERS DISEASE (2015)
Activation of mTOR: a culprit of Alzheimer's disease?
Zhiyou Cai et al.
NEUROPSYCHIATRIC DISEASE AND TREATMENT (2015)
Mechanisms of synaptic dysfunction and excitotoxicity in Huntington's disease
Marja D. Sepers et al.
DRUG DISCOVERY TODAY (2014)
Antisense oligonucleotide against GSK-3β in brain of SAMP8 mice improves learning and memory and decreases oxidative stress: Involvement of transcription factor Nrf2 and implications for Alzheimer disease
Susan A. Farr et al.
FREE RADICAL BIOLOGY AND MEDICINE (2014)
Dynamic Range of GSK3α Not GSK3β Is Essential For Bidirectional Synaptic Plasticity at Hippocampal CA3-CA1 Synapses
Lion Shahab et al.
HIPPOCAMPUS (2014)
Regional Differences in White Matter Breakdown Between Frontotemporal Dementia and Early-Onset Alzheimer's Disease
Po H. Lu et al.
JOURNAL OF ALZHEIMERS DISEASE (2014)
Structural basis of valmerins as dual inhibitors of GSK3β/CDK5
Xiaolong Li et al.
JOURNAL OF MOLECULAR MODELING (2014)
Alterations in STriatal-Enriched protein tyrosine Phosphatase expression, activation, and downstream signaling in early and late stages of the YAC128 Huntington's disease mouse model
Clare M. Gladding et al.
JOURNAL OF NEUROCHEMISTRY (2014)
Mutant Huntingtin Affects Cortical Progenitor Cell Division and Development of the Mouse Neocortex
Maria Molina-Calavita et al.
JOURNAL OF NEUROSCIENCE (2014)
Huntington's disease is a four-repeat tauopathy with tau nuclear rods
Marta Fernandez-Nogales et al.
NATURE MEDICINE (2014)
Expression, pharmacology and functional activity of adenosine A1 receptors in genetic models of Huntington's disease
Antonella Ferrante et al.
NEUROBIOLOGY OF DISEASE (2014)
CDK5 activator protein p25 preferentially binds and activates GSK3β
Hei-Man Chow et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Generation of the Cdk5 activator p25 is a memory mechanism that is affected in early Alzheimer's disease
K. Peter Giese
FRONTIERS IN MOLECULAR NEUROSCIENCE (2014)
Physiological and pathological phosphorylation of tau by Cdk5
Taeko Kimura et al.
FRONTIERS IN MOLECULAR NEUROSCIENCE (2014)
mTOR regulates tau phosphorylation and degradation: implications for Alzheimer's disease and other tauopathies
Antonella Caccamo et al.
AGING CELL (2013)
Reduction of Hippocampal Apoptosis by Intracerebroventricular Administration of Extracellular Signal-Regulated Protein Kinase and/or p38 Inhibitors in Amyloid Beta Rat Model of Alzheimer's Disease: Involvement of Nuclear-Related Factor-2 and Nuclear Factor-κB
Ghorbangol Ashabi et al.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2013)
ARTD10 substrate identification on protein microarrays: regulation of GSK3β by mono-ADP-ribosylation
Karla L. H. Feijs et al.
CELL COMMUNICATION AND SIGNALING (2013)
Post-mitotic role of the cell cycle machinery
Karl Herrup
CURRENT OPINION IN CELL BIOLOGY (2013)
Cdks, cyclins and CKIs: roles beyond cell cycle regulation
Shuhui Lim et al.
DEVELOPMENT (2013)
A truncated peptide from p35, a Cdk5 activator, prevents Alzheimer's disease phenotypes in model mice
Varsha Shukla et al.
FASEB JOURNAL (2013)
Sirt1 inhibits the transcription factor CREB to regulate pituitary growth hormone synthesis
Jose Monteserin-Garcia et al.
FASEB JOURNAL (2013)
Extra-cell cycle regulatory functions of cyclin-dependent kinases (CDK) and CDK inhibitor proteins contribute to brain development and neurological disorders
Takeshi Kawauchi et al.
GENES TO CELLS (2013)
A critical role of astrocyte-mediated nuclear factor-κB-dependent inflammation in Huntington's disease
Han-Yun Hsiao et al.
HUMAN MOLECULAR GENETICS (2013)
Treatment of Alzheimer's Disease with the GSK-3 Inhibitor Tideglusib: A Pilot Study
Teodoro del Ser et al.
JOURNAL OF ALZHEIMERS DISEASE (2013)
Synapse Stability in the Precuneus Early in the Progression of Alzheimer's Disease
Stephen W. Scheff et al.
JOURNAL OF ALZHEIMERS DISEASE (2013)
Amyloid-β signals through tau to drive ectopic neuronal cell cycle re-entry in Alzheimer's disease
Matthew E. Seward et al.
JOURNAL OF CELL SCIENCE (2013)
Inhibition of GSK3 beta-mediated BACE1 expression reduces Alzheimer-associated phenotypes
Philip T. T. Ly et al.
JOURNAL OF CLINICAL INVESTIGATION (2013)
Inhibition of mitochondrial fragmentation diminishes Huntington's disease-associated neurodegeneration
Xing Guo et al.
JOURNAL OF CLINICAL INVESTIGATION (2013)
GSK-3α is a central regulator of age-related pathologies in mice
Jibin Zhou et al.
