期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 22, 期 13, 页码 -出版社
MDPI
DOI: 10.3390/ijms22136954
关键词
diabetes; propolis; baccharin; PPAR gamma
资金
- Japan-Brazil Research Exchange Projects within the FY2013 Strategic International Research Cooperative Program (SICP) from the Japan Agency for Medical Research and Development (AMED)
- CNPq [490772/2013-7]
- Sao Paulo Research Foundation (FAPESP) [2017/04138-8]
- CAPES
Baccharin, a major component of Brazilian green propolis, promotes adipocyte differentiation by increasing lipid accumulation and glucose uptake through activation of PPAR gamma. In diabetic ob/ob mice, intraperitoneal administration of baccharin significantly improved blood glucose levels. These results suggest that baccharin has a hypoglycemic effect on glucose metabolic disorders, such as type 2 diabetes mellitus.
Propolis is a honeybee product with various biological activities, including antidiabetic effects. We previously reported that artepillin C, a prenylated cinnamic acid derivative isolated from Brazilian green propolis, acts as a peroxisome proliferator-activated receptor gamma (PPAR gamma) ligand and promotes adipocyte differentiation. In this study, we examined the effect of baccharin, another major component of Brazilian green propolis, on adipocyte differentiation. The treatment of mouse 3T3-L1 preadipocytes with baccharin resulted in increased lipid accumulation, cellular triglyceride levels, glycerol-3-phosphate dehydrogenase activity, and glucose uptake. The mRNA expression levels of PPAR gamma and its target genes were also increased by baccharin treatment. Furthermore, baccharin enhanced PPAR gamma-dependent luciferase activity, suggesting that baccharin promotes adipocyte differentiation via PPAR gamma activation. In diabetic ob/ob mice, intraperitoneal administration of 50 mg/kg baccharin significantly improved blood glucose levels. Our results suggest that baccharin has a hypoglycemic effect on glucose metabolic disorders, such as type 2 diabetes mellitus.
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