JOURNAL OF CLINICAL INVESTIGATION (2013)
AZD1080, a novel GSK3 inhibitor, rescues synaptic plasticity deficits in rodent brain and exhibits peripheral target engagement in humans
Biljana Georgievska et al.
JOURNAL OF NEUROCHEMISTRY (2013)
MAP Kinase Phosphatase 1 (MKP-1/DUSP1) Is Neuroprotective in Huntington's Disease via Additive Effects of JNK and p38 Inhibition
David M. Taylor et al.
JOURNAL OF NEUROSCIENCE (2013)
Disassociation of Histone Deacetylase-3 from Normal Huntingtin Underlies Mutant Huntingtin Neurotoxicity
Farah H. Bardai et al.
JOURNAL OF NEUROSCIENCE (2013)
Specific Inhibition of p25/Cdk5 Activity by the Cdk5 Inhibitory Peptide Reduces Neurodegeneration In Vivo
Jeyapriya Raja Sundaram et al.
JOURNAL OF NEUROSCIENCE (2013)
Macrodomain-containing proteins are new mono-ADP-ribosylhydrolases
Florian Rosenthal et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2013)
PI3 k/akt inhibition induces apoptosis through p38 activation in neurons
Aurelio Vazquez de la Torre et al.
PHARMACOLOGICAL RESEARCH (2013)
Dysregulation of PAD4-mediated citrullination of nuclear GSK3β activates TGF-β signaling and induces epithelial-to-mesenchymal transition in breast cancer cells
Sonja C. Stadler et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Impaired autophagy and APP processing in Alzheimer's disease: The potential role of Beclin 1 interactome
Antero Salminen et al.
PROGRESS IN NEUROBIOLOGY (2013)
Cell Cycle Regulation During Neurogenesis in the Embryonic and Adult Brain
Arquimedes Cheffer et al.
STEM CELL REVIEWS AND REPORTS (2013)
Huntington's disease: underlying molecular mechanisms and emerging concepts
John Labbadia et al.
TRENDS IN BIOCHEMICAL SCIENCES (2013)
Cell cycle control across the eukaryotic kingdom
Hirofumi Harashima et al.
TRENDS IN CELL BIOLOGY (2013)
Soluble forms of polyQ-expanded huntingtin rather than large aggregates cause endoplasmic reticulum stress
Julia Leitman et al.
NATURE COMMUNICATIONS (2013)
Glycogen Synthase Kinase 3 Inhibition Promotes Adult Hippocampal Neurogenesis in Vitro and in Vivo
Jose A. Morales-Garcia et al.
ACS CHEMICAL NEUROSCIENCE (2012)
Multitargeted drug development: Discovery and profiling of dihydroxy substituted 1-aza-9-oxafluorenes as lead compounds targeting Alzheimer disease relevant kinases
Volkmar Tell et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)
Glycogen synthase kinase 3β inhibitors protect hippocampal neurons from radiation-induced apoptosis by regulating MDM2-p53 pathway
D. K. Thotala et al.
CELL DEATH AND DIFFERENTIATION (2012)
Cyclin-dependent kinase Inhibitors Inspired by Roscovitine: Purine Bioisosteres
Radek Jorda et al.
CURRENT PHARMACEUTICAL DESIGN (2012)
Increased NF-κB signalling up-regulates BACE1 expression and its therapeutic potential in Alzheimer's disease
Chia-Hsiung Chen et al.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY (2012)
Identification of Novel Potentially Toxic Oligomers Formed in Vitro from Mammalian-derived Expanded huntingtin Exon-1 Protein
Leslie G. Nucifora et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Stable Mutated tau441 Transfected SH-SY5Y Cells as Screening Tool for Alzheimer's Disease Drug Candidates
Tina Loeffler et al.
JOURNAL OF MOLECULAR NEUROSCIENCE (2012)
Gain of function by phosphorylation in Presenilin 1-mediated regulation of insulin signaling
Masato Maesako et al.
JOURNAL OF NEUROCHEMISTRY (2012)
Cdk5/p25-Induced Cytosolic PLA2-Mediated Lysophosphatidylcholine Production Regulates Neuroinflammation and Triggers Neurodegeneration
Jeyapriya R. Sundaram et al.
JOURNAL OF NEUROSCIENCE (2012)
Glycogen Synthase Kinase 3 Inhibition Promotes Lysosomal Biogenesis and Autophagic Degradation of the Amyloid-β Precursor Protein
Callum Parr et al.
MOLECULAR AND CELLULAR BIOLOGY (2012)
Combinatorial drug therapy for cancer in the post-genomic era
Bissan Al-Lazikani et al.
NATURE BIOTECHNOLOGY (2012)
Histone deacetylase (HDAC) inhibitors targeting HDAC3 and HDAC1 ameliorate polyglutamine-elicited phenotypes in model systems of Huntington's disease
Haiqun Jia et al.
NEUROBIOLOGY OF DISEASE (2012)
P38 MAPK is involved in enhanced NMDA receptor-dependent excitotoxicity in YAC transgenic mouse model of Huntington disease
Jing Fan et al.
NEUROBIOLOGY OF DISEASE (2012)
Behavioural state differentially engages septohippocampal cholinergic and GABAergic neurons in R6/1 Huntington's disease mice
Mark I. Ransome et al.
NEUROBIOLOGY OF LEARNING AND MEMORY (2012)
Depressive Symptom Severity Is Related to Poorer Cognitive Performance in Prodromal Huntington Disease
Megan M. Smith et al.
NEUROPSYCHOLOGY (2012)
Cell Cycle Proteins in Brain in Mild Cognitive Impairment: Insights into Progression to Alzheimer Disease
Jeriel T. R. Keeney et al.
NEUROTOXICITY RESEARCH (2012)
Role of Cell Cycle Re-Entry in Neurons: A Common Apoptotic Mechanism of Neuronal Cell Death
Jaume Folch et al.
NEUROTOXICITY RESEARCH (2012)
Inhibition of E2F1/CDK1 Pathway Attenuates Neuronal Apoptosis In Vitro and Confers Neuroprotection after Spinal Cord Injury In Vivo
Junfang Wu et al.
PLOS ONE (2012)
Tau as a therapeutic target in neurodegenerative disease
Diana S. Himmelstein et al.
PHARMACOLOGY & THERAPEUTICS (2012)
Alzheimer Disease in 2020
David M. Holtzman et al.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)
Hippocampal Neurogenesis, Cognitive Deficits and Affective Disorder in Huntington's Disease
Mark I. Ransome et al.
NEURAL PLASTICITY (2012)
AKT/GSK3 signaling pathway and schizophrenia
Effat S. Emamian
FRONTIERS IN MOLECULAR NEUROSCIENCE (2012)
A pivotal role of GSK-3 in synaptic plasticity
Clarrisa A. Bradley et al.
FRONTIERS IN MOLECULAR NEUROSCIENCE (2012)
Decreasing Levels of the cdk5 Activators, p25 and p35, Reduces Excitotoxicity in Striatal Neurons
Kevin H. J. Park et al.
JOURNAL OF HUNTINGTONS DISEASE (2012)
Inhibition of Polo-like kinase 1 reduces beta-amyloid-induced neuronal cell death in Alzheimer's disease
Bing Song et al.
AGING-US (2011)
Cyclin-Dependent Kinases in Brain Development and Disease
Susan C. Su et al.
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 27 (2011)
Disease-modifying properties of long-term lithium treatment for amnestic mild cognitive impairment: randomised controlled trial
Orestes V. Forlenza et al.
BRITISH JOURNAL OF PSYCHIATRY (2011)
Overcoming Hypoxia-Induced Apoptotic Resistance through Combinatorial Inhibition of GSK-3β and CDK1
Patrick A. Mayes et al.
CANCER RESEARCH (2011)
Cyclin E Constrains Cdk5 Activity to Regulate Synaptic Plasticity and Memory Formation
Junko Odajima et al.
DEVELOPMENTAL CELL (2011)
An Alzheimer's Disease-Relevant Presenilin-1 Mutation Augments Amyloid-Beta-Induced Oligodendrocyte Dysfunction
Maya K. Desai et al.
GLIA (2011)
Reactive oxygen species participate in the p38-mediated apoptosis induced by potassium deprivation and staurosporine in cerebellar granule neurons
Yazmin Ramiro-Cortes et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2011)
Selective Toxicity by HDAC3 in Neurons: Regulation by Akt and GSK3β
Farah H. Bardai et al.
JOURNAL OF NEUROSCIENCE (2011)
Nuclear envelope dispersion triggered by deregulated Cdk5 precedes neuronal death
Kuei-Hua Chang et al.
MOLECULAR BIOLOGY OF THE CELL (2011)
Neuropathologically defined subtypes of Alzheimer's disease with distinct clinical characteristics: a retrospective study
Melissa E. Murray et al.
LANCET NEUROLOGY (2011)
Microglial p38α MAPK is critical for LPS-induced neuron degeneration, through a mechanism involving TNFα
Bin Xing et al.
MOLECULAR NEURODEGENERATION (2011)
Kinase inhibitors modulate huntingtin cell localization and toxicity
Randy Singh Atwal et al.
NATURE CHEMICAL BIOLOGY (2011)
Alzheimer's disease as homeostatic responses to age-related myelin breakdown
George Bartzokis
NEUROBIOLOGY OF AGING (2011)
Impaired ATF6 alpha processing, decreased Rheb and neuronal cell cycle re-entry in Huntington's disease
Maria Rosario Fernandez-Fernandez et al.
NEUROBIOLOGY OF DISEASE (2011)
Calpain regulates N-terminal interaction of GSK-3β with 14-3-3ζ, p53 and PKB but not with axin
Paloma Goni-Oliver et al.
NEUROCHEMISTRY INTERNATIONAL (2011)
Combined Treatment with the Mood Stabilizers Lithium and Valproate Produces Multiple Beneficial Effects in Transgenic Mouse Models of Huntington's Disease
Chi-Tso Chiu et al.
NEUROPSYCHOPHARMACOLOGY (2011)
EFFECT OF GLYCOGEN SYNTHASE KINASE 3 β-MEDIATED PRESENILIN 1 PHOSPHORYLATION ON AMYLOID β PRODUCTION IS NEGATIVELY REGULATED BY INSULIN RECEPTOR CLEAVAGE
M. Maesako et al.
NEUROSCIENCE (2011)
Activation and Function of the MAPKs and Their Substrates, the MAPK-Activated Protein Kinases
Marie Cargnello et al.
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS (2011)
p38 phosphorylates Rb on Ser567 by a novel, cell cycle-independent mechanism that triggers Rb-Hdm2 interaction and apoptosis
R. B. Delston et al.
ONCOGENE (2011)
Genetic inactivation of GSK3α rescues spine deficits in Disc1-L100P mutant mice
Frankie H. F. Lee et al.
SCHIZOPHRENIA RESEARCH (2011)
Modulation of aberrant CDK5 signaling rescues impaired neurogenesis in models of Alzheimer's disease
L. Crews et al.
CELL DEATH & DISEASE (2011)
Selective Cell Death of Hyperploid Neurons in Alzheimer's Disease
Thomas Arendt et al.
AMERICAN JOURNAL OF PATHOLOGY (2010)
Longitudinal Changes in White Matter Disease and Cognition in the First Year of the Alzheimer Disease Neuroimaging Initiative
Owen Carmichael et al.
ARCHIVES OF NEUROLOGY (2010)
Mitochondria in Huntington's disease
Maria Damiano et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2010)
Study of the in vivo phosphorylation of E2F1 on Ser403
Sebastian Real et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2010)
Downregulation of NF-κB signaling by mutant huntingtin proteins induces oxidative stress and cell death
Sami Reijonen et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2010)
Pioglitazone: side effect and safety profile
Priya Shah et al.
EXPERT OPINION ON DRUG SAFETY (2010)
Role of glycogen synthase kinase-3 in Alzheimer's disease pathogenesis and glycogen synthase kinase-3 inhibitors
Jesus Avila et al.
EXPERT REVIEW OF NEUROTHERAPEUTICS (2010)
Cannabinoids Modulate Hippocampal Memory and Plasticity
Hila Abush et al.
HIPPOCAMPUS (2010)
Neuroinflammatory processes in Alzheimer's disease
Michael T. Heneka et al.
JOURNAL OF NEURAL TRANSMISSION (2010)
Mutant Huntingtin and Glycogen Synthase Kinase 3-beta Accumulate in Neuronal Lipid Rafts of a Presymptomatic Knock-In Mouse Model of Huntington's Disease
Antonio Valencia et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2010)
Identification of Novel 1,4-Benzoxazine Compounds That Are Protective in Tissue Culture and In Vivo Models of Neurodegeneration
Lulu Wang et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2010)
Negative Regulation of Vps34 by Cdk Mediated Phosphorylation
Tsuyoshi Furuya et al.
MOLECULAR CELL (2010)
Targeting Glial Cells to Elucidate the Pathogenesis of Huntington's Disease
Han-Yun Hsiao et al.
MOLECULAR NEUROBIOLOGY (2010)
Virtual Screening of Selective Multitarget Kinase Inhibitors by Combinatorial Support Vector Machines
X. H. Ma et al.
MOLECULAR PHARMACEUTICS (2010)
GSK3 signalling in neural development
Eun-Mi Hur et al.
NATURE REVIEWS NEUROSCIENCE (2010)
Mild cognitive impairment in prediagnosed Huntington disease
K. Duff et al.
NEUROLOGY (2010)
Regulation of Tau Pathology by the Microglial Fractalkine Receptor
Kiran Bhaskar et al.
NEURON (2010)
Review: Cell cycle aberrations and neurodegeneration
D. J. Bonda et al.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2010)
Inhibition of GSK-3 Ameliorates Aβ Pathology in an Adult-Onset Drosophila Model of Alzheimer's Disease
Oyinkan Sofola et al.
PLOS GENETICS (2010)
Recent advances in understanding the roles of Cdk5 in synaptic plasticity
Kwok-On Lai et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2009)
Glycogen synthase kinase-3β is activated by matrix metalloproteinase-2 mediated proteolysis in cardiomyoblasts
Arulmozhi D. Kandasamy et al.
CARDIOVASCULAR RESEARCH (2009)
Reduced amyloidogenic processing of the amyloid β-protein precursor by the small-molecule Differentiation Inducing Factor-1
Michael A. Myre et al.
CELLULAR SIGNALLING (2009)
Glycogen synthase kinase-3 regulates microglial migration, inflammation, and inflammation-induced neurotoxicity
Christopher J. Yuskaitis et al.
CELLULAR SIGNALLING (2009)
A putative role for cell cycle-related proteins in microtubule-based neuroplasticity
Stefanie Schmetsdorf et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2009)
Activation of Cell Cycle Proteins in Transgenic Mice in Response to Neuronal Loss but not Amyloid-beta and Tau Pathology
Joao P. Lopes et al.
JOURNAL OF ALZHEIMERS DISEASE (2009)
Unique and Overlapping Functions of GSK-3 Isoforms in Cell Differentiation and Proliferation and Cardiovascular Development
Thomas Force et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Phosphorylation of Threonine 3 IMPLICATIONS FOR HUNTINGTIN AGGREGATION AND NEUROTOXICITY
Charity T. Aiken et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome
Leslie Michels Thompson et al.
JOURNAL OF CELL BIOLOGY (2009)
N-cadherin-based adhesion enhances A beta release and decreases A beta(42/40) ratio
Kengo Uemura et al.
JOURNAL OF NEUROCHEMISTRY (2009)
Age-Dependent Impairment of Cognitive and Synaptic Function in the htau Mouse Model of Tau Pathology
Manuela Polydoro et al.
JOURNAL OF NEUROSCIENCE (2009)
Calpain-Mediated Truncation of GSK-3 in Post-Mortem Brain Samples
Paloma Goni-Oliver et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2009)
The PI3K-Akt-mTOR pathway regulates Aβ oligomer induced neuronal cell cycle events
Kiran Bhaskar et al.
MOLECULAR NEURODEGENERATION (2009)
Cyclin-dependent kinases: a family portrait
Marcos Malumbres et al.
NATURE CELL BIOLOGY (2009)
A novel GSK-3 beta inhibitor reduces Alzheimer's pathology and rescues neuronal loss in vivo
L. Sereno et al.
NEUROBIOLOGY OF DISEASE (2009)
GSK3 inhibitors show benefits in an Alzheimer's disease (AD) model of neurodegeneration but adverse effects in control animals
Shuxin Hu et al.
NEUROBIOLOGY OF DISEASE (2009)
Cell cycle re-entry mediated neurodegeneration and its treatment role in the pathogenesis of Alzheimer's disease
Hyoung-gon Lee et al.
NEUROCHEMISTRY INTERNATIONAL (2009)
Serines 13 and 16 Are Critical Determinants of Full-Length Human Mutant Huntingtin Induced Disease Pathogenesis in HD Mice
Xiaofeng Gu et al.
NEURON (2009)
p38MAPK: stress responses from molecular mechanisms to therapeutics
Lydia R. Coulthard et al.
TRENDS IN MOLECULAR MEDICINE (2009)
Abnormalities in brain structure and behavior in GSK-3alpha mutant mice
Oksana Kaidanovich-Beilin et al.
MOLECULAR BRAIN (2009)
Lithium Treatment and Risk of Dementia
Lars Vedel Kessing et al.
ARCHIVES OF GENERAL PSYCHIATRY (2008)
Different fibrillar Aβ 1-42 concentrations induce adult hippocampal neurons to reenter various phases of the cell cycle
Shohreh Majd et al.
BRAIN RESEARCH (2008)
The role of GSK-3 in synaptic plasticity
S. Peineau et al.
BRITISH JOURNAL OF PHARMACOLOGY (2008)
Novel 9-oxo-thiazolo[5,4-f]quinazoline-2-carbonitrile derivatives as dual cyclin-dependent kinase 1 (CDK1)/glycogen synthase kinase-3 (GSK-3) inhibitors:: Synthesis, biological evaluation and molecular modeling studies
Cedric Loge et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2008)
A chemical compound commonly used to inhibit PKR, {8-(imidazol-4-ylmethylene)-6H-azolidino[5,4-g] benzothiazol-7-one}, protects neurons by inhibiting cyclin-dependent kinase
Hsin-Mei Chen et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2008)
Mechanisms of neurodegeneration in Huntington's disease
Joana M. Gil et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2008)
The role of glycogen synthase kinase 3 in the early stages of Alzheimers' disease
Felix Hernandez et al.
FEBS LETTERS (2008)
Long-term potentiation inhibition by low-level N-methyl-D-aspartate receptor activation involves calcineurin, nitric oxide, and p38 mitogen-activated protein kinase
Yukitoshi Izumi et al.
HIPPOCAMPUS (2008)
Cell cycle activation in striatal neurons from Huntington's disease patients and rats treated with 3-nitropropionic acid
Carme Pelegri et al.
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE (2008)
A feasibility and tolerability study of lithium in Alzheimer's disease
Alastair Macdonald et al.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY (2008)
Differential involvement of cell cycle reactivation between striatal and cortical neurons in cell death induced by 3-nitropropionic acid
Hiroki Akashiba et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Deletion of GSK-3β in mice leads to hypertrophic cardiomyopathy secondary to cardiomyoblast hyperproliferation
Risto Kerkela et al.
JOURNAL OF CLINICAL INVESTIGATION (2008)
A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease
Maria Bjorkqvist et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2008)
Roscovitine-derived, dual-specificity inhibitors of cyclin-dependent kinases and casein kinases 1
Nassima Oumata et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
Suppression of mutant huntingtin aggregate formation by Cdk5/p35 through the effect on microtubule stability
Sayuko Kaminosono et al.
JOURNAL OF NEUROSCIENCE (2008)
Dopaminergic and glutamatergic signaling crosstalk in Huntington's disease neurodegeneration:: The role of p25/cyclin-dependent kinase 5
Paola Paoletti et al.
JOURNAL OF NEUROSCIENCE (2008)
Interplay between cyclin-dependent kinase 5 and glycogen synthase kinase 3β mediated by neuregulin signaling leads to differential effects on tau phosphorylation and amyloid precursor protein processing
Yi Wen et al.
JOURNAL OF NEUROSCIENCE (2008)
Receptor for advanced glycation end product-dependent activation of p38 mitogen-activated protein kinase contributes to amyloid-β-mediated cortical synaptic dysfunction
Nicola Origlia et al.
JOURNAL OF NEUROSCIENCE (2008)
Aβ Oligomers Induce Neuronal Cell Cycle Events in Alzheimer's Disease
Nicholas H. Varvel et al.
JOURNAL OF NEUROSCIENCE (2008)
Co-activation of p38 mitogen-activated protein kinase and protein tyrosine phosphatase underlies metabotropic glutamate receptor-dependent long-term depression
Peter R. Moult et al.
JOURNAL OF PHYSIOLOGY-LONDON (2008)
A Sequel to the Tale of p25/Cdk5 in Neurodegeneration
Burcin Ikiz et al.
NEURON (2008)
Deregulation of HDAC1 by p25/Cdk5 in Neurotoxicity
Dohoon Kim et al.
NEURON (2008)
A rational mechanism for combination treatment of Huntington's disease using lithium and rapamycin
Sovan Sarkar et al.
HUMAN MOLECULAR GENETICS (2008)
Nucleocytoplasmic trafficking and transcription effects of huntingtin in Huntington's disease
Ray Truant et al.
PROGRESS IN NEUROBIOLOGY (2007)
Efficacy of small-molecule glycogen synthase kinase-3 inhibitors in the postnatal rat model of tau hyperphosphorylation
M-L Selenica et al.
BRITISH JOURNAL OF PHARMACOLOGY (2007)
Novel p38α MAPK inhibitor suppresses brain proinflammatory cytokine up-regulation and attenuates synaptic dysfunction and behavioral deficits in an Alzheimer's disease mouse model
Lenka Munoz et al.
JOURNAL OF NEUROINFLAMMATION (2007)
Apoptotic action of E2F1 requires glycogen synthase kinase 3-β activity in PC12 cells
Lilia Espada et al.
JOURNAL OF NEUROCHEMISTRY (2007)
N-terminal cleavage of GSK-3 by calpain -: A new form of GSK-3 regulation
Paloma Goni-Oliver et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Glycogen synthase kinase-3 is involved in the regulation of the cell cycle in cerebellar granule cells
M. Yeste-Velasco et al.
NEUROPHARMACOLOGY (2007)
Implication of the transcription factor E2F-1 in the modulation of neuronal apoptosis
Ester Verdaguer et al.
BIOMEDICINE & PHARMACOTHERAPY (2007)
P38 MAP-Kinases pathway regulation, function and role in human diseases
Ana Cuenda et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2007)
Dopaminergic signaling and striatal neurodegeneration in Huntington's disease
Tie-Shan Tang et al.
JOURNAL OF NEUROSCIENCE (2007)
Phosphorylation of huntingtin by cyclin-dependent kinase 5 is induced by DNA damage and regulates wild-type and mutant huntingtin toxicity in neurons
Sandrine L. Anne et al.
JOURNAL OF NEUROSCIENCE (2007)
Microglial activation in presymptomatic Huntington's disease gene carriers
Yen F. Tai et al.
BRAIN (2007)
Systematic discovery of in vivo phosphorylation networks
Rune Linding et al.
CELL (2007)
3-Nitropropionic acid activates calpain/cdk5 pathway in rat striatum
Natalia Crespo-Biel et al.
NEUROSCIENCE LETTERS (2007)
Identification of Potential Therapeutic Drugs for Huntington's Disease using Caenorhabditis elegans
Cindy Voisine et al.
PLOS ONE (2007)
Differential regulation and properties of MAPKs
M. Raman et al.
ONCOGENE (2007)
Imaging microglial activation in Huntington's disease
Yen F. Tai et al.
BRAIN RESEARCH BULLETIN (2007)
TAO kinases mediate activation of p38 in response to DNA damage
Malavika Raman et al.
EMBO JOURNAL (2007)
Regional expression of key cell cycle proteins in brain from subjects with amnestic mild cognitive impairment
Rukhsana Sultana et al.
NEUROCHEMICAL RESEARCH (2007)
UP inhibits LTD in the hippocampus via regulation of GSK3β
Stephane Peineau et al.
NEURON (2007)
Neuroprotective effects of regulators of the glycogen synthase kinase-3β signaling pathway in a transgenic model of Alzheimer's disease are associated with reduced amyloid precursor protein phosphorylation
Edward Rockenstein et al.
JOURNAL OF NEUROSCIENCE (2007)
Rho mediates calcium-dependent activation of p38 alpha and subsequent excitotoxic cell death
Maria M. Semenova et al.
NATURE NEUROSCIENCE (2007)
Glycogen synthase kinase-3 inhibition is integral to long-term potentiation
Claudie Hooper et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2007)
Glycogen synthase kinase-3 (GSK3): Inflammation, diseases, and therapeutics
Richard S. Jope et al.
NEUROCHEMICAL RESEARCH (2007)
AMPAR removal underlies Aβ-induced synaptic depression and dendritic spine loss
Helen Hsieh et al.
NEURON (2006)
Glycogen synthase kinase-3 - An overview of an over-achieving protein kinase
Lisa Kockeritz et al.
CURRENT DRUG TARGETS (2006)
Sequential phosphorylation of tau protein by cAMP-dependent protein kinase and SAPK4/p38δ or JNK2 in the presence of heparin generates the AT100 epitope
Hirotaka Yoshida et al.
JOURNAL OF NEUROCHEMISTRY (2006)
Hippocampal synaptic loss in early Alzheimer's disease and mild cognitive impairment
Stephen W. Scheff et al.
NEUROBIOLOGY OF AGING (2006)
Cyclin-dependent kinase 5 in synaptic plasticity, learning and memory
Marco Angelo et al.
JOURNAL OF NEUROCHEMISTRY (2006)
The role of CDK5/P25 formation/inhibition in neurodegeneration
Antoni Camins et al.
DRUG NEWS & PERSPECTIVES (2006)
Role of MAPKs in development and differentiation: lessons from knockout mice
M. Aouadi et al.
BIOCHIMIE (2006)
MAPK-activated protein kinase 2 deficiency in microglia inhibits pro-inflammatory mediator release and resultant neurotoxicity - Relevance to neuroinflammation in a transgenic mouse model of Alzheimer disease
Ainsley A. Culbert et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
The cell cycle as a therapeutic target for Alzheimer's disease
Rachael L. Neve et al.
PHARMACOLOGY & THERAPEUTICS (2006)
The many paths to p38 mitogen-activated protein kinase activation in the immune system
Jonathan D. Ashwell
NATURE REVIEWS IMMUNOLOGY (2006)
Combined signaling through ERK, PI3K/AKT, and RAC1/p38 is required for Met-triggered cortical neuron migration
J Segarra et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Inhibition of calcineurin by FK506 protects against polyglutamine-huntingtin toxicity through an increase of huntingtin phosphorylation at S421
R Pardo et al.
JOURNAL OF NEUROSCIENCE (2006)
Hyperphosphorylation of microtubule-associated protein tau in senescence-accelerated mouse (SAM)
AM Canudas et al.
MECHANISMS OF AGEING AND DEVELOPMENT (2005)
E2F1 induces cell death, calpain activation, and MDMX degradation in a transcription independent manner implicating a novel role for E2F1 in neuronal loss in SIV encephalitis
GD Strachan et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2005)
The cell cycle in Alzheimer disease: A unique target for neuropharmacology
KM Webber et al.
MECHANISMS OF AGEING AND DEVELOPMENT (2005)
Inhibition of GSK3β is a common event in neuroprotection by different survival factors
PC Chin et al.
MOLECULAR BRAIN RESEARCH (2005)
Cdk5 phosphorylation of huntingtin reduces its cleavage by caspases: implications for mutant huntingtin toxicity
SQ Luo et al.
JOURNAL OF CELL BIOLOGY (2005)
Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo
W Noble et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Does lithium therapy protect against the onset of dementia?
N Dunn et al.
ALZHEIMER DISEASE & ASSOCIATED DISORDERS (2005)
Evidence that phosphorylation of the microtubule-associated protein Tau by SAPK4/p38δ at Thr50 promotes microtubule assembly
C Feijoo et al.
JOURNAL OF CELL SCIENCE (2005)
Activation and signaling of the p38 MAP kinase pathway
T Zarubin et al.
CELL RESEARCH (2005)
Secreted beta-amyloid precursor protein activates microglia via JNK and p38-MAPK
AM Bodles et al.
NEUROBIOLOGY OF AGING (2005)
Activating p38 MAPK - New tricks for an old kinase
PR Mittelstadt et al.
CELL CYCLE (2005)
Importance of MAPK pathways for microglial pro-inflammatory cytokine IL-1β production
SH Kim et al.
NEUROBIOLOGY OF AGING (2004)
Block of long-term potentiation by naturally secreted and synthetic amyloid β-peptide in hippocampal slices is mediated via activation of the kinases c-Jun N-terminal kinase, cyclin-dependent kinase 5, and p38 mitogen-activated protein kinase as well as metabotropic glutamate receptor type 5
QW Wang et al.
JOURNAL OF NEUROSCIENCE (2004)
Cyclin-dependent kinase-5 in neurodegeneration
SB Shelton et al.
JOURNAL OF NEUROCHEMISTRY (2004)
Adenosine and glutamate extracellular concentrations and mitogen-activated protein kinases in the striatum of Huntington transgenic mice.: Selective antagonism of adenosine A2A receptors reduces transmitter outflow
M Gianfriddo et al.
NEUROBIOLOGY OF DISEASE (2004)
Glycogen synthase kinase-3 inhibitors prevent caspase-dependent apoptosis induced by ethanol in cultured rat cortical neurons
T Takadera et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2004)
Cdk5 deregulation in the pathogenesis of Alzheimer's disease
JC Cruz et al.
TRENDS IN MOLECULAR MEDICINE (2004)
Lithium, a common drug for bipolar disorder treatment, regulates amyloid-β precursor protein processing
Y Su et al.
BIOCHEMISTRY (2004)
The serum- and glucocorticoid-induced kinase SGK inhibits mutant huntingtin-induced toxicity by phosphorylating serine 421 of huntingtin
H Rangone et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2004)
Evaluation and comparison of 3D-QSAR CoMSIA models for CDK1, CDK5, and GSK-3 inhibition by paullones
C Kunick et al.
JOURNAL OF MEDICINAL CHEMISTRY (2004)
Age-related myelin breakdown: a developmental model of cognitive decline and Alzheimer's disease
G Bartzokis
NEUROBIOLOGY OF AGING (2004)
Divide and die: Cell cycle events as triggers of nerve cell death
K Herrup et al.
JOURNAL OF NEUROSCIENCE (2004)
Cell cycle regulation of neuronal apoptosis in development and disease
EBE Becker et al.
PROGRESS IN NEUROBIOLOGY (2004)
Phosphorylation of p38 MAPK induced by oxidative stress is linked to activation of both caspase-8-and-9-mediated apoptotic pathways in dopaminergic neurons
WS Choi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Activation of the c-Jun transcription factor following neurodegeneration in vivo
J Schenkel
NEUROSCIENCE LETTERS (2004)
GSK-3β inhibition reverses axonal transport defects and behavioural phenotypes in Drosophila
A Mudher et al.
MOLECULAR PSYCHIATRY (2004)
p38 Kinase Is Activated in the Alzheimer's Disease Brain
Kenneth Hensley et al.
JOURNAL OF NEUROCHEMISTRY (2003)
Divergent roles of GSK3 and CDK5 in APP processing
J Ryder et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)
Structural insights and biological effects of glycogen synthase kinase 3-specific inhibitor AR-A014418
R Bhat et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
β-amyloid induces paired helical filament-like tau filaments in tissue culture
A Ferrari et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Chronic lithium chloride treatment has variable effects on motor behaviour and survival of mice transgenic for the Huntington's disease mutation
NI Wood et al.
BRAIN RESEARCH BULLETIN (2003)
Evidence for more widespread cerebral pathology in early HD - An MRI-based morphometric analysis
HD Rosas et al.
NEUROLOGY (2003)
GSK-3α regulates production of Alzheimer's disease amyloid-β peptides
CJ Phiel et al.
NATURE (2003)
Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effects
Y Mettey et al.
JOURNAL OF MEDICINAL CHEMISTRY (2003)
Role of cdk5 in the pathogenesis of Alzheimer's disease
LF Lau et al.
NEUROSIGNALS (2003)
Synaptic pathology in Alzheimer's disease: a review of ultrastructural studies
SW Scheff et al.
NEUROBIOLOGY OF AGING (2003)
Spatial learning deficit in transgenic mice that conditionally over-express GSK-3β in the brain but do not form tau filaments
F Hernández et al.
JOURNAL OF NEUROCHEMISTRY (2002)
β-amyloid-induced inflammation and cholinergic hypofunction in the rat brain in vivo:: Involvement of the p38MAPK pathway
MG Giovannini et al.
NEUROBIOLOGY OF DISEASE (2002)
Alzheimer's disease is a synaptic failure
DJ Selkoe
SCIENCE (2002)
Glycogen synthase kinase-3β inhibitors prevent cellular polyglutamine toxicity caused by the Huntington's disease mutation
J Carmichael et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Pyrazolo[3,4-b]quinoxalines.: A new class of cyclin-dependent kinases inhibitors
MA Ortega et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2002)
The IGF-1/Akt pathway is neuroprotective in Huntington's disease and involves huntingtin phosphorylation by Akt
S Humbert et al.
DEVELOPMENTAL CELL (2002)
Cyclooxygenase (COX)-2 and cell cycle activity in a transgenic mouse model of Alzheimer's Disease neuropathology
ZM Xiang et al.
NEUROBIOLOGY OF AGING (2002)
Cyclin-dependent kinase-5/p35 phosphorylates Presenilin 1 to regulate carboxy-terminal fragment stability
KF Lau et al.
MOLECULAR AND CELLULAR NEUROSCIENCE (2002)
Activation of MKK6, an upstream activator of p38, in Alzheimer's disease
XW Zhu et al.
JOURNAL OF NEUROCHEMISTRY (2001)
The p38 mitogen-activated protein kinase is involved in associative learning in rabbits
XC Zhen et al.
JOURNAL OF NEUROSCIENCE (2001)
Neuronal apoptosis at the G1/S cell cycle checkpoint
DX Liu et al.
CELL AND TISSUE RESEARCH (2001)
DNA replication precedes neuronal cell death in Alzheimer's disease
Y Yang et al.
JOURNAL OF NEUROSCIENCE (2001)
Redox-active iron mediates amyloid-β toxicity
CA Rottkamp et al.
FREE RADICAL BIOLOGY AND MEDICINE (2001)
Decreased nuclear β-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3β conditional transgenic mice
JJ Lucas et al.
EMBO JOURNAL (2001)
Localization of active forms of C-jun kinase (JNK) and p38 kinase in Alzheimer's disease brains at different stages of neurofibrillary degeneration
Jin-Jing Pei et al.
JOURNAL OF ALZHEIMERS DISEASE (2001)
The cell cycle Cdc25A tyrosine phosphatase is activated in degenerating postmitotic neurons in Alzheimer's disease
XL Ding et al.
AMERICAN JOURNAL OF PATHOLOGY (2000)
Beta-amyloid activated microglia induce cell cycling and cell death in cultured cortical neurons
Q Wu et al.
NEUROBIOLOGY OF AGING (2000)
Dual MAP kinase pathways mediate opposing forms of long-term plasticity at CA3-CA1 synapses
VY Bolshakov et al.
NATURE NEUROSCIENCE (2000)
c-Jun and the transcriptional control of neuronal apoptosis
J Ham et al.
BIOCHEMICAL PHARMACOLOGY (2000)
p38 MAP kinases: beyond the stress response
AR Nebreda et al.
TRENDS IN BIOCHEMICAL SCIENCES (2000)
Neurotoxicity induces cleavage of p35 to p25 by calpain
MS Lee et al.
NATURE (2000)
